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PSAP elisa kit :: Sheep Prosaposin ELISA Kit

Scan QR to view Datasheet Catalog #    MBS020958 PSAP elisa kit
Unit / Price
48-Strip-Wells  /  $470 +1 FREE 8GB USB
96-Strip-Wells  /  $680 +1 FREE 8GB USB
5x96-Strip-Wells  /  $3,100 +3 FREE 8GB USB
10x96-Strip-Wells  /  $6,095 +7 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Prosaposin (PSAP), ELISA Kit

 Also Known As   

Sheep Prosaposin ELISA Kit

 Product Gene Name   

PSAP elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 10; NC_000010.10 (73576055..73611082, complement). Location: 10q21-q22
 OMIM    176801
 3D Structure    ModBase 3D Structure for P07602
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 Species Reactivity    Sheep
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of PSAP elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for PSAP purchase    MBS020958 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Prosaposin (PSAP) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing PSAP. The ELISA analytical biochemical technique of the MBS020958 kit is based on PSAP antibody-PSAP antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect PSAP antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, PSAP. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for PSAP. It may not necessarily be applicable to this product.
 NCBI GI #    48145609
 NCBI GeneID    5660
 NCBI Accession #    CAG33027.1 [Other Products]
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 UniProt Primary Accession #    P07602 [Other Products]
 UniProt Secondary Accession #    P07292; P15793; P78538; P78541; P78546; P78547; P78558; Q53Y86; Q6IBQ6; Q92739; Q92740 [Other Products]
 UniProt Related Accession #    P07602 [Other Products]
 Molecular Weight    58,113 Da
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 NCBI Official Full Name    PSAP
 NCBI Official Synonym Full Names    prosaposin
 NCBI Official Symbol    PSAP [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    proactivator polypeptide; sphingolipid activator protein-1
 UniProt Protein Name    Proactivator polypeptide
 UniProt Synonym Protein Names   
Protein ASaposin-B-ValSaposin-B; Alternative name(s):; Cerebroside sulfate activator; CSAct; Dispersin; Sphingolipid activator protein 1; SAP-1; Sulfatide/GM1 activatorSaposin-C; Alternative name(s):; A1 activator; Co-beta-glucosidase; Glucosylceramidase activator; Sphingolipid activator protein 2; SAP-2Saposin-D; Alternative name(s):; Component C; Protein C
 Protein Family    Prosaposin
 UniProt Gene Name    PSAP [Similar Products]
 UniProt Synonym Gene Names    GLBA; SAP1; CSAct; SAP-1; SAP-2 [Similar Products]
 UniProt Entry Name    SAP_HUMAN
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 NCBI Summary for PSAP    This gene encodes a highly conserved glycoprotein which is a precursor for 4 cleavage products: saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease, Tay-Sachs disease, and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PSAP    PSAP: The lysosomal degradation of sphingolipids takes place by the sequential action of specific hydrolases. Some of these enzymes require specific low-molecular mass, non-enzymic proteins: the sphingolipids activator proteins (coproteins). Defects in PSAP are the cause of combined saposin deficiency (CSAPD); also known as prosaposin deficiency. CSAPD is due to absence of all saposins, leading to a fatal storage disorder with hepatosplenomegaly and severe neurological involvement. Defects in PSAP saposin-B region are the cause of leukodystrophy metachromatic due to saposin-B deficiency (MLD- SAPB). MLD-SAPB is an atypical form of metachromatic leukodystrophy. It is characterized by tissue accumulation of cerebroside-3-sulfate, demyelination, periventricular white matter abnormalities, peripheral neuropathy. Additional neurological features include dysarthria, ataxic gait, psychomotr regression, seizures, cognitive decline and spastic quadriparesis. Defects in PSAP saposin-C region are the cause of atypical Gaucher disease (AGD). Affected individuals have marked glucosylceramide accumulation in the spleen without having a deficiency of glucosylceramide-beta glucosidase characteristic of classic Gaucher disease, a lysosomal storage disorder. Defects in PSAP saposin-A region are the cause of atypical Krabbe disease (AKRD). AKRD is a disorder of galactosylceramide metabolism. AKRD features include progressive encephalopathy and abnormal myelination in the cerebral white matter resembling Krabbe disease. Defects in PSAP saposin-D region are found in a variant of Tay-Sachs disease (GM2-gangliosidosis). 3 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 10q21-q22

Cellular Component: nucleoplasm; Golgi apparatus; lysosomal lumen; extracellular space; mitochondrion; intracellular membrane-bound organelle; lysosomal membrane; extracellular region; nucleolus; integral to membrane

Molecular Function: protein binding; enzyme activator activity; lipid binding

Biological Process: positive regulation of catalytic activity; platelet activation; platelet degranulation; sphingolipid metabolic process; regulation of lipid metabolic process; regulation of MAPKKK cascade; glycosphingolipid metabolic process; blood coagulation; lipid transport

Disease: Gaucher Disease, Atypical, Due To Saposin C Deficiency; Metachromatic Leukodystrophy Due To Saposin B Deficiency; Combined Saposin Deficiency; Krabbe Disease, Atypical, Due To Saposin A Deficiency
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 Research Articles on PSAP    1. These findings suggested that prosaposin might enhance estrogen receptor alpha-mediated signaling axis and play a role in breast cancer development and progression.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with PSAP elisa kitDiseases associated with PSAP elisa kit
 Products by Pathway  Pathway Diagram
 Glycosphingolipid Metabolism Pathway antibodies  Glycosphingolipid Metabolism Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Platelet Activation, Signaling And Aggregation Pathway antibodies  Platelet Activation, Signaling And Aggregation Pathway Diagram
 Platelet Degranulation Pathway antibodies  Platelet Degranulation Pathway Diagram
 Response To Elevated Platelet Cytosolic Ca2+ Pathway antibodies  Response To Elevated Platelet Cytosolic Ca2+ Pathway Diagram
 Sphingolipid Metabolism Pathway antibodies  Sphingolipid Metabolism Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >123 publications with PSAP and Nervous System Diseases
 Brain Diseases Antibodies  >103 publications with PSAP and Brain Diseases
 Neoplasms Antibodies  >90 publications with PSAP and Neoplasms
 Metachromatic Leukodystrophy due to Saposin B Deficiency Antibodies  >26 publications with PSAP and Metachromatic Leukodystrophy due to Saposin B Deficiency
 Skin Diseases Antibodies  >23 publications with PSAP and Skin Diseases
 Liver Diseases Antibodies  >19 publications with PSAP and Liver Diseases
 Cardiovascular Diseases Antibodies  >17 publications with PSAP and Cardiovascular Diseases
 Hyperplasia Antibodies  >13 publications with PSAP and Hyperplasia
 Breast Neoplasms Antibodies  >12 publications with PSAP and Breast Neoplasms
 Nerve Degeneration Antibodies  >10 publications with PSAP and Nerve Degeneration
Organs/Tissues associated with PSAP elisa kit
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >96 publications with PSAP and Brain
 Prostate Antibodies  >79 publications with PSAP and Prostate
 Blood Antibodies  >63 publications with PSAP and Blood
 Liver Antibodies  >48 publications with PSAP and Liver
 Nerve Antibodies  >44 publications with PSAP and Nerve
 Testis Antibodies  >42 publications with PSAP and Testis
 Kidney Antibodies  >37 publications with PSAP and Kidney
 Skin Antibodies  >32 publications with PSAP and Skin
 Spleen Antibodies  >25 publications with PSAP and Spleen
 Muscle Antibodies  >18 publications with PSAP and Muscle
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