Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow ELISA Kit rightarrow RSPO1 rightarrow Sheep RSPO1  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • (Rhesus macaque) Interleukin-8 (IL8) Recombinant Protein
 • Fibroblast Growth Factor 13 (FGF13) ELISA Kit
 • INDO-IDO (IDO1) Antibody
 • Kappa LightChain-IGKC Antibody
 • Blebbistatin Inhibitor
 • R-Spondin 1 (RSPO1) ELISA Kit
 • Ribose-phosphate pyrophosphokinase 2 (Prps2) Recombinant Protein
 • PolioVirus 1 PCR Kit
 • Glypican 3 (GPC3) ELISA Kit
 • RHOA cDNA Clone
 • CA14 Antibody
 • Neutrophil Gelatinase Associated Lipocalin (NGAL) ELISA Kit
 • Carbonic Anhydrase IX (CA9) ELISA Kit
 • 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial (... Recombinant Protein
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

RSPO1 elisa kit :: Sheep R-Spondin 1 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS079178 RSPO1 elisa kit
Unit / Price
48-Strip-Wells  /  $470 +1 FREE 8GB USB
96-Strip-Wells  /  $680 +1 FREE 8GB USB
5x96-Strip-Wells  /  $3,100 +3 FREE 8GB USB
10x96-Strip-Wells  /  $6,095 +7 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

R-Spondin 1 (RSPO1), ELISA Kit

 Also Known As   

Sheep R-Spondin 1 ELISA Kit

 Product Gene Name   

RSPO1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 Request for Current Manual Insert    Request Current Manual
 OMIM    609595
 3D Structure    ModBase 3D Structure for Q2MKA7
Section Bar
 Species Reactivity    Sheep
Section Bar
Section Bar
 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of RSPO1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for RSPO1 purchase    MBS079178 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the R-Spondin 1 (RSPO1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing RSPO1. The ELISA analytical biochemical technique of the MBS079178 kit is based on RSPO1 antibody-RSPO1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect RSPO1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, RSPO1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for RSPO1. It may not necessarily be applicable to this product.
 NCBI GI #    84490388
 NCBI GeneID    284654
 NCBI Accession #    NP_001033722.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001038633.3 [Other Products]
Section Bar
 UniProt Primary Accession #    Q2MKA7 [Other Products]
 UniProt Secondary Accession #    Q0H8S6; Q14C72; Q5T0F2; Q8N7L5; A2A420 [Other Products]
 UniProt Related Accession #    Q2MKA7 [Other Products]
 Molecular Weight    28,959 Da
Table BarTOPTable Bar
 NCBI Official Full Name    R-spondin-1 isoform 1
 NCBI Official Synonym Full Names    R-spondin 1
 NCBI Official Symbol    RSPO1 [Similar Products]
 NCBI Official Synonym Symbols   
RSPO; CRISTIN3
[Similar Products]
 NCBI Protein Information    R-spondin-1; R-spondin homolog; roof plate-specific spondin-1
 UniProt Protein Name    R-spondin-1
 UniProt Synonym Protein Names   
Roof plate-specific spondin-1
 Protein Family    R-spondin
 UniProt Gene Name    RSPO1 [Similar Products]
 UniProt Synonym Gene Names    hRspo1 [Similar Products]
 UniProt Entry Name    RSPO1_HUMAN
Section Bar
 NCBI Summary for RSPO1    This gene encodes a secreted activator protein with two cysteine-rich, furin-like domains and one thrombospondin type 1 domain. The encoded protein is a ligand for leucine-rich repeat-containing G-protein coupled receptors (LGR proteins) and positively regulates the Wnt signaling pathway. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Section Bar
 UniProt Comments for RSPO1    R-spondin-1: Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination. Defects in RSPO1 are the cause of palmoplantar keratoderma with squamous cell carcinoma of skin and sex reversal (PKKSCC). This recessive syndrome is characterized by XX (female to male) SRY-independent sex reversal, palmoplantar hyperkeratosis and predisposition to squamous cell carcinoma of the skin. Belongs to the R-spondin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Cell development/differentiation; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1p34.3

Cellular Component: extracellular space; extracellular region; nucleus

Molecular Function: heparin binding; protein binding; G-protein-coupled receptor binding; receptor binding

