View our list of available Coronavirus (COVID-19, SARS-CoV-2, 2019-nCOV) antibodies, recombinant proteins, ELISA Kits... Options Full Datasheet Printer Friendly Datasheet Prepare for Printing Full Datasheet Printer Friendly Datasheet Prepare for Printing Have Questions? Ask Us! Request A Quote Today! Add To Compare List Alsterpaullone, Inhibitor Catalog # MBS515077 Unit / Price 1 mg / $295 +1 FREE 8GB USB 5 mg / $605 +1 FREE 8GB USB 5x5 mg / $2,335 +2 FREE 8GB USB Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name Alsterpaullone, Inhibitor Full Product Name Alsterpaullone Product Synonym Names A83-01; 3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide; 9-Nitro-7,12-dihydroindolo-[3,2-d][1] benzazepin-6(5)-one Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP Purity/Purification >98% (TLC); NMR (Conforms) Form/Format Brown crystalline powder CAS Number 237430-03-4 Molecular Formula C16H11N3O3 Activity ALK inhibitor Reconstitution May be dissolved in DMSO (20mg/ml) Solubilization May be dissolved in DMSO (10 mg/ml) Preparation and Storage Store desiccated as supplied at -20 degree C for up to 2 years. Store solutions at -20 degree C for up to 2 months. Other Notes Small volumes of Alsterpaullone, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Related Product Information for Alsterpaullone, inhibitor GSK-3beta and CDK5/p25 inhibitor.Potent and selective ALK4, 5 and 7 inhibitor1,2. IC50=45, 12, 7.5 nM respectively. Prevents phosphorylation of Smad2/3 and growth inhibition induced by TGF 2. Inhibits differentiation of rat induced pluripotent stem cells and increases clonal expansion efficiency3. Together with AMI-5 enabled Oct4-induced reprogramming of mouse embryonic fibroblasts4. Active in rat models. Cell permeable.Scientific Background: A potent and selective inhibitor of GSK-3beta and CDK5/p25. Potent inhibitor of CDK1/Cyclin B (IC50=35 nM) (1). Induces apoptosis (2). Inhibits angiogenesis (3). Product Categories/Family for Alsterpaullone, inhibitor Inhibitors; Biochemicals - Kinase Inhibitors Molecular Structure of Alsterpaullone, inhibitor TOP Molecular Weight 293.3[Similar Products] TOP Product References and Citations for Alsterpaullone, inhibitor 1. J Vogt et al. Cell Signal. 2011 23:18312. M Tojo et al. Cancer Sci. 2012 96:7913. W Li et al. Cell Stem Cell 2009 4:164. X Yuan et al. Stem Cells 2011 29:549 TOP Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information. TOP