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VTN elisa kit :: vitronectin total antigen assay ELISA Kit

Scan QR to view Datasheet Catalog #    MBS135526
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
1 Kit  /  $540 +1 FREE 8GB USB
5 Kits  /  $1,930 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

vitronectin total antigen assay (VTN), ELISA Kit

 Also Known As   

Mouse vitronectin total antigen assay ELISA Kit

 Product Gene Name   

VTN elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 11; NC_000077.6 (78499120..78502325). Location: 11 B5; 11 46.74 cM
 3D Structure    ModBase 3D Structure for P29788
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 Host    Multiple
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 Form/Format    Complete Kit
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 Samples    Biological fluids
 Intra-assay Precision    These studies are currently in progress. Please contact us for more information.
 Inter-assay Precision    These studies are currently in progress. Please contact us for more information.
 Intended Uses    This mouse vitronectin total antigen assay is for the quantitative determination of total vitronectin antigen in biological fluids. For research use only.
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 Preparation and Storage    Store at 4 degree C. Shelf Life: 6 months from manufacture, see label for expiration date
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of VTN elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for VTN purchase    MBS135526 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Multiple vitronectin total antigen assay (VTN) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing VTN. The ELISA analytical biochemical technique of the MBS135526 kit is based on VTN antibody-VTN antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect VTN antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, VTN. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Biological fluids. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for VTN elisa kit

   Principle of the Assay: Mouse vitronectin will bind to the affinity purified capture antibody coated on the microtiter plate. Free and ligand bound enzyme will react with the antibody on the plate. After appropriate washing steps, biotinylated anti-mouse vitronectin primary antibody binds to the captured protein. Excess antibody is washed away and bound polyclonal antibody is reacted with peroxidase conjugated streptavidin. Following an additional washing step, TMB substrate is used for color development at 450nm. A standard calibration curve is prepared along with the samples to be measured using dilutions of mouse vitronectin. The amount of color development is directly proportional to the concentration of total vitronectin in the sample.
Background: Vitronectin is an abundant plasma glycoprotein that helps regulate coagulation, fibrinolysis, complement activation, and cell adhesion [1,3,7]. Vitronectin binds to glycosaminoglycans, collagen, plasminogen and urokinase receptors. It also may control the clearance of vascular thrombi by binding and stabilizing PAI-1. In binding PAI-1, it extends the lifetime of active PAI-1 [4,5]. Vitronectin may also be involved in the regulation of bone metabolism [2].
 Product Categories/Family for VTN elisa kit    Vitronectin; Mouse Vitronectin Elisa Kit
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 Typical Testing Data/Standard Curve (for reference only) of VTN elisa kit    VTN elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS135526. Click to request current manual
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NCBI/Uniprot data below describe general gene information for VTN. It may not necessarily be applicable to this product.
 NCBI GI #    6755987
 NCBI GeneID    22370
 NCBI Accession #    NP_035837.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_011707.2 [Other Products]
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 UniProt Primary Accession #    P29788 [Other Products]
 UniProt Secondary Accession #    Q5SYG4; Q8VII4; Q91X32; Q9D080 [Other Products]
 UniProt Related Accession #    P29788 [Other Products]
 Molecular Weight    54,849 Da
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 NCBI Official Full Name    vitronectin
 NCBI Official Synonym Full Names    vitronectin
 NCBI Official Symbol    Vtn [Similar Products]
 NCBI Official Synonym Symbols   
Vn; AI256434
[Similar Products]
 NCBI Protein Information    vitronectin; S-protein; serum-spreading factor
 UniProt Protein Name    Vitronectin
 UniProt Synonym Protein Names   
S-protein; Serum-spreading factor
 Protein Family    Vitronectin
 UniProt Gene Name    Vtn [Similar Products]
 UniProt Synonym Gene Names    VN [Similar Products]
 UniProt Entry Name    VTNC_MOUSE
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 UniProt Comments for VTN    VTN: Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.

Protein type: Motility/polarity/chemotaxis; Secreted, signal peptide; Cell adhesion; Secreted

Cellular Component: extracellular matrix; extracellular space; proteinaceous extracellular matrix; extracellular region

Molecular Function: integrin binding; heparin binding; extracellular matrix binding; scavenger receptor activity; polysaccharide binding

Biological Process: positive regulation of peptidyl-tyrosine phosphorylation; extracellular matrix organization and biogenesis; positive regulation of protein binding; cell-matrix adhesion; cell adhesion mediated by integrin; immune response; positive regulation of smooth muscle cell migration; cell adhesion; positive regulation of receptor-mediated endocytosis
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 Research Articles on VTN    1. Vitronectin inhibits efferocytosis through interactions with apoptotic cells as well as with macrophages.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with VTN elisa kitDiseases associated with VTN elisa kit
 Products by Pathway  Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 Elastic Fibre Formation Pathway antibodies  Elastic Fibre Formation Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Inflammatory Response Pathway antibodies  Inflammatory Response Pathway Diagram
 Integrin Cell Surface Interactions Pathway antibodies  Integrin Cell Surface Interactions Pathway Diagram
 Molecules Associated With Elastic Fibres Pathway antibodies  Molecules Associated With Elastic Fibres Pathway Diagram
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >3 publications with VTN and Cardiovascular Diseases
 Kidney Diseases Antibodies  >2 publications with VTN and Kidney Diseases
 Heart Diseases Antibodies  >2 publications with VTN and Heart Diseases
 Drug Toxicity Antibodies  >2 publications with VTN and Drug Toxicity
 Weight Loss Antibodies  >2 publications with VTN and Weight Loss
 Nervous System Diseases Antibodies  >1 publications with VTN and Nervous System Diseases
 Fibrosis Antibodies  >1 publications with VTN and Fibrosis
 Proteinuria Antibodies  >1 publications with VTN and Proteinuria
 Hypertension Antibodies  >1 publications with VTN and Hypertension
 Atherosclerosis Antibodies  >1 publications with VTN and Atherosclerosis
Organs/Tissues associated with VTN elisa kit
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >14 publications with VTN and Brain
 Heart Antibodies  >5 publications with VTN and Heart
 Muscle Antibodies  >4 publications with VTN and Muscle
 Lung Antibodies  >4 publications with VTN and Lung
 Kidney Antibodies  >3 publications with VTN and Kidney
 Eye Antibodies  >2 publications with VTN and Eye
 Pancreas Antibodies  >1 publications with VTN and Pancreas
 Embryonic Tissue Antibodies  >1 publications with VTN and Embryonic Tissue
 Liver Antibodies  >1 publications with VTN and Liver
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