AAA59188.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
135,363 Da
NCBI Official Full Name
retinol-binding protein
NCBI Official Synonym Full Names
retinol binding protein 3, interstitial
NCBI Official Synonym Symbols
IRBP; RBPI; RP66; D10S64; D10S65; D10S66 [Similar Products]
NCBI Protein Information
retinol-binding protein 3; interphotoreceptor retinoid-binding protein
UniProt Protein Name
Retinol-binding protein 3
UniProt Synonym Protein Names
Interphotoreceptor retinoid-binding protein; IRBP; Interstitial retinol-binding protein
UniProt Synonym Gene Names
UniProt Entry Name
RET3_HUMAN
NCBI Summary for RBP
Interphotoreceptor retinol-binding protein is a large glycoprotein known to bind retinoids and found primarily in the interphotoreceptor matrix of the retina between the retinal pigment epithelium and the photoreceptor cells. It is thought to transport retinoids between the retinal pigment epithelium and the photoreceptors, a critical role in the visual process.The human IRBP gene is approximately 9.5 kbp in length and consists of four exons separated by three introns. The introns are 1.6-1.9 kbp long. The gene is transcribed by photoreceptor and retinoblastoma cells into an approximately 4.3-kilobase mRNA that is translated and processed into a glycosylated protein of 135,000 Da. The amino acid sequence of human IRBP can be divided into four contiguous homology domains with 33-38% identity, suggesting a series of gene duplication events. In the gene, the boundaries of these domains are not defined by exon-intron junctions, as might have been expected. The first three homology domains and part of the fourth are all encoded by the first large exon, which is 3,180 base pairs long. The remainder of the fourth domain is encoded in the last three exons, which are 191, 143, and approximately 740 base pairs long, respectively. [provided by RefSeq, Jul 2008]
UniProt Comments for RBP
RBP3: IRBP shuttles 11-cis and all trans retinoids between the retinol isomerase in the pigment epithelium and the visual pigments in the photoreceptor cells of the retina. Belongs to the peptidase S41A family.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 10q11.2
Cellular Component: extracellular space; extracellular region; vesicle
Molecular Function: retinoid binding; serine-type peptidase activity; retinal binding; retinol binding
Biological Process: phototransduction, visible light; visual perception; transport; lipid metabolic process; retinoid metabolic process; proteolysis
Disease: Retinitis Pigmentosa 66; Retinitis Pigmentosa
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