View our list of available Coronavirus (COVID-19, SARS-CoV-2, 2019-nCOV) antibodies, recombinant proteins, ELISA Kits... Options Full Datasheet Printer Friendly Datasheet Prepare for Printing Full Datasheet Printer Friendly Datasheet Prepare for Printing Have Questions? Ask Us! Request A Quote Today! Add To Compare List STO-609, inhibitor Catalog # MBS515066 Unit / Price 5 mg / $320 +1 FREE 8GB USB 25 mg / $670 +1 FREE 8GB USB 5x25 mg / $2,640 +3 FREE 8GB USB Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name STO-609, Inhibitor Full Product Name STO-609 Product Synonym Names SU-4312; 3-(4-Dimethylaminobenzylidene)-1,3-dihydroindol-2-one; DMBI; 7-oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid acetate Product Gene Name STO-609, inhibitor[Similar Products] Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP Purity/Purification >98% (TLC); NMR (Conforms) Form/Format Yellow powder CAS Number 52029-86-4 Molecular Formula C19H10N2O3 - CH3COOH Activity VEGFR; PDGFR inhibitor Reconstitution May be dissolved in DMSO (25 mg/ml) Solubilization May be dissolved in: DMSO (10 mg/ml) Preparation and Storage Store desiccated as supplied at ambient temperature for up to 2 years. Store solutions at -20 degree C for up to 3 months. Other Notes Small volumes of STO-609, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Related Product Information for STO-609, inhibitor CAMKK inhibitorPotent and selective inhibitor of VEGF receptor tyrosine kinase (Flk-1, KDR). Inhibits unactivated kinase 100-fold greater (IC50=0.04 uM) than activated kinase (IC50=4.0 uM)1. Weak inhibitor of PDGF receptor tyrosine kinase (IC50=19.4 uM)2. Inhibits endothelial cell activation and angiogenesis in a mouse model of Alzheimers disease3.Scientific Background: Selective inhibitor of Ca2+-calmodulin-dependent protein kinase kinase (Ki = 80 and 15 ng/ml for inhibition of CaM-KKalpha and CaM-KKbeta respectively). Binds to the ATP-binding site. Displays >80-fold selectivity over CaMK1, CaMK2, CaMK4, MLCK, PKC, PKA and p42 MAPK. Cell permeable. Product Categories/Family for STO-609, inhibitor Inhibitors; Biochemicals - Kinase Inhibitors Molecular Structure of STO-609, inhibitor TOP Molecular Weight 314.3 TOP Product References and Citations for STO-609, inhibitor 1. RL Kendall et al. J. Biol. Chem. 1999 274:6453 2. L Sun et al. J. Med. Chem. 1998 41:2588 3. Schultheiss et al. Angiogenesis 2006 9:59 TOP Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information. TOP