AAA51706.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
placental alkaline phosphatase
NCBI Official Synonym Full Names
alkaline phosphatase, placental
NCBI Protein Information
alkaline phosphatase, placental type; Regan isozyme; glycerophosphatase; alkaline phosphomonoesterase; placental alkaline phosphatase 1; alkaline phosphatase Regan isozyme
UniProt Protein Name
Alkaline phosphatase, placental type
UniProt Synonym Protein Names
Alkaline phosphatase Regan isozyme; Placental alkaline phosphatase 1
UniProt Synonym Gene Names
UniProt Entry Name
PPB1_HUMAN
NCBI Summary for ALPP
There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2 while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme, also referred to as the heat stable form, that is expressed primarily in the placenta although it is closely related to the intestinal form of the enzyme as well as to the placental-like form. The coding sequence for this form of alkaline phosphatase is unique in that the 3' untranslated region contains multiple copies of an Alu family repeat. In addition, this gene is polymorphic and three common alleles (type 1, type 2 and type 3) for this form of alkaline phosphatase have been well characterized. [provided by RefSeq, Jul 2008]
UniProt Comments for ALPP
Catalytic activity: A phosphate monoester + H2O = an alcohol + phosphate.
Cofactor: Binds 1 magnesium ion
By similarity.Binds 2 zinc ions
By similarity.
Subunit structure: Homodimer.
Subcellular location: Cell membrane; Lipid-anchor › GPI-anchor Ref.10 Ref.11.
Polymorphism: Placental ALP is highly polymorphic, there are at least three common alleles.
Miscellaneous: In most mammals there are four different isozymes: placental, placental-like, intestinal and tissue non-specific (liver/bone/kidney).
Sequence similarities: Belongs to the alkaline phosphatase family.
Sequence caution: The sequence AAA51708.1 differs from that shown. Reason: Erroneous initiation.
Research Articles on ALPP
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Products associated with ALPP enzyme
Pathways associated with ALPP enzyme
Diseases associated with ALPP enzyme
Organs/Tissues associated with ALPP enzyme
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