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ACAN elisa kit :: aggrecan ELISA Kit

Scan QR to view Datasheet Catalog #    MBS9333952 ACAN elisa kit
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

aggrecan (ACAN), ELISA Kit

 Also Known As   

Dog Aggrecan core protein (ACAN) ELISA Kit

 Product Gene Name   

ACAN elisa kit

[Similar Products]
 Product Synonym Gene Name    AGC1; AGCAN; CSPG1; CSPGCP; MSK16; SEDK; cartilage-specific proteoglycan core protein|chondroitin sulfate proteoglycan 1|large aggregating proteoglycan [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 3; NC_006585.3 (51995115..52031544). Location: chromosome: 3
 3D Structure    ModBase 3D Structure for Q28343
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of ACAN elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for ACAN purchase    MBS9333952 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the aggrecan (ACAN) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing ACAN. The ELISA analytical biochemical technique of the MBS9333952 kit is based on ACAN antibody-ACAN antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ACAN antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ACAN. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for ACAN. It may not necessarily be applicable to this product.
 NCBI GI #    164665422
 NCBI GeneID    403828
 NCBI Accession #    NP_001106926.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001113455.1 [Other Products]
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 UniProt Primary Accession #    Q28343 [Other Products]
 UniProt Secondary Accession #    Q28310 [Other Products]
 UniProt Related Accession #    Q28343 [Other Products]
 Molecular Weight    240,576 Da
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 NCBI Official Full Name    aggrecan core protein
 NCBI Official Symbol    ACAN [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    aggrecan core protein; CSPCP; aggrecan 1; chondroitin sulfate proteoglycan 1; large aggregating proteoglycan, antigen; cartilage-specific proteoglycan core protein
 UniProt Protein Name    Aggrecan core protein
 UniProt Synonym Protein Names   
Cartilage-specific proteoglycan core protein
 Protein Family    Aggrecan core protein
 UniProt Gene Name    ACAN [Similar Products]
 UniProt Synonym Gene Names    AGC1; CSPCP [Similar Products]
 UniProt Entry Name    PGCA_CANFA
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 UniProt Comments for ACAN    Function: This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.

Subunit structure: Interacts with FBLN1 and COMP

By similarity.

Subcellular location: Secreted › extracellular space › extracellular matrix

By similarity.

Domain: Two globular domains, G1 and G2, comprise the N-terminus of the proteoglycan, while another globular region, G3, makes up the C-terminus. G1 contains Link domains and thus consists of three disulfide-bonded loop structures designated as the A, B, B' motifs. G2 is similar to G1. The keratan sulfate (KS) and the chondroitin sulfate (CS) attachment domains lie between G2 and G3.

Post-translational modification: Contains mostly chondroitin sulfate, but also keratan sulfate chains, N-linked and O-linked oligosaccharides

By similarity.

Sequence similarities: Belongs to the aggrecan/versican proteoglycan family.Contains 1 C-type lectin domain.Contains 1 EGF-like domain.Contains 1 Ig-like V-type (immunoglobulin-like) domain.Contains 4 Link domains.Contains 1 Sushi (CCP/SCR) domain.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with ACAN elisa kit
 Disease Name  Pubmed Publications
 Osteoarthritis Antibodies  >20 publications with ACAN and Osteoarthritis
 Arthritis Antibodies  >18 publications with ACAN and Arthritis
 Necrosis Antibodies  >3 publications with ACAN and Necrosis
 Pain Antibodies  >3 publications with ACAN and Pain
 Arthritis, Rheumatoid Antibodies  >3 publications with ACAN and Arthritis, Rheumatoid
 Nervous System Diseases Antibodies  >3 publications with ACAN and Nervous System Diseases
 Growth Disorders Antibodies  >2 publications with ACAN and Growth Disorders
 Peripheral Nervous System Diseases Antibodies  >1 publications with ACAN and Peripheral Nervous System Diseases
 Weight Loss Antibodies  >1 publications with ACAN and Weight Loss
 Liver Diseases Antibodies  >1 publications with ACAN and Liver Diseases
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