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VWF elisa kit :: Sheep Von Willebrand Factor ELISA Kit

Scan QR to view Datasheet Catalog #    MBS014196 VWF elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Von Willebrand Factor (VWF), ELISA Kit

 Also Known As   

Sheep Von Willebrand Factor ELISA Kit

 Product Gene Name   

VWF elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 12; NC_000012.11 (6058040..6233836, complement). Location: 12p13.3
 OMIM    193400
 3D Structure    ModBase 3D Structure for P04275
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 Species Reactivity    Sheep
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of VWF elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for VWF purchase    MBS014196 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Von Willebrand Factor (VWF) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing VWF. The ELISA analytical biochemical technique of the MBS014196 kit is based on VWF antibody-VWF antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect VWF antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, VWF. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for VWF. It may not necessarily be applicable to this product.
 NCBI GI #    89191868
 NCBI GeneID    7450
 NCBI Accession #    NP_000543.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000552.3 [Other Products]
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 UniProt Primary Accession #    P04275 [Other Products]
 UniProt Secondary Accession #    Q99806 [Other Products]
 UniProt Related Accession #    P04275 [Other Products]
 Molecular Weight    309,265 Da
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 NCBI Official Full Name    von Willebrand factor preproprotein
 NCBI Official Synonym Full Names    von Willebrand factor
 NCBI Official Symbol    VWF [Similar Products]
 NCBI Official Synonym Symbols   
VWD; F8VWF
[Similar Products]
 NCBI Protein Information    von Willebrand factor; coagulation factor VIII VWF
 UniProt Protein Name    von Willebrand factor
 UniProt Synonym Protein Names   
von Willebrand antigen II
 Protein Family    von Willebrand factor
 UniProt Gene Name    VWF [Similar Products]
 UniProt Synonym Gene Names    F8VWF; vWF [Similar Products]
 UniProt Entry Name    VWF_HUMAN
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 NCBI Summary for VWF    The glycoprotein encoded by this gene functions as both an antihemophilic factor carrier and a platelet-vessel wall mediator in the blood coagulation system. It is crucial to the hemostasis process. Mutations in this gene or deficiencies in this protein result in von Willebrand's disease. An unprocessed pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008]
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 UniProt Comments for VWF    VWF: Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma. Defects in VWF are the cause of von Willebrand disease type 1 (VWD1). A common hemorrhagic disorder due to defects in von Willebrand factor protein and resulting in impaired platelet aggregation. Von Willebrand disease type 1 is characterized by partial quantitative deficiency of circulating von Willebrand factor, that is otherwise structurally and functionally normal. Clinical manifestations are mucocutaneous bleeding, such as epistaxis and menorrhagia, and prolonged bleeding after surgery or trauma. Defects in VWF are the cause of von Willebrand disease type 2 (VWD2). A hemorrhagic disorder due to defects in von Willebrand factor protein and resulting in impaired platelet aggregation. Von Willebrand disease type 2 is characterized by qualitative deficiency and functional anomalies of von Willebrand factor. It is divided in different subtypes including 2A, 2B, 2M and 2N (Normandy variant). The mutant VWF protein in types 2A, 2B and 2M are defective in their platelet- dependent function, whereas the mutant protein in type 2N is defective in its ability to bind factor VIII. Clinical manifestations are mucocutaneous bleeding, such as epistaxis and menorrhagia, and prolonged bleeding after surgery or trauma. Defects in VWF are the cause of von Willebrand disease type 3 (VWD3). A severe hemorrhagic disorder due to a total or near total absence of von Willebrand factor in the plasma and cellular compartments, also leading to a profound deficiency of plasmatic factor VIII. Bleeding usually starts in infancy and can include epistaxis, recurrent mucocutaneous bleeding, excessive bleeding after minor trauma, and hemarthroses.

Protein type: Motility/polarity/chemotaxis; Secreted, signal peptide; Cell adhesion; Secreted; Extracellular matrix

Chromosomal Location of Human Ortholog: 12p13.3

Cellular Component: extracellular matrix; proteinaceous extracellular matrix; endoplasmic reticulum; extracellular region; external side of plasma membrane

Molecular Function: collagen binding; integrin binding; identical protein binding; protein binding; protein homodimerization activity; protease binding; chaperone binding; protein N-terminus binding; immunoglobulin binding; glycoprotein binding

Biological Process: platelet activation; extracellular matrix organization and biogenesis; platelet degranulation; hemostasis; response to wounding; blood coagulation; cell adhesion; liver development; blood coagulation, intrinsic pathway; cell-substrate adhesion; protein homooligomerization; placenta development

Disease: Von Willebrand Disease, Type 3; Von Willebrand Disease, Type 1; Von Willebrand Disease, Type 2
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 Research Articles on VWF    1. These findings implicate a role for intronic splicing in mediating lineage-specific expression of vWF in the endothelium.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with VWF elisa kitPathways associated with VWF elisa kit
 Reference Product  PubMed Publications
 ADAMTS13 elisa kit  >541 publications with VWF and ADAMTS13
 VEGFA elisa kit  >41 publications with VWF and VEGFA
 GP1BA elisa kit  >13 publications with VWF and GP1BA
 ITGA2B elisa kit  >6 publications with VWF and ITGA2B
 GATA2 elisa kit  >1 publications with VWF and GATA2
 Products by Pathway  Pathway Diagram
 Blood Clotting Cascade Pathway antibodies  Blood Clotting Cascade Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies  Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram
Diseases associated with VWF elisa kitOrgans/Tissues associated with VWF elisa kit
 Disease Name  Pubmed Publications
 Vascular Diseases Antibodies  >1850 publications with VWF and Vascular Diseases
 Cardiovascular Diseases Antibodies  >1825 publications with VWF and Cardiovascular Diseases
 Thrombosis Antibodies  >1305 publications with VWF and Thrombosis
 Heart Diseases Antibodies  >576 publications with VWF and Heart Diseases
 Inflammation Antibodies  >517 publications with VWF and Inflammation
 Neoplasms Antibodies  >423 publications with VWF and Neoplasms
 Kidney Diseases Antibodies  >303 publications with VWF and Kidney Diseases
 Hypertension Antibodies  >268 publications with VWF and Hypertension
 Necrosis Antibodies  >235 publications with VWF and Necrosis
 Anemia Antibodies  >223 publications with VWF and Anemia
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >5482 publications with VWF and Blood
 Vascular Antibodies  >2735 publications with VWF and Vascular
 Heart Antibodies  >572 publications with VWF and Heart
 Muscle Antibodies  >329 publications with VWF and Muscle
 Bone Antibodies  >293 publications with VWF and Bone
 Kidney Antibodies  >276 publications with VWF and Kidney
 Umbilical Cord Antibodies  >244 publications with VWF and Umbilical Cord
 Liver Antibodies  >242 publications with VWF and Liver
 Brain Antibodies  >231 publications with VWF and Brain
 Skin Antibodies  >223 publications with VWF and Skin
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