AAC83553.1
[Other Products]
UniProt Secondary Accession #
Molecular Weight
130,628 Da
NCBI Official Full Name
inducible nitric oxide synthase
UniProt Protein Name
Nitric oxide synthase, inducible
UniProt Synonym Protein Names
Inducible NO synthase; Inducible NOS; iNOS; NOS type II; Peptidyl-cysteine S-nitrosylase NOS2
UniProt Synonym Gene Names
UniProt Entry Name
NOS2_RAT
UniProt Comments for iNOS
iNOS: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2. Homodimer. Binds SLC9A3R1. By endotoxins and cytokines. Induced by IFNG/IFN-gamma acting synergistically with bacterial lipopolysaccharides (LPS), TNF or IL1B/interleukin-1 beta. Expressed in the liver, retina, bone cells and airway epithelial cells of the lung. Not expressed in the platelets. Regulated by calcium/calmodulin. Aspirin inhibits expression and function of this enzyme and effects may be exerted at the level of translational/post-translational modification and directly on the catalytic activity. Belongs to the NOS family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Amino Acid Metabolism - arginine and proline; Oxidoreductase; EC 1.14.13.39
Cellular Component: cortical cytoskeleton; extracellular space; perinuclear region of cytoplasm; cytoplasm; peroxisome; vesicle membrane; intracellular; nucleus; cytosol
Molecular Function: protein homodimerization activity; FAD binding; nitric-oxide synthase activity; beta-catenin binding; cAMP-dependent protein kinase regulator activity; Hsp90 protein binding; actin binding; protein kinase binding; calmodulin binding; amino acid binding; NADPH-hemoprotein reductase activity; FMN binding; cadherin binding; iron ion binding; heme binding; nitric-oxide synthase binding; NADP binding; receptor binding
Biological Process: retinoic acid receptor signaling pathway; wound healing; cGMP-mediated signaling; positive regulation of apoptosis; response to hormone stimulus; response to lipopolysaccharide; positive regulation of killing of cells of another organism; signal transduction; positive regulation of vasodilation; defense response to Gram-negative bacterium; regulation of heart contraction; response to estradiol stimulus; regulation of blood pressure; negative regulation of blood pressure; inflammatory response; nitric oxide biosynthetic process; glycoside metabolic process; aging; superoxide metabolic process; positive regulation of guanylate cyclase activity; ovulation from ovarian follicle; regulation of cell proliferation; response to mechanical stimulus; endothelial cell proliferation; defense response to bacterium; peptidyl-cysteine S-nitrosylation; response to hypoxia; arginine catabolic process; G-protein signaling, coupled to cGMP nucleotide second messenger; blood vessel remodeling; response to activity; regulation of protein kinase activity; negative regulation of protein catabolic process; regulation of insulin secretion; nitric oxide mediated signal transduction
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