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AICAR inhibitor

Scan QR to view Datasheet Catalog #    MBS515046
Molecular Structure
Unit / Price
10 mg  /  $165 +1 FREE 8GB USB
50 mg  /  $205 +1 FREE 8GB USB
 
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 Product Name   

AICAR, Inhibitor

 Also Known As   

AICAR

 Product Synonym Names    ZM-447439; N-[4-[[6-Methoxy-7-[3-(4-morpholiny¬l)propoxy]-4-quinazolinyl]amino]phenyl]benzamide
 Product Gene Name   

AICAR inhibitor

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Purity/Purification    >98% (TLC); NMR (Conforms)
 Form/Format    Off white solid
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 CAS Number    2627-69-2
 Molecular Formula    C9H14N4O5
 Melting Point    213-214 degree C
 Activity    Aurora B kinase inhibitor
 Reconstitution    May be dissolved in DMSO (50 mg/ml)
 Solubilization    Soluble in DMSO (15 mg/ml); or water (15 mg/ml)
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 Preparation and Storage    Store desiccated as supplied at -20 degree C for up to 2 years. Store solutions at -20 degree C for up to 3 months.
 Other Notes    Small volumes of AICAR inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for AICAR inhibitor

   AMPK activator
Novel, selective ATP-competitive inhibitor of Aurora B kinase in vitro (IC50 values are 50, 250 and 1000 nM for Aurora B, C and A kinases respectively). Selective over a range of other kinases including cdk1 and PLK1 (IC50 > 10 uM). Inhibits cell division and displays selective toxicity towards proliferating tumor cells versus non-dividing cells.

Scientific Background: Activates AMP-activated protein kinase (AMPK). Promotes ligand-independent activation of the insulin receptor (1). Promotes skeletal muscle autophagy via activation of FoxO3a (2). Controls smooth muscle cell hyperproliferation in vascular disease (3). Cell permeable.
 Product Categories/Family for AICAR inhibitor    Inhibitors; Biochemicals - Kinase Activators
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 Molecular Structure of AICAR inhibitor    AICAR inhibitor Molecular Structure image
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 Molecular Weight    258.2
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Product References and Citations for AICAR inhibitor

   1. C Ditchfield et al J. Cell Biol. 2003 161:267 2. F Girdler et al J. Cell Sci. 2006 119:3664 3. F H Jung et al J. Med. Chem. 2006 49:955
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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