AAB23549.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
46,944 Da
NCBI Official Full Name
lysyl oxidase
NCBI Official Synonym Full Names
lysyl oxidase
NCBI Protein Information
protein-lysine 6-oxidase
UniProt Protein Name
Protein-lysine 6-oxidase
UniProt Synonym Protein Names
Lysyl oxidase
UniProt Entry Name
LYOX_HUMAN
NCBI Summary for LOX
The protein encoded by this gene is an extracellular copper enzyme that initiates the crosslinking of collagens and elastin. The enzyme catalyzes oxidative deamination of the epsilon-amino group in certain lysine and hydroxylysine residues of collagens and lysine residues of elastin. In addition to crosslinking extracellular matrix proteins, the encoded protein may have a role in tumor suppression. Defects in this gene are a cause of autosomal recessive cutis laxa type I (CL type I). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]
UniProt Comments for LOX
LOX: Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct role in tumor suppression. Belongs to the lysyl oxidase family.
Protein type: EC 1.4.3.13; Secreted, signal peptide; Secreted; Oxidoreductase
Chromosomal Location of Human Ortholog: 5q23.2
Cellular Component: extracellular space; proteinaceous extracellular matrix; collagen; extracellular region; nucleus
Molecular Function: protein binding; copper ion binding; protein-lysine 6-oxidase activity
Biological Process: response to drug; elastic fiber assembly; blood vessel development; extracellular matrix organization and biogenesis; collagen fibril organization; wound healing; response to steroid hormone stimulus; protein modification process; lung development
Disease: Cutis Laxa, Autosomal Recessive, Type Ia
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Products associated with LOX elisa kit
Pathways associated with LOX elisa kit
Diseases associated with LOX elisa kit
Organs/Tissues associated with LOX elisa kit
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