AAB72040.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
55,948 Da
NCBI Official Full Name
metabotropic glutamate receptor 8
NCBI Official Synonym Full Names
glutamate receptor, metabotropic 8
NCBI Protein Information
metabotropic glutamate receptor 8
UniProt Protein Name
Metabotropic glutamate receptor 8
UniProt Synonym Gene Names
UniProt Entry Name
GRM8_HUMAN
NCBI Summary for GRM8
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for GRM8
mGluR8: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. Belongs to the G-protein coupled receptor 3 family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; GPCR, family 3; Receptor, GPCR; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 7q31.3-q32.1
Cellular Component: presynaptic membrane; integral to plasma membrane; plasma membrane
Molecular Function: G-protein coupled receptor activity; group III metabotropic glutamate receptor activity; glutamate receptor activity
Biological Process: negative regulation of cAMP biosynthetic process; regulation of synaptic transmission, glutamatergic; visual perception; sensory perception of smell; metabotropic glutamate receptor, adenylate cyclase inhibiting pathway
Research Articles on GRM8
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Pathways associated with GRM8 elisa kit
Diseases associated with GRM8 elisa kit
Organs/Tissues associated with GRM8 elisa kit
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