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sAPPalpha elisa kit

Scan QR to view Datasheet Catalog #    MBS490143
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
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 Product Name   

sAPPalpha, ELISA Kit

★Popular Item★
 Also Known As   

sAPPalpha (Mouse/Rat) (highly sensitive) ELISA

 Product Synonym Names    Soluble Amyloid Precursor Protein Alpha
 Product Gene Name   

sAPPalpha elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
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 Assay Type    Sandwich
 Detection Range    4.1 - 260 pg/mL
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 Preparation and Storage    Store at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of sAPPalpha elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for sAPPalpha purchase    MBS490143 is a ready-to-use microwell, strip-or-full plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the sAPPalpha, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 4.1 - 260 pg/mL in biological research samples containing sAPPalpha. The ELISA analytical biochemical technique of the MBS490143 kit is based on sAPPalpha antibody-sAPPalpha antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect sAPPalpha antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, sAPPalpha. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for sAPPalpha elisa kit

   Principle of the Assay: This kit is a solid phase sandwich ELISA using 2 kinds of highly specific antibodies. Tetra Methyl Benzidine (TMB) is used as a coloring agent (Chromogen). The strength of coloring is proportional to the quantities of Mouse/Rat sAPPalpha.

Background: Alzheimer"s disease (AD) was first reported by A. Alzheimer, a German neuropathologist in 1907 and is considered as a major factor of dementia. It is known that Amyloid beta (Abeta; which is major constituent of senile plaque) is cleaved from Amyloid Precursor Protein (APP; which exists in three main isoforms, APP695, APP751, and APP770) by beta-secretase and subsequent gamma-secretase (ref. 1). The production of soluble APPbeta (sAPPbeta) by beta-secretase cleavage corresponds to Abeta production accordingly, so it is desired to measure sAPPbeta in parallel with Abeta. On the other hand, it is considered that in the metabolic pathway of APP, APP is first cleaved by alpha-secretase rather than beta-secretase normally to produce soluble APPalpha (sAPPalpha) and subsequently P3 is cleaved from the remaining C-terminal fragment by gamma-secretase. In recent research, there are several attempts to apply the inhibitor of beta-secretase and the activation of alpha-secretase for AD treatment. As stated above, it is useful for research of AD to measure sAPPalpha as well as sAPPbeta. This kit can measure Mouse/Rat sAPPalpha. Note: Please pay attention in sample selection since this kit also measures full-length APP.
 Product Categories/Family for sAPPalpha elisa kit    Brain Disorders & Neuroscience; Research Assays; Assay Categories
 Application Notes for sAPPalpha elisa kit    Overnight incubation (4 degree C) + 1 hour (4 degree C) + 30 min. (RT) = Overnight + 1 hour, 30 min. total incubation time.
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 Typical Testing Data/Standard Curve (for reference only) of sAPPalpha elisa kit    sAPPalpha elisa kit Typical Testing Data/Standard Curve (for reference only) image
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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