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CTSB inhibitor :: Cathepsin B,L Inhibitor

Scan QR to view Datasheet Catalog #    MBS655413 CTSB inhibitor
Unit / Price
0.02 mL  /  $435 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Cathepsin B,L Inhibitor (CTSB), Inhibitor

 Also Known As   

Cathepsin B,L Inhibitor (Z-FF-FMK)

 Product Gene Name   

CTSB inhibitor

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    Z-Phe-Phe- FMK (FMK, fluorometh yl ketone)
 Chromosome Location    Chromosome: 8; AC_000165.1 (7402486..7423489). Location: chromosome: 8
 3D Structure    ModBase 3D Structure for P07688
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 Purity/Purification    Molecular Biology Grade
95% by HPLC analysis
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 Preparation and Storage    May be stored at 4 degree C for short-term only. For long-term storage, aliquot to avoid repeated freezing and thawing and freeze at -20 degree C. Aliquots are stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of CTSB inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for CTSB inhibitor

   Cathepsins are localized primarily in lysosomes or endosomes, but translocated to the cytosol during apoptosis. The translocation allows these proteases to interact with caspases or other apoptosis signaling mechanisms. Studies show that cathepsins cleave certain caspases, and caspase inhibitors can inhibit cathepsin activity in vitro.
 Product Categories/Family for CTSB inhibitor    Molecular Biology; MB-Cathepsin
NCBI/Uniprot data below describe general gene information for CTSB. It may not necessarily be applicable to this product.
 NCBI GI #    27806671
 NCBI GeneID    281105
 NCBI Accession #    NP_776456.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_174031.2 [Other Products]
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 UniProt Primary Accession #    P07688 [Other Products]
 UniProt Secondary Accession #    Q3ZC03 [Other Products]
 UniProt Related Accession #    P07688 [Other Products]
 Molecular Weight    462D [Similar Products]
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 NCBI Official Full Name    cathepsin B
 NCBI Official Synonym Full Names    cathepsin B
 NCBI Official Symbol    CTSB [Similar Products]
 NCBI Protein Information    cathepsin B; BCSB
 UniProt Protein Name    Cathepsin B
 UniProt Synonym Protein Names   
BCSB
 Protein Family    Cathepsin
 UniProt Gene Name    CTSB [Similar Products]
 UniProt Entry Name    CATB_BOVIN
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 UniProt Comments for CTSB    Function: Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.

Catalytic activity: Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially cleaves -Arg-Arg-|-Xaa bonds in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides.

Subunit structure: Interacts with SRPX2

By similarity. Dimer of a heavy chain and a light chain cross-linked by a disulfide bond.

Subcellular location: Lysosome. Melanosome

By similarity. Secreted › extracellular space

By similarity.

Sequence similarities: Belongs to the peptidase C1 family.
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 Research Articles on CTSB    1. The cathepsin B deserves further evaluation as therapeutic targets to develop disease modifying drugs to treat Alzheimer's disease.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with CTSB inhibitorDiseases associated with CTSB inhibitor
 Products by Pathway  Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway antibodies  Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway Diagram
 Collagen Formation Pathway antibodies  Collagen Formation Pathway Diagram
 Degradation Of Collagen Pathway antibodies  Degradation Of Collagen Pathway Diagram
 Degradation Of The Extracellular Matrix Pathway antibodies  Degradation Of The Extracellular Matrix Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >32 publications with CTSB and Inflammation
 Disease Models, Animal Antibodies  >26 publications with CTSB and Disease Models, Animal
 Necrosis Antibodies  >20 publications with CTSB and Necrosis
 Nervous System Diseases Antibodies  >20 publications with CTSB and Nervous System Diseases
 Liver Diseases Antibodies  >18 publications with CTSB and Liver Diseases
 Neoplasm Invasiveness Antibodies  >16 publications with CTSB and Neoplasm Invasiveness
 Cardiovascular Diseases Antibodies  >14 publications with CTSB and Cardiovascular Diseases
 Brain Diseases Antibodies  >13 publications with CTSB and Brain Diseases
 Lung Neoplasms Antibodies  >13 publications with CTSB and Lung Neoplasms
 Breast Neoplasms Antibodies  >10 publications with CTSB and Breast Neoplasms
Organs/Tissues associated with CTSB inhibitor
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >41 publications with CTSB and Blood
 Liver Antibodies  >26 publications with CTSB and Liver
 Lung Antibodies  >22 publications with CTSB and Lung
 Brain Antibodies  >19 publications with CTSB and Brain
 Skin Antibodies  >13 publications with CTSB and Skin
 Muscle Antibodies  >12 publications with CTSB and Muscle
 Pancreas Antibodies  >9 publications with CTSB and Pancreas
 Embryonic Tissue Antibodies  >7 publications with CTSB and Embryonic Tissue
 Uterus Antibodies  >6 publications with CTSB and Uterus
 Kidney Antibodies  >5 publications with CTSB and Kidney
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