NP_065084.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
73,364 Da
NCBI Official Full Name
collagen alpha-1(VIII) chain
NCBI Official Synonym Full Names
collagen, type VIII, alpha 1
NCBI Official Synonym Symbols
NCBI Protein Information
collagen alpha-1(VIII) chain; collagen alpha-1(VIII) chain; endothelial collagen; collagen VIII, alpha-1 polypeptide; cell proliferation-inducing protein 41; smooth muscle cell-expressed and macrophage conditioned medium-induced protein smag-64
UniProt Protein Name
Collagen alpha-1(VIII) chain
UniProt Synonym Protein Names
Endothelial collagen
UniProt Synonym Gene Names
UniProt Entry Name
CO8A1_HUMAN
NCBI Summary for COL8A1
This gene encodes one of the two alpha chains of type VIII collagen. The gene product is a short chain collagen and a major component of the basement membrane of the corneal endothelium. The type VIII collagen fibril can be either a homo- or a heterotrimer. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Dec 2011]
UniProt Comments for COL8A1
COL8A1: Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis.
Protein type: Secreted; Extracellular matrix; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 3q12.3
Cellular Component: extracellular matrix; intracellular membrane-bound organelle; endoplasmic reticulum lumen; collagen type VIII; extracellular region
Biological Process: collagen catabolic process; extracellular matrix disassembly; epithelial cell proliferation; extracellular matrix organization and biogenesis; camera-type eye morphogenesis; angiogenesis; cell adhesion
Research Articles on COL8A1
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Products associated with COL8A1 elisa kit
Pathways associated with COL8A1 elisa kit
Diseases associated with COL8A1 elisa kit
Organs/Tissues associated with COL8A1 elisa kit
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