NP_036661.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
creatine kinase B-type
NCBI Official Synonym Full Names
creatine kinase, brain
NCBI Official Synonym Symbols
NCBI Protein Information
creatine kinase B-type; B-CK; brain creatine kinase; creatine kinase B chain
UniProt Protein Name
Creatine kinase B-type
UniProt Synonym Protein Names
B-CK; Creatine kinase B chain
UniProt Synonym Gene Names
UniProt Entry Name
KCRB_RAT
NCBI Summary for Ckb
brain specific isozyme that catalyzed the interconversion of ATP and creatine to ADP and phosphocreatine; may play a role in ATP generation during cerebellar development [RGD, Feb 2006]
UniProt Comments for Ckb
Function: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
Catalytic activity: ATP + creatine = ADP + phosphocreatine.
Subunit structure: Dimer of identical or non-identical chains. With MM being the major form in skeletal muscle and myocardium, MB existing in myocardium, and BB existing in many tissues, especially brain.
Subcellular location: Cytoplasm.
Tissue specificity: In the kidney localized primarily in the outer medulla in the thick ascending limb and distal convoluted tubule. Ref.7
Sequence similarities: Belongs to the ATP:guanido phosphotransferase family.Contains 1 phosphagen kinase C-terminal domain.Contains 1 phosphagen kinase N-terminal domain.
Sequence caution: The sequence AAH87656.1 differs from that shown. Reason: Erroneous initiation.
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Pathways associated with Ckb enzyme
Diseases associated with Ckb enzyme
Organs/Tissues associated with Ckb enzyme
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