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LEPR elisa kit :: Sheep Leptin receptor (LEPR) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS7216348 LEPR elisa kit
Unit / Price
48-Strip-Wells  /  $455 +1 FREE 8GB USB
96-Strip-Wells  /  $660 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,925 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,490 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Leptin receptor (LEPR), ELISA Kit

 Also Known As   

Sheep Leptin receptor (LEPR) ELISA Kit

 Product Gene Name   

LEPR elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    gene 614963
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 Species Reactivity    Sheep
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 Samples    Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of LEPR elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for LEPR purchase    MBS7216348 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Leptin receptor (LEPR) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing LEPR. The ELISA analytical biochemical technique of the MBS7216348 kit is based on LEPR antibody-LEPR antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect LEPR antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, LEPR. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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 Product Categories/Family for LEPR elisa kit    Signal Transduction
NCBI/Uniprot data below describe general gene information for LEPR. It may not necessarily be applicable to this product.
 NCBI GI #    116242617
 NCBI GeneID    3953
 NCBI Accession #    P48357.2 [Other Products]
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 UniProt Secondary Accession #    Q13592; Q13593; Q13594; Q92919; Q92920; Q92921 [Other Products]
 UniProt Related Accession #    P48357 [Other Products]
 Molecular Weight    96,042 Da
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 NCBI Official Full Name    Leptin receptor
 NCBI Official Synonym Full Names    leptin receptor
 NCBI Official Symbol    LEPR [Similar Products]
 NCBI Official Synonym Symbols   
OBR; OB-R; CD295; LEP-R; LEPRD
[Similar Products]
 NCBI Protein Information    leptin receptor; huB219; OB receptor
 UniProt Protein Name    Leptin receptor
 UniProt Synonym Protein Names   
HuB219; OB receptor; OB-R; CD_antigen: CD295
 Protein Family    Leptin receptor
 UniProt Gene Name    LEPR [Similar Products]
 UniProt Synonym Gene Names    DB; OBR; LEP-R; OB-R [Similar Products]
 UniProt Entry Name    LEPR_HUMAN
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 NCBI Summary for LEPR    The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).[provided by RefSeq, Nov 2010]
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 UniProt Comments for LEPR    LEPR: the receptor for leptin (obesity factor). A single-transmembrane-domain receptor of the cytokine receptor family. On ligand binding, mediates signaling through JAK2/STAT3. Involved in the regulation of fat metabolism and, in a hematopoietic pathway, required for normal lymphopoiesis. May play a role in reproduction. Five alternatively spliced transcript variants have been reported.

Protein type: Receptor, cytokine; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p31

Cellular Component: plasma membrane; extracellular region; integral to membrane; receptor complex

Molecular Function: identical protein binding; hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding; transmembrane receptor activity

Biological Process: cholesterol metabolic process; cell surface receptor linked signal transduction; multicellular organismal development; negative regulation of gluconeogenesis; negative regulation of hydrolase activity; cytokine and chemokine mediated signaling pathway; energy reserve metabolic process

Disease: Leptin Receptor Deficiency
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 Research Articles on LEPR    1. These results show that leptin and OBR are constitutively expressed and widely distributed in dental and periodontal tissues of primates.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with LEPR elisa kitPathways associated with LEPR elisa kit
 Reference Product  PubMed Publications
 LEP elisa kit  >173 publications with LEPR and LEP
 STAT3 elisa kit  >51 publications with LEPR and STAT3
 JAK2 elisa kit  >13 publications with LEPR and JAK2
 INS elisa kit  >9 publications with LEPR and INS
 SOCS3 elisa kit  >9 publications with LEPR and SOCS3
 IRS1 elisa kit  >8 publications with LEPR and IRS1
 APOD elisa kit  >2 publications with LEPR and APOD
 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Leptin Signaling Pathway antibodies  Leptin Signaling Pathway Diagram
Diseases associated with LEPR elisa kitOrgans/Tissues associated with LEPR elisa kit
 Disease Name  Pubmed Publications
 Peripheral Nervous System Diseases Antibodies  >402 publications with LEPR and Peripheral Nervous System Diseases
 Obesity Antibodies  >376 publications with LEPR and Obesity
 Drug-Related Side Effects and Adverse Reactions Antibodies  >349 publications with LEPR and Drug-Related Side Effects and Adverse Reactions
 Overweight Antibodies  >241 publications with LEPR and Overweight
 Diabetes Mellitus Antibodies  >211 publications with LEPR and Diabetes Mellitus
 Inflammation Antibodies  >198 publications with LEPR and Inflammation
 Diabetes Mellitus, Type 2 Antibodies  >120 publications with LEPR and Diabetes Mellitus, Type 2
 Insulin Resistance Antibodies  >110 publications with LEPR and Insulin Resistance
 Necrosis Antibodies  >110 publications with LEPR and Necrosis
 Immunologic Deficiency Syndromes Antibodies  >94 publications with LEPR and Immunologic Deficiency Syndromes
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >1395 publications with LEPR and Skin
 Blood Antibodies  >1221 publications with LEPR and Blood
 Nerve Antibodies  >682 publications with LEPR and Nerve
 Liver Antibodies  >237 publications with LEPR and Liver
 Muscle Antibodies  >233 publications with LEPR and Muscle
 Eye Antibodies  >182 publications with LEPR and Eye
 Bone Antibodies  >157 publications with LEPR and Bone
 Connective Tissue Antibodies  >129 publications with LEPR and Connective Tissue
 Brain Antibodies  >128 publications with LEPR and Brain
 Vascular Antibodies  >124 publications with LEPR and Vascular
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