P05186
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
57,305 Da
NCBI Official Full Name
alkaline phosphatase
NCBI Official Synonym Full Names
alkaline phosphatase, liver/bone/kidney
NCBI Official Synonym Symbols
HOPS; TNAP; APTNAP; TNSALP; AP-TNAP; FLJ40094; FLJ93059; MGC161443; MGC167935 [Similar Products]
NCBI Protein Information
alkaline phosphatase, tissue-nonspecific isozyme; OTTHUMP00000002971; OTTHUMP00000002972; glycerophosphatase; tissue-nonspecific ALP; alkaline phosphomonoesterase; liver/bone/kidney-type alkaline phosphatase; alkaline phosphatase liver/bone/kidney isozyme
UniProt Protein Name
Alkaline phosphatase, tissue-nonspecific isozyme
UniProt Synonym Protein Names
Alkaline phosphatase liver/bone/kidney isozyme
UniProt Entry Name
PPBT_HUMAN
NCBI Summary for ALP
There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants have been described. [provided by RefSeq]
UniProt Comments for ALP
Function: This isozyme may play a role in skeletal mineralization.
Catalytic activity: A phosphate monoester + H2O = an alcohol + phosphate.
Cofactor: Binds 1 magnesium ion
By similarity.Binds 2 zinc ions
Subunit structure: Homodimer.
Subcellular location: Cell membrane; Lipid-anchor › GPI-anchor Ref.10 Ref.11.
Post-translational modification: Glycosylated. Ref.9 Ref.12
Involvement in disease: Defects in ALPL are a cause of hypophosphatasia (HOPS) [
MIM:146300]. HOPS is an inherited metabolic bone disease characterized by defective skeletal mineralization. Four hypophosphatasia forms are distinguished, depending on the age of onset: perinatal, infantile, childhood and adult type. The perinatal form is the most severe and is almost always fatal. Patients with only premature loss of deciduous teeth, but with no bone disease are regarded as having odontohypophosphatasia (odonto). Ref.4 Ref.13 Ref.14 Ref.15 Ref.16 Ref.17 Ref.18 Ref.19 Ref.20 Ref.21 Ref.22 Ref.23 Ref.24 Ref.25 Ref.26 Ref.27 Ref.28 Ref.29 Ref.30 Ref.31 Ref.32 Ref.33 Ref.34 Ref.35Defects in ALPL are a cause of hypophosphatasia childhood type (HOPSC) [
MIM:241510].Defects in ALPL are a cause of hypophosphatasia infantile type (HOPSI) [
MIM:241500].
Sequence similarities: Belongs to the alkaline phosphatase family.
Sequence caution: The sequence BAD93051.1 differs from that shown. Reason: Erroneous initiation.
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Pathways associated with ALP enzyme
Diseases associated with ALP enzyme
Organs/Tissues associated with ALP enzyme
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