NP_001035228.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
17,170 Da
NCBI Official Full Name
chemokine-like factor isoform e
NCBI Official Synonym Full Names
chemokine-like factor
NCBI Official Synonym Symbols
C32; CKLF1; CKLF2; CKLF3; CKLF4; UCK-1; HSPC224 [Similar Products]
NCBI Protein Information
chemokine-like factor; chemokine-like factor 1; chemokine-like factor 2; chemokine-like factor 3; chemokine-like factor 4; transmembrane proteolipid
UniProt Protein Name
Chemokine-like factor
UniProt Synonym Protein Names
C32
UniProt Synonym Gene Names
UniProt Entry Name
CKLF_HUMAN
NCBI Summary for CKLF
The product of this gene is a cytokine. Cytokines are small proteins that have an essential role in the immune and inflammatory responses. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 16. The protein encoded by this gene is a potent chemoattractant for neutrophils, monocytes and lymphocytes. It also can stimulate the proliferation of skeletal muscle cells. This protein may play important roles in inflammation and in the regeneration of skeletal muscle. Alternatively spliced transcript variants encoding different isoforms have been identified. Naturally occurring read-through transcription occurs between this locus and the neighboring locus CMTM1 (CKLF-like MARVEL transmembrane domain containing 1).[provided by RefSeq, Feb 2011]
UniProt Comments for CKLF
CKLF: May play an important role in inflammation and regeneration of skeletal muscle. Partly inhibited by interleukin 10. Belongs to the chemokine-like factor family. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Chemokine
Chromosomal Location of Human Ortholog: 16q21
Cellular Component: extracellular space; membrane; extracellular region; integral to membrane
Molecular Function: chemokine activity
Biological Process: neutrophil chemotaxis; cell proliferation; macrophage chemotaxis; lymphocyte chemotaxis; secretion by cell
Research Articles on CKLF
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Organs/Tissues associated with CKLF elisa kit
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