NP_001269347.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
145,751 Da
NCBI Official Full Name
cohesin subunit SA-2 isoform b
NCBI Official Synonym Full Names
stromal antigen 2
NCBI Protein Information
cohesin subunit SA-2; SCC3 homolog 2
UniProt Protein Name
Cohesin subunit SA-2
UniProt Synonym Protein Names
SCC3 homolog 2; Stromal antigen 2
UniProt Synonym Gene Names
UniProt Entry Name
STAG2_HUMAN
NCBI Summary for STAG2
The protein encoded by this gene is a subunit of the cohesin complex, which regulates the separation of sister chromatids during cell division. Targeted inactivation of this gene results in chromatid cohesion defects and aneuploidy, suggesting that genetic disruption of cohesin is a cause of aneuploidy in human cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
UniProt Comments for STAG2
STAG2: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Interacts directly with RAD21 in cohesin complex. Cohesin complexes are composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein (STAG1, STAG2 or STAG3). In cohesin complexes, STAG2 is mutually exclusive with STAG1 and STAG3. Belongs to the SCC3 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: Xq25
Cellular Component: nucleoplasm; intermediate filament cytoskeleton; membrane; nucleolus; plasma membrane; chromosome; chromatin; nucleus; cytosol; chromosome, pericentric region; actin cytoskeleton
Molecular Function: protein binding; chromatin binding
Biological Process: mitosis; meiotic cell cycle; cell division; stem cell maintenance; sister chromatid cohesion; negative regulation of DNA endoreduplication; mitotic cell cycle
Research Articles on STAG2
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Products associated with STAG2 elisa kit
Pathways associated with STAG2 elisa kit
Diseases associated with STAG2 elisa kit
Organs/Tissues associated with STAG2 elisa kit
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