AAY78556.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
62,542 Da
NCBI Official Full Name
ferroportin 1 variant I, partial
NCBI Official Synonym Full Names
solute carrier family 40 (iron-regulated transporter), member 1
NCBI Official Synonym Symbols
FPN1; HFE4; MTP1; IREG1; MST079; MSTP079; SLC11A3 [Similar Products]
NCBI Protein Information
solute carrier family 40 member 1; iron regulated gene 1; putative ferroportin 1 variant IIIA; putative ferroportin 1 variant IIIB; solute carrier family 11 (proton-coupled divalent metal ion transporters), member 3
UniProt Protein Name
Solute carrier family 40 member 1
UniProt Synonym Protein Names
Ferroportin-1; Iron-regulated transporter 1
UniProt Synonym Gene Names
UniProt Entry Name
S40A1_HUMAN
NCBI Summary for FPN
The protein encoded by this gene is a cell membrane protein that may be involved in iron export from duodenal epithelial cells. Defects in this gene are a cause of hemochromatosis type 4 (HFE4). [provided by RefSeq, Jul 2008]
UniProt Comments for FPN
SLC40A1: May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin). Defects in SLC40A1 are the cause of hemochromatosis type 4 (HFE4). HFE4 is an autosomal dominant iron-loading disorder characterized by early iron accumulation in reticuloendothelial cells and a marked increase in serum ferritin before elevation of the transferrin saturation. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.
Protein type: Transporter; Membrane protein, multi-pass; Membrane protein, integral; Transporter, SLC family
Chromosomal Location of Human Ortholog: 2q32
Cellular Component: multivesicular body; synaptic vesicle; basolateral plasma membrane; integral to plasma membrane; cytoplasm; integral to membrane; plasma membrane; intracellular
Molecular Function: iron ion transmembrane transporter activity; protein binding
Biological Process: anatomical structure morphogenesis; cellular iron ion homeostasis; positive regulation of transcription from RNA polymerase II promoter; transmembrane transport; lymphocyte homeostasis; negative regulation of apoptosis
Disease: Hemochromatosis, Type 4
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Pathways associated with FPN elisa kit
Diseases associated with FPN elisa kit
Organs/Tissues associated with FPN elisa kit
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