View our list of available Coronavirus (COVID-19, SARS-CoV-2, 2019-nCOV) antibodies, recombinant proteins, ELISA Kits... Options Full Datasheet Printer Friendly Datasheet Prepare for Printing Full Datasheet Printer Friendly Datasheet Prepare for Printing Have Questions? Ask Us! Request A Quote Today! Add To Compare List COH29, inhibitor Catalog # MBS578213 Unit / Price 1 mg / $195 +1 FREE 8GB USB 2 mg / $230 +1 FREE 8GB USB 5 mg / $380 +1 FREE 8GB USB 25 mg / $910 +1 FREE 8GB USB 50 mg / $1,345 +1 FREE 8GB USB 100 mg / $1,855 +2 FREE 8GB USB 5x100 mg / $8,160 +10 FREE 8GB USB Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name COH29, Inhibitor Full Product Name COH29 Product Gene Name COH29, inhibitor[Similar Products] Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP Purity/Purification 98.9% Form/Format POWDER CAS 1190932-38-7 Smiles c1c(ccc(c1O)O)C(=O)Nc1nc(c(s1)c1ccccc1)c1cc(c(cc1)O)O Formula C22H16N2O5S Preparation and Storage Store at -20 degree C Other Notes Small volumes of COH29, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Related Product Information for COH29, inhibitor COH29 is an orally available, aromatically substituted thiazole and inhibitor of the human ribonucleotide reductase (RNR), with potential antineoplastic activity. Upon oral administration, the RNR inhibitor COH29 binds to the ligand-binding pocket of the RNR M2 subunit (hRRM2) near the C-terminal tail. This blocks the interaction between the hRRM1 and hRRM2 subunits and interferes with the assembly of the active hRRM1/hRRM2 complex of RNR. Inhibition of RNR activity decreases the pool of deoxyribonucleotide triphosphates available for DNA synthesis. The resulting decrease in DNA synthesis causes cell cycle arrest and growth inhibition. In addition, this agent may inhibit the nuclear enzyme poly (ADP-ribose) polymerase (PARP) 1, which prevents the repair of damaged DNA, and causes both the accumulation of single and double strand DNA breaks and the induction of apoptosis. Product Categories/Family for COH29, inhibitor Molecules; RNR inhibitor; PARP inhibitor; RNR inhibitor; PARP inhibitor; RNR inhibitor; PARP inhibitor Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information. TOP