Biological Process: regulation of gene expression; regulation of receptor internalization; Wnt receptor signaling pathway through beta-catenin; positive regulation of protein amino acid phosphorylation; male meiosis; positive regulation of Wnt receptor signaling pathway

Disease: Palmoplantar Hyperkeratosis With Squamous Cell Carcinoma Of Skin And 46,xx Sex Reversal
Table BarTOPTable Bar
 Research Articles on RSPO1    1. Loss of RSPO1 expression is associated with invasive ductal carcinoma of the breast.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with RSPO1 elisa kitPathways associated with RSPO1 elisa kit
 Reference Product  PubMed Publications
 SRY elisa kit  >33 publications with RSPO1 and SRY
 SOX9 elisa kit  >29 publications with RSPO1 and SOX9
 FOXL2 elisa kit  >19 publications with RSPO1 and FOXL2
 LRP6 elisa kit  >11 publications with RSPO1 and LRP6
 DKK1 elisa kit  >9 publications with RSPO1 and DKK1
 ZNRF3 elisa kit  >7 publications with RSPO1 and ZNRF3
 FURIN elisa kit  >7 publications with RSPO1 and FURIN
 STRA8 elisa kit  >2 publications with RSPO1 and STRA8
 MYF5 elisa kit  >1 publications with RSPO1 and MYF5
 Products by Pathway  Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 RNF Mutants Show Enhanced WNT Signaling And Proliferation Pathway antibodies  RNF Mutants Show Enhanced WNT Signaling And Proliferation Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By WNT In Cancer Pathway antibodies  Signaling By WNT In Cancer Pathway Diagram
 Signaling By Wnt Pathway antibodies  Signaling By Wnt Pathway Diagram
 TCF Dependent Signaling In Response To WNT Pathway antibodies  TCF Dependent Signaling In Response To WNT Pathway Diagram
 Wnt Signaling Network Pathway antibodies  Wnt Signaling Network Pathway Diagram
 XAV939 Inhibits Tankyrase, Stabilizing AXIN Pathway antibodies  XAV939 Inhibits Tankyrase, Stabilizing AXIN Pathway Diagram
 Misspliced LRP5 Mutants Have Enhanced Beta-catenin-dependent Signaling Pathway antibodies  Misspliced LRP5 Mutants Have Enhanced Beta-catenin-dependent Signaling Pathway Diagram
 Regulation Of FZD By Ubiquitination Pathway antibodies  Regulation Of FZD By Ubiquitination Pathway Diagram
Diseases associated with RSPO1 elisa kitOrgans/Tissues associated with RSPO1 elisa kit
 Disease Name  Pubmed Publications
 Urogenital Abnormalities Antibodies  >23 publications with RSPO1 and Urogenital Abnormalities
 Neoplasms Antibodies  >12 publications with RSPO1 and Neoplasms
 Skin Diseases Antibodies  >5 publications with RSPO1 and Skin Diseases
 Embryo Loss Antibodies  >3 publications with RSPO1 and Embryo Loss
 Musculoskeletal Abnormalities Antibodies  >2 publications with RSPO1 and Musculoskeletal Abnormalities
 Adenocarcinoma Antibodies  >2 publications with RSPO1 and Adenocarcinoma
 Weight Loss Antibodies  >2 publications with RSPO1 and Weight Loss
 Hyperplasia Antibodies  >2 publications with RSPO1 and Hyperplasia
 Neoplasms, Experimental Antibodies  >2 publications with RSPO1 and Neoplasms, Experimental
 Necrosis Antibodies  >2 publications with RSPO1 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >32 publications with RSPO1 and Testis
 Ovary Antibodies  >31 publications with RSPO1 and Ovary
 Intestine Antibodies  >14 publications with RSPO1 and Intestine
 Pancreas Antibodies  >4 publications with RSPO1 and Pancreas
 Muscle Antibodies  >2 publications with RSPO1 and Muscle
 Connective Tissue Antibodies  >2 publications with RSPO1 and Connective Tissue
 Brain Antibodies  >2 publications with RSPO1 and Brain
 Eye Antibodies  >2 publications with RSPO1 and Eye
 Heart Antibodies  >1 publications with RSPO1 and Heart
 Prostate Antibodies  >1 publications with RSPO1 and Prostate
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions