AAH25843.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
138,908 Da
NCBI Official Full Name
L1CAM protein, partial
NCBI Official Synonym Full Names
L1 cell adhesion molecule
NCBI Official Synonym Symbols
S10; HSAS; MASA; MIC5; SPG1; CAML1; CD171; HSAS1; N-CAML1; NCAM-L1; N-CAM-L1 [Similar Products]
NCBI Protein Information
neural cell adhesion molecule L1; antigen identified by monoclonal antibody R1
UniProt Protein Name
Neural cell adhesion molecule L1
UniProt Synonym Protein Names
CD_antigen: CD171
UniProt Synonym Gene Names
UniProt Entry Name
L1CAM_HUMAN
NCBI Summary for L1CAM
The protein encoded by this gene is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause X-linked neurological syndromes known as CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of this gene results in multiple transcript variants, some of which include an alternate exon that is considered to be specific to neurons. [provided by RefSeq, May 2013]
UniProt Comments for L1CAM
NCAM-L1: cell adhesion molecule with an important role in the development of the nervous system. Involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. Binds to axonin on neurons. Two splice-variant isoforms have been described.
Protein type: Membrane protein, integral; Cell adhesion
Chromosomal Location of Human Ortholog: Xq28
Cellular Component: presynaptic membrane; cell surface; focal adhesion; plasma membrane; integral to membrane; terminal button; external side of plasma membrane
Molecular Function: integrin binding; identical protein binding; protein self-association; sialic acid binding
Biological Process: axon guidance; nervous system development; positive regulation of calcium-mediated signaling; chemotaxis; heterophilic cell adhesion; leukocyte adhesion; cell surface receptor linked signal transduction; homotypic cell-cell adhesion; cell-cell adhesion mediated by integrin; positive regulation of cell-cell adhesion; blood coagulation; homophilic cell adhesion; cell adhesion; leukocyte migration
Disease: Hydrocephalus Due To Congenital Stenosis Of Aqueduct Of Sylvius; Corpus Callosum, Partial Agenesis Of, X-linked; Masa Syndrome
Research Articles on L1CAM
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Products associated with L1CAM elisa kit
Pathways associated with L1CAM elisa kit
Diseases associated with L1CAM elisa kit
Organs/Tissues associated with L1CAM elisa kit
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