CAH73767.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
Molecular Weight
21,452 Da
UniProt Protein Name
Regulator of G-protein signaling 4
UniProt Synonym Gene Names
UniProt Entry Name
RGS4_HUMAN
UniProt Comments for RGS4
RGS4: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein. Expressed in brain and heart. Expressed in brain at protein level. Expressed in prefontal and visual cortex. Isoform 4 and isoform 5 are expressed ubiquitously. Isoform 1, isoform 2 and isoform 3 are not expressed in the cerebellum. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: GAPs; GAPs, RGS
Chromosomal Location of Human Ortholog: 1q23.3
Cellular Component: protein complex; cytoplasm; plasma membrane; cytosol
Molecular Function: calmodulin binding; G-protein alpha-subunit binding; GTPase activator activity
Biological Process: regulation of G-protein coupled receptor protein signaling pathway; positive regulation of GTPase activity; inactivation of MAPK activity
Disease: Schizophrenia 9
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Products associated with RGS4 elisa kit
Diseases associated with RGS4 elisa kit
Organs/Tissues associated with RGS4 elisa kit
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