|
| Product Name
|
|
Signal Transducer and Activator of Transcription 5B (STAT5B), ELISA Kit
|
| Also Known As
|
|
Sheep Signal Transducer and Activator of Transcription 5B ELISA Kit
|
| Product Gene Name
|
|
|
[Similar Products]
|
| Research Use Only
|
|
For Research Use Only. Not for use in diagnostic procedures.
|
 TOP
|
| Request for Current Manual Insert
|
|
 |
|
| Chromosome Location
|
|
Chromosome: 17; NC_000017.10 (40351195..40428424, complement). Location: 17q11.2
|
| OMIM
|
|
245590
|
| 3D Structure
|
|
ModBase 3D Structure for P51692
|
|
| Species Reactivity
|
|
Sheep
|
|
|
|
|
| Assay Type
|
|
Sandwich
|
|
|
| Preparation and Storage
|
|
Store all reagents at 2-8 degree C
|
| Product Note
|
|
Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
|
| Other Notes
|
|
Small volumes of STAT5B elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
|
| Searchable Terms for STAT5B purchase
|
|
MBS029561 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Signal Transducer and Activator of Transcription 5B (STAT5B) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing STAT5B. The ELISA analytical biochemical technique of the MBS029561 kit is based on STAT5B antibody-STAT5B antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect STAT5B antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, STAT5B. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
|
|
TOP
|
|
| NCBI/Uniprot data below describe general gene information for STAT5B. It may not necessarily be applicable to this product. |
| NCBI GI #
|
|
21618344
|
| NCBI GeneID
|
|
6777
|
| NCBI Accession #
|
|
NP_036580.2
|
[Other Products]
|
| NCBI GenBank Nucleotide #
|
|
NM_012448.3
|
[Other Products]
|
|
|
| UniProt Primary Accession #
|
|
P51692
|
[Other Products]
|
| UniProt Secondary Accession #
|
|
Q8WWS8
|
[Other Products]
|
| UniProt Related Accession #
|
|
P51692
|
[Other Products]
|
| Molecular Weight
|
|
89,866 Da
|
|
TOP
|
| NCBI Official Full Name
|
|
signal transducer and activator of transcription 5B
|
| NCBI Official Synonym Full Names
|
|
signal transducer and activator of transcription 5B
|
| NCBI Official Symbol
|
|
STAT5B
|
[Similar Products]
|
| NCBI Official Synonym Symbols
|
|
STAT5
|
[Similar Products]
|
| NCBI Protein Information
|
|
signal transducer and activator of transcription 5B; transcription factor STAT5B
|
| UniProt Protein Name
|
|
Signal transducer and activator of transcription 5B
|
| Protein Family
|
|
Signal transducer and activator of transcription
|
| UniProt Gene Name
|
|
STAT5B
|
[Similar Products]
|
| UniProt Entry Name
|
|
STA5B_HUMAN
|
|
|
| NCBI Summary for STAT5B
|
|
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. [provided by RefSeq, Jul 2008]
|
|
|
| UniProt Comments for STAT5B
|
|
STAT5B: transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases triggered by cytokines including IL2, IL3, GM-CSF, and various growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. Forms homo- or heterodimers that translocate into the nucleus where they regulate transcription.
Protein type: DNA-binding; Oncoprotein; Transcription factor
Chromosomal Location of Human Ortholog: 17q11.2
Cellular Component: nucleoplasm; cytoplasm; nucleus; cytosol
Molecular Function: protein dimerization activity; protein binding; signal transducer activity; double-stranded DNA binding; chromatin binding; transcription factor activity; protein phosphatase binding; glucocorticoid receptor binding
Biological Process: positive regulation of interleukin-2 biosynthetic process; T cell differentiation in the thymus; response to lipopolysaccharide; female pregnancy; positive regulation of multicellular organism growth; 2-oxoglutarate metabolic process; sequestering of lipid; allantoin metabolic process; natural killer cell differentiation; regulation of steroid metabolic process; acute-phase response; T cell homeostasis; Peyer's patch development; isoleucine metabolic process; positive regulation of natural killer cell proliferation; valine metabolic process; development of secondary female sexual characteristics; JAK-STAT cascade; regulation of transcription from RNA polymerase II promoter; response to ethanol; regulation of epithelial cell differentiation; positive regulation of transcription from RNA polymerase II promoter; taurine metabolic process; negative regulation of apoptosis; transcription from RNA polymerase II promoter; lactation; succinate metabolic process; oxaloacetate metabolic process; positive regulation of smooth muscle cell proliferation; progesterone metabolic process; fatty acid metabolic process; positive regulation of activated T cell proliferation; positive regulation of mitotic cell cycle; response to estradiol stimulus; positive regulation of natural killer cell differentiation; luteinization; development of secondary male sexual characteristics; creatinine metabolic process; positive regulation of gamma-delta T cell differentiation; negative regulation of erythrocyte differentiation; citrate metabolic process; regulation of multicellular organism growth; positive regulation of cell motility; positive regulation of natural killer cell mediated cytotoxicity; liver development; creatine metabolic process; cellular response to hormone stimulus; response to hypoxia; positive regulation of B cell differentiation; positive regulation of inflammatory response
Disease: Growth Hormone Insensitivity With Immunodeficiency
|
|
TOP
|
|
| Research Articles on STAT5B
|
|
1. Human STAT5b A630P mutation, like STAT5b F646S is prone to aggregation, as evidenced by its detection in the insoluble fraction, the presence of dimers and higher-order proto-aggregates.
|
|
TOP
|
| Precautions
|
|
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
|
| Disclaimer
|
|
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
|
|
TOP
|
|
| Products associated with STAT5B elisa kit | Pathways associated with STAT5B elisa kit |
|
|
|
| Diseases associated with STAT5B elisa kit |
|
|
|
|
|
TOP
|
ELISA Kit 
