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IGHD immunoglobulin :: IgD, Human Plasma Immunoglobulin

Scan QR to view Datasheet Catalog #    MBS135563
Testing Data
Unit / Price
0.025 mg  /  $360 +1 FREE 8GB USB
0.1 mg  /  $805 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IgD, Human Plasma (IGHD), Immunoglobulin

 Also Known As   

IgD, Human Plasma

 Product Gene Name   

IGHD immunoglobulin

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 14; NC_000014.8 (106304737..106312010, complement). Location: 14q32.33
 OMIM    147170
 3D Structure    ModBase 3D Structure for P01880
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 Host    Human plasma
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 Purity/Purification    >95% by SDS-PAGE analysis
 Form/Format    Frozen liquid
 Concentration    1.0 mg/ml (lot specific)
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 Buffer    0.01M Tris-HCl; 0.2M NaCl; 0.05% Sodium Azide; pH 8.0
 Extinction Coefficient    1.7
 Preservative    SodiumAzide
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 Preparation and Storage    Store at -70 degree C. Shelf Life: 3 years from delivery
 Other Notes    Small volumes of IGHD immunoglobulin vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for IGHD immunoglobulin

   IgD was first identified in 1965, and like other immunoglobulins, exists as both secreted and membrane forms. Its level in plasma is low with a mean concentration of 30 ug/ml. IgD is present in large quantities on the surface membrane of a majority of hum
 Product Categories/Family for IGHD immunoglobulin    Human Immunoglobulins; Human Immunoglobulins
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 Testing Data of IGHD immunoglobulin    IGHD immunoglobulin Testing Data image
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NCBI/Uniprot data below describe general gene information for IGHD. It may not necessarily be applicable to this product.
 NCBI GI #    193806360
 NCBI GeneID    3495
 NCBI Accession #    P01880.2 [Other Products]
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 UniProt Primary Accession #    P01880 [Other Products]
 UniProt Secondary Accession #    Q6P4I8; Q8WU38 [Other Products]
 UniProt Related Accession #    P01880 [Other Products]
 Molecular Weight    185,000
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 NCBI Official Full Name    Ig delta chain C region
 NCBI Official Synonym Full Names    immunoglobulin heavy constant delta
 NCBI Official Symbol    IGHD [Similar Products]
 UniProt Protein Name    Ig delta chain C region
 Protein Family    Ig delta chain C region
 UniProt Gene Name    IGHD [Similar Products]
 UniProt Entry Name    IGHD_HUMAN
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 UniProt Comments for IGHD    IGHD: IgD is the major antigen receptor isotype on the surface of most peripheral B-cells, where it is coexpressed with IgM. The membrane-bound IgD (mIgD) induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. Soluble IgD (sIgD) concentration in serum below those of IgG, IgA, and IgM but much higher than that of IgE. IgM and IgD molecules present on B cells have identical V regions and antigen-binding sites. After the antigen binds to the B-cell receptor, the secreted form sIgD is shut off. IgD is a potent inducer of TNF, IL1B, and IL1RN. IgD also induces release of IL6, IL10, and LIF from peripheral blood mononuclear cells. Monocytes seem to be the main producers of cytokines in vitro in the presence of IgD. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 14q32.33

Cellular Component: plasma membrane; integral to membrane

Molecular Function: antigen binding

Biological Process: immune response
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 Research Articles on IGHD    1. Role of surface IgM and IgD on survival/apoptosis of B-cell chronic lymphocytic leukemia cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with IGHD immunoglobulinOrgans/Tissues associated with IGHD immunoglobulin
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Activates B Cell Receptor Leading To Generation Of Second Messengers Pathway antibodies  Antigen Activates B Cell Receptor Leading To Generation Of Second Messengers Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Signaling By The B Cell Receptor (BCR) Pathway antibodies  Signaling By The B Cell Receptor (BCR) Pathway Diagram
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >104 publications with IGHD and Blood
 Brain Antibodies  >83 publications with IGHD and Brain
 Bone Antibodies  >41 publications with IGHD and Bone
 Thyroid Antibodies  >12 publications with IGHD and Thyroid
 Connective Tissue Antibodies  >6 publications with IGHD and Connective Tissue
 Skin Antibodies  >5 publications with IGHD and Skin
 Liver Antibodies  >5 publications with IGHD and Liver
 Vascular Antibodies  >4 publications with IGHD and Vascular
 Spleen Antibodies  >4 publications with IGHD and Spleen
 Bone Marrow Antibodies  >4 publications with IGHD and Bone Marrow
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