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SB 431542 kinase inhibitor

Scan QR to view Datasheet Catalog #    MBS8506256
Testing Data
Unit / Price
10 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SB 431542, Kinase Inhibitor

 Also Known As   

SB 431542

 Product Gene Name   

SB 431542 kinase inhibitor

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Purity/Purification    >99%
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 Biological Activity    SB-431542 is an inhibitor of activin receptor-like kinase (ALK)5 (the TGF-betatype I receptor) (IC50 = 94 nM). It inhibits ALK5, ALK4 and ALK7. It has no effect on the other, more divergent ALK family members that recognize bone morphogenetic proteins (BMPs). SB-431542 has no effect on components of the ERK, JNK, or p38 MAP kinase pathways or on components of the signaling. [1]
 Solubility    DMSO >=77 mg/mL
Water < 1mg/ml
Ethanol >=45mg/ml
 Formula    C22H16N4O3
    
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 Preparation and Storage    At -20 degree C 2 years
 Other Notes    Small volumes of SB 431542 kinase inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for SB 431542 kinase inhibitor    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
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 Testing Data of SB 431542 kinase inhibitor    SB 431542 kinase inhibitor Testing Data image
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 Molecular Weight    384.39
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Product References and Citations for SB 431542 kinase inhibitor

   SB-431542 Is a Potent and Specific Inhibitor of Transforming Growth Factor- Superfamily Type I Activin Receptor-Like Kinase (ALK) Receptors ALK4, ALK5, and ALK7 GARETH J. INMAN, FRANCISCO J. NICOLAS,et al. Mol Pharmacol 2002;62:65 -74
The pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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