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GAD-AB elisa kit :: Sheep Glutamic Acid Decarboxylase Antibody ELISA Kit

Scan QR to view Datasheet Catalog #    MBS041148 GAD-AB elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Glutamic Acid Decarboxylase Antibody (GAD-AB), ELISA Kit

 Also Known As   

Sheep Glutamic Acid Decarboxylase Antibody ELISA Kit

 Product Gene Name   

GAD-AB elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    138275
 3D Structure    ModBase 3D Structure for Q05329
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 Species Reactivity    Sheep
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of GAD-AB elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for GAD-AB purchase    MBS041148 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Glutamic Acid Decarboxylase Antibody (GAD-AB) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing GAD-AB. The ELISA analytical biochemical technique of the MBS041148 kit is based on GAD-AB antibody-GAD-AB antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect GAD-AB antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, GAD-AB. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for GAD-AB. It may not necessarily be applicable to this product.
 NCBI GI #    4503875
 NCBI GeneID    2572
 NCBI Accession #    NP_000809.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000818.2 [Other Products]
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 UniProt Primary Accession #    Q05329 [Other Products]
 UniProt Secondary Accession #    Q9UD87 [Other Products]
 UniProt Related Accession #    Q05329 [Other Products]
 Molecular Weight    65,411 Da
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 NCBI Official Full Name    glutamate decarboxylase 2
 NCBI Official Synonym Full Names    glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
 NCBI Official Symbol    GAD2 [Similar Products]
 NCBI Official Synonym Symbols   
GAD65
[Similar Products]
 NCBI Protein Information    glutamate decarboxylase 2; GAD-65; 65 kDa glutamic acid decarboxylase; Glutamate decarboxylase-2 (pancreas); glutamate decarboxylase 65 kDa isoform
 UniProt Protein Name    Glutamate decarboxylase 2
 UniProt Synonym Protein Names   
65 kDa glutamic acid decarboxylase; GAD-65; Glutamate decarboxylase 65 kDa isoform
 UniProt Gene Name    GAD2 [Similar Products]
 UniProt Synonym Gene Names    GAD65; GAD-65 [Similar Products]
 UniProt Entry Name    DCE2_HUMAN
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 NCBI Summary for GAD-AB    This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2008]
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 UniProt Comments for GAD-AB    GAD2: Catalyzes the production of GABA. Homodimer. Belongs to the group II decarboxylase family.

Protein type: EC 4.1.1.15; Amino Acid Metabolism - alanine, aspartate and glutamate; Lyase; Carbohydrate Metabolism - butanoate; Other Amino Acids Metabolism - taurine and hypotaurine; Other Amino Acids Metabolism - beta-alanine

Chromosomal Location of Human Ortholog: 10p11.23

Cellular Component: Golgi membrane; presynaptic membrane; synaptic vesicle membrane; axon; perinuclear region of cytoplasm; plasma membrane; cytosol; cell junction

Molecular Function: protein binding; glutamate binding; glutamate decarboxylase activity; protein heterodimerization activity; pyridoxal phosphate binding

Biological Process: response to drug; synaptic transmission; glutamate decarboxylation to succinate; neurotransmitter secretion; neurotransmitter biosynthetic process
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 Research Articles on GAD-AB    1. GAD65 expression in 313 gastric cancer tissues was significantly higher than in 60 adjacent non-tumour tissues. Moreover, the expression level of GAD65 significantly correlated with the depth of tumour invasion and TNM stage.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with GAD-AB elisa kitPathways associated with GAD-AB elisa kit
 Reference Product  PubMed Publications
 GAD1 elisa kit  >48 publications with GAD-AB and GAD1
 GLUL elisa kit  >1 publications with GAD-AB and GLUL
 INS elisa kit  >1 publications with GAD-AB and INS
 SLC32A1 elisa kit  >1 publications with GAD-AB and SLC32A1
 ABAT elisa kit  >1 publications with GAD-AB and ABAT
 Products by Pathway  Pathway Diagram
 Alanine And Aspartate Metabolism Pathway antibodies  Alanine And Aspartate Metabolism Pathway Diagram
 Alanine, Aspartate And Glutamate Metabolism Pathway antibodies  Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
 Alanine, Aspartate And Glutamate Metabolism Pathway antibodies  Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
 Biogenic Amine Synthesis Pathway antibodies  Biogenic Amine Synthesis Pathway Diagram
 Butanoate Metabolism Pathway antibodies  Butanoate Metabolism Pathway Diagram
 Butanoate Metabolism Pathway antibodies  Butanoate Metabolism Pathway Diagram
 GABA (gamma-Aminobutyrate) Shunt Pathway antibodies  GABA (gamma-Aminobutyrate) Shunt Pathway Diagram
 GABA (gamma-Aminobutyrate) Shunt Pathway antibodies  GABA (gamma-Aminobutyrate) Shunt Pathway Diagram
 GABA Synthesis Pathway antibodies  GABA Synthesis Pathway Diagram
 GABA Synthesis, Release, Reuptake And Degradation Pathway antibodies  GABA Synthesis, Release, Reuptake And Degradation Pathway Diagram
Diseases associated with GAD-AB elisa kitOrgans/Tissues associated with GAD-AB elisa kit
 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >18 publications with GAD-AB and Mental Disorders
 Nervous System Diseases Antibodies  >12 publications with GAD-AB and Nervous System Diseases
 Brain Diseases Antibodies  >10 publications with GAD-AB and Brain Diseases
 Schizophrenia Antibodies  >9 publications with GAD-AB and Schizophrenia
 Epilepsy Antibodies  >6 publications with GAD-AB and Epilepsy
 Seizures Antibodies  >6 publications with GAD-AB and Seizures
 Inflammation Antibodies  >4 publications with GAD-AB and Inflammation
 Depressive Disorder Antibodies  >3 publications with GAD-AB and Depressive Disorder
 Movement Disorders Antibodies  >2 publications with GAD-AB and Movement Disorders
 Substance Withdrawal Syndrome Antibodies  >2 publications with GAD-AB and Substance Withdrawal Syndrome
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >34 publications with GAD-AB and Brain
 Pancreas Antibodies  >3 publications with GAD-AB and Pancreas
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