NP_032363.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
17,907 Da
NCBI Official Full Name
interferon gamma
NCBI Official Synonym Full Names
interferon gamma
NCBI Official Synonym Symbols
NCBI Protein Information
interferon gamma
UniProt Protein Name
Interferon gamma
UniProt Synonym Gene Names
UniProt Entry Name
IFNG_MOUSE
NCBI Summary for IFN gamma
This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of the both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial inflections. Mice deficient in this gene have increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. [provided by RefSeq, Sep 2015]
UniProt Comments for IFN gamma
IFNG: Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. Homodimer. Released primarily from activated T lymphocytes. Belongs to the type II (or gamma) interferon family.
Protein type: Secreted; Secreted, signal peptide; Membrane protein, integral; Cytokine
Cellular Component: extracellular space; cell; extracellular region; intracellular; external side of plasma membrane
Molecular Function: protein binding; interferon-gamma receptor binding; cytokine activity
Biological Process: positive regulation of isotype switching to IgG isotypes; positive regulation of cell adhesion; positive regulation of nitric oxide biosynthetic process; positive regulation of osteoclast differentiation; positive regulation of interleukin-23 production; positive regulation of transcription, DNA-dependent; negative regulation of epithelial cell differentiation; positive regulation of killing of cells of another organism; positive regulation of interleukin-1 beta secretion; positive regulation of membrane protein ectodomain proteolysis; regulation of growth; positive regulation of T cell proliferation; cell cycle arrest; defense response to virus; regulation of the force of heart contraction; positive regulation of peptidyl-serine phosphorylation of STAT protein; neutrophil chemotaxis; positive regulation of synaptic transmission, cholinergic; CD8-positive, alpha-beta T cell differentiation during immune response; negative regulation of myelination; response to virus; positive regulation of tumor necrosis factor production; defense response to protozoan; inflammatory cell apoptosis; positive regulation of tyrosine phosphorylation of Stat1 protein; defense response to bacterium; neutrophil apoptosis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of interleukin-12 production; negative regulation of smooth muscle cell proliferation; apoptosis; positive regulation of interleukin-6 biosynthetic process; sensory perception of mechanical stimulus; negative regulation of transcription from RNA polymerase II promoter; negative regulation of cell proliferation; regulation of transcription, DNA-dependent; positive regulation of MHC class II biosynthetic process; positive regulation of cell proliferation; adaptive immune response; regulation of immune response; unfolded protein response; humoral immune response; antigen processing and presentation; positive regulation of interleukin-12 biosynthetic process; positive regulation of chemokine biosynthetic process; negative regulation of interleukin-17 production; protein import into nucleus, translocation; immune response; positive regulation of neuron differentiation; regulation of insulin secretion
Product References and Citations for IFN gamma elisa set
Audran, R. et al., Infect Immun., 2005; 73(12): 8017-26. Filaci, G. et al., J. Immunol.,2007; 179(7): 4323-4334 Haller D. et al., Clin. Diagn. Lab. Immunol., 2002; 9(3): 649 - 657
Research Articles on IFN gamma
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Products associated with IFN gamma elisa set
Pathways associated with IFN gamma elisa set
Diseases associated with IFN gamma elisa set
Organs/Tissues associated with IFN gamma elisa set
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