NP_115670.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
57,523 Da
NCBI Official Full Name
calcium/calmodulin-dependent protein kinase kinase 1 isoform a
NCBI Official Synonym Full Names
calcium/calmodulin-dependent protein kinase kinase 1, alpha
NCBI Official Synonym Symbols
NCBI Protein Information
calcium/calmodulin-dependent protein kinase kinase 1; caMKK 1; caM-KK 1; caM-KK alpha; CAMKK alpha protein; caM-kinase kinase 1; caM-kinase IV kinase; caM-kinase kinase alpha; calcium/calmodulin-dependent protein kinase kinase alpha
UniProt Protein Name
Calcium/calmodulin-dependent protein kinase kinase 1
UniProt Synonym Protein Names
CaM-kinase IV kinase; Calcium/calmodulin-dependent protein kinase kinase alpha; CaM-KK alpha; CaM-kinase kinase alpha; CaMKK alpha
UniProt Synonym Gene Names
CAMKKA; CaM-KK 1; CaM-kinase kinase 1; CaMKK 1; CaM-KK alpha; CaM-kinase kinase alpha; CaMKK alpha [Similar Products]
UniProt Entry Name
KKCC1_HUMAN
NCBI Summary for CAMKK1
The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade. Three transcript variants encoding two distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for CAMKK1
CAMKK1: a calcium/calmodulin-dependent S/T protein kinase of the CAMKK family. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death. 2 isoforms of the human protein are produced by alternative splicing. The autoinhibitory domain overlaps with the calmodulin binding region and may be involved in intrasteric autoinhibition. Binding of calmodulin may releave intrasteric autoinhibition. May be regulated through phosphorylation by CAMK1 and CAMK4. Appears to be autophosphorylated in a Ca2+/calmodulin-dependent manner. Phosphorylation of Ser-458 is blocked upon binding to Ca2+/calmodulin.
Protein type: Kinase, protein; EC 2.7.11.17; Protein kinase, Ser/Thr (non-receptor); Protein kinase, Other; Other group; CAMKK family; Meta subfamily
Chromosomal Location of Human Ortholog: 17p13.2
Cellular Component: nucleus; cytosol
Molecular Function: calmodulin binding; protein binding; calmodulin-dependent protein kinase activity; ATP binding
Biological Process: synaptic transmission; protein amino acid phosphorylation
Research Articles on CAMKK1
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Pathways associated with CAMKK1 elisa kit
Diseases associated with CAMKK1 elisa kit
Organs/Tissues associated with CAMKK1 elisa kit
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