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ACAN elisa kit :: aggrecan ELISA Kit

Scan QR to view Datasheet Catalog #    MBS9323417 ACAN elisa kit
Unit / Price
48-Strip-Wells  /  $470 +1 FREE 8GB USB
96-Strip-Wells  /  $680 +1 FREE 8GB USB
5x96-Strip-Wells  /  $3,100 +3 FREE 8GB USB
10x96-Strip-Wells  /  $6,095 +7 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

aggrecan (ACAN), ELISA Kit

★Popular Item★
 Also Known As   

Mouse Aggrecan core protein (ACAN) ELISA Kit

 Product Gene Name   

ACAN elisa kit

[Similar Products]
 Product Synonym Gene Name    AGC1; AGCAN; CSPG1; CSPGCP; MSK16; SEDK; cartilage-specific proteoglycan core protein|chondroitin sulfate proteoglycan 1|large aggregating proteoglycan [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 7; NC_000073.6 (79053483..79115099). Location: 7 D3; 7 39.0 cM
 3D Structure    ModBase 3D Structure for Q61282
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 Specificity    No significant cross-reactivity or interference between this analyte and analogues is observed.
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 Samples    Body fluids, tissue homogenates, secretions or feces samples
 Assay Type    Quantitative Sandwich
 Detection Range    3.12 ng/ml - 100 ng/ml
 Sensitivity    1.0 ng/ml.
 Intra-assay Precision    Intra-assay CV (%) is less than 15%
 Inter-assay Precision    Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean 100].
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of ACAN elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for ACAN purchase    MBS9323417 is a ready-to-use microwell, strip plate Quantitative Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the aggrecan (ACAN) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 3.12 ng/ml - 100 ng/ml in biological research samples containing ACAN, with an estimated sensitivity of 1.0 ng/ml. The ELISA analytical biochemical technique of the MBS9323417 kit is based on ACAN antibody-ACAN antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ACAN antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ACAN. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Body fluids, tissue homogenates, secretions or feces samples. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for ACAN elisa kit

   Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of ACAN (hereafter termed "analyte") in undiluted original Mouse body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
Sample Manual Insert of MBS9323417. Click to request current manual
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NCBI/Uniprot data below describe general gene information for ACAN. It may not necessarily be applicable to this product.
 NCBI GI #    116875858
 NCBI GeneID    11595
 NCBI Accession #    NP_031450.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_007424.2 [Other Products]
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 UniProt Primary Accession #    Q61282 [Other Products]
 UniProt Secondary Accession #    Q64021; E9QLS9 [Other Products]
 UniProt Related Accession #    Q61282 [Other Products]
 Molecular Weight    221,941 Da
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 NCBI Official Full Name    aggrecan core protein
 NCBI Official Synonym Full Names    aggrecan
 NCBI Official Symbol    Acan [Similar Products]
 NCBI Official Synonym Symbols   
Agc; cmd; Agc1; Cspg1
[Similar Products]
 NCBI Protein Information    aggrecan core protein; CSPCP; aggrecan 1; cartilage-specific proteoglycan core protein
 UniProt Protein Name    Aggrecan core protein
 UniProt Synonym Protein Names   
Cartilage-specific proteoglycan core protein
 Protein Family    Aggrecan core protein
 UniProt Gene Name    Acan [Similar Products]
 UniProt Synonym Gene Names    Agc; Agc1; CSPCP [Similar Products]
 UniProt Entry Name    PGCA_MOUSE
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 UniProt Comments for ACAN    ACAN: This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. Defects in ACAN are the cause of spondyloepiphyseal dysplasia type Kimberley (SEDK). Spondyloepiphyseal dysplasias are a heterogeneous group of congenital chondrodysplasias that specifically affect epiphyses and vertebrae. The autosomal dominant SEDK is associated with premature degenerative arthropathy. Defects in ACAN are the cause of spondyloepimetaphyseal dysplasia aggrecan type (SEMD-ACAN). A bone disease characterized by severe short stature, macrocephaly, severe midface hypoplasia, short neck, barrel chest and brachydactyly. The radiological findings comprise long bones with generalized irregular epiphyses with widened metaphyses, especially at the knees, platyspondyly, and multiple cervical-vertebral clefts. Defects in ACAN are the cause of osteochondritis dissecans short stature and early-onset osteoarthritis (OD). It is a type of osteochondritis defined as a separation of cartilage and subchondral bone from the surrounding tissue, primarily affecting the knee, ankle and elbow joints. It is clinically characterized by multiple osteochondritic lesions in knees and/or hips and/or elbows, disproportionate short stature and early-onset osteoarthritis. Belongs to the aggrecan/versican proteoglycan family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Extracellular matrix; Secreted, signal peptide; Secreted

Cellular Component: proteinaceous extracellular matrix; extracellular region; basement membrane

Molecular Function: protein binding; extracellular matrix structural constituent; metal ion binding; hyaluronic acid binding; calcium ion binding; carbohydrate binding

Biological Process: central nervous system development; collagen fibril organization; proteoglycan biosynthetic process; chondrocyte development; cell adhesion; negative regulation of cell migration; cartilage condensation
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 Research Articles on ACAN    1. The role of ADAMTS5 in tendon is to remove pericellular and interfibrillar aggrecan to maintain the molecular architecture responsible for normal tissue function.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with ACAN elisa kitDiseases associated with ACAN elisa kit
 Products by Pathway  Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
 Disease Name  Pubmed Publications
 Osteoarthritis Antibodies  >20 publications with ACAN and Osteoarthritis
 Arthritis Antibodies  >18 publications with ACAN and Arthritis
 Necrosis Antibodies  >3 publications with ACAN and Necrosis
 Pain Antibodies  >3 publications with ACAN and Pain
 Arthritis, Rheumatoid Antibodies  >3 publications with ACAN and Arthritis, Rheumatoid
 Nervous System Diseases Antibodies  >3 publications with ACAN and Nervous System Diseases
 Growth Disorders Antibodies  >2 publications with ACAN and Growth Disorders
 Peripheral Nervous System Diseases Antibodies  >1 publications with ACAN and Peripheral Nervous System Diseases
 Weight Loss Antibodies  >1 publications with ACAN and Weight Loss
 Liver Diseases Antibodies  >1 publications with ACAN and Liver Diseases
Organs/Tissues associated with ACAN elisa kit
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >10 publications with ACAN and Brain
 Embryonic Tissue Antibodies  >3 publications with ACAN and Embryonic Tissue
 Skin Antibodies  >2 publications with ACAN and Skin
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