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ANXA5 kit :: ANNEXIN V KIT

Scan QR to view Datasheet Catalog #    MBS239211
Testing Data #1
Unit / Price
100 Tests  /  $490 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ANNEXIN V KIT (ANXA5), Kit

★Popular Item★
 Also Known As   

ANNEXIN V:Biotin ASSAY KIT

 Product Gene Name   

ANXA5 kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    131230
 3D Structure    ModBase 3D Structure for P08758
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 Form/Format    Biotin
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 Reagents In The Kits    Annexin V:Biotin 1 x 0.5ml vial, Propidium Iodide 1 x 1.6ml vial at 20ug/ml, Binding buffer 1 x 50ml vial at x 4 concentrate
Note: This assay also requires streptavidin:FITC conjugate for visualisation (not supplied - see recommended useful reagents section).
Perservative Stabilisers
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 Preparation and Storage    Store at 4 degree C. DO NOT FREEZE. This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 12 months from date of despatch.
 Product Note    Our Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of ANXA5 kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for ANXA5 kit

   This test employs the property of Annexin V:Biotin to bind to the membrane phospholipid phosphatidylserine (PS) in the presence of Ca2+. PS is exposed at the cell surface during the early stages of apoptosis. Detection of PS is a very sensitive method for detecting cells entering apoptosis, at a time point considerably ahead of nuclear changes such as DNA degradation. The conjugation protocol used to prepare Annexin V:Biotin has not changed the native phospholipid binding properties of Annexin V. This protocol is designed to measure apoptosis easily and quickly in a sample of suspended cells.
 Applications Tested/Suitable for ANXA5 kit   

Flow cytometry (FC/FACS)

 Application Notes for ANXA5 kit    Flow Cytometry: Maximum Dilution: Neat
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 Testing Data #1 of ANXA5 kit    Dot-plot showing Ramos cells staining with Annexin V:FITC (MBS239205) versus Propidium Iodide resulting in three distinct populations
ANXA5 kit Testing Data #1 image
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NCBI/Uniprot data below describe general gene information for ANXA5. It may not necessarily be applicable to this product.
 NCBI GI #    4502107
 NCBI GeneID    308
 NCBI Accession #    NP_001145.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001154.3 [Other Products]
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 UniProt Primary Accession #    P08758 [Other Products]
 UniProt Secondary Accession #    Q6FHB3; Q6FI16; Q8WV69; Q9UDH9; D3DNW7 [Other Products]
 UniProt Related Accession #    P08758 [Other Products]
 Molecular Weight    35,937 Da [Similar Products]
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 NCBI Official Full Name    annexin A5
 NCBI Official Synonym Full Names    annexin A5
 NCBI Official Symbol    ANXA5 [Similar Products]
 NCBI Official Synonym Symbols   
PP4; ANX5; ENX2; RPRGL3; HEL-S-7
[Similar Products]
 NCBI Protein Information    annexin A5; CBP-I; PAP-I; VAC-alpha; anchorin CII; annexin V; annexin-5; calphobindin I; endonexin II; epididymis secretory protein Li 7; lipocortin V; placental anticoagulant protein 4; placental anticoagulant protein I; thromboplastin inhibitor; vascular anticoagulant-alpha
 UniProt Protein Name    Annexin A5
 UniProt Synonym Protein Names   
Anchorin CII; Annexin V; Annexin-5; Calphobindin I; CBP-I; Endonexin II; Lipocortin V; Placental anticoagulant protein 4; PP4; Placental anticoagulant protein I; PAP-I; Thromboplastin inhibitor; Vascular anticoagulant-alpha; VAC-alpha
 Protein Family    Annexin
 UniProt Gene Name    ANXA5 [Similar Products]
 UniProt Synonym Gene Names    ANX5; ENX2; PP4; CBP-I; PP4; PAP-I; VAC-alpha [Similar Products]
 UniProt Entry Name    ANXA5_HUMAN
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 NCBI Summary for ANXA5    The protein encoded by this gene belongs to the annexin family of calcium-dependent phospholipid binding proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin 5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. Annexin 5 has also been described as placental anticoagulant protein I, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein 4 and anchorin CII. The gene spans 29 kb containing 13 exons, and encodes a single transcript of approximately 1.6 kb and a protein product with a molecular weight of about 35 kDa. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ANXA5    ANXA5: a calcium/phospholipid-binding protein and an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. The binding of labeled ANXA5 to phosphatidylserine is used as a marker of apoptosis. Annexins are a family of structurally related proteins whose common property is calcium-dependent binding to phospholipids. There are at least ten different annexins in mammalian species. Annexins do not contain signal peptides, yet some annexins (A1, A2 and A5) appear to be secreted in a physiologically regulated fashion.

Protein type: Inhibitor; Apoptosis; Lipid-binding; Calcium-binding

Chromosomal Location of Human Ortholog: 4q27

Cellular Component: focal adhesion; membrane; cytoplasm; intracellular; external side of plasma membrane

Molecular Function: phospholipase inhibitor activity; calcium-dependent phospholipid binding; phospholipid binding; calcium ion binding

Biological Process: response to organic substance; negative regulation of catalytic activity; signal transduction; blood coagulation; negative regulation of coagulation; negative regulation of apoptosis

Disease: Pregnancy Loss, Recurrent, Susceptibility To, 3
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 Research Articles on ANXA5    1. The annexin 5 in serums of pregnant women and patients with particular types of cancer
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ANXA5 kitPathways associated with ANXA5 kit
 Reference Product  PubMed Publications
 CASP3 kit  >634 publications with ANXA5 and CASP3
 S100B kit  >5 publications with ANXA5 and S100B
 VIM kit  >2 publications with ANXA5 and VIM
 PKD1 kit  >1 publications with ANXA5 and PKD1
 PRL kit  >1 publications with ANXA5 and PRL
 Products by Pathway  Pathway Diagram
 Prostaglandin Synthesis And Regulation Pathway antibodies  Prostaglandin Synthesis And Regulation Pathway Diagram
Diseases associated with ANXA5 kitOrgans/Tissues associated with ANXA5 kit
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >535 publications with ANXA5 and Necrosis
 Cardiovascular Diseases Antibodies  >392 publications with ANXA5 and Cardiovascular Diseases
 Inflammation Antibodies  >249 publications with ANXA5 and Inflammation
 Disease Models, Animal Antibodies  >147 publications with ANXA5 and Disease Models, Animal
 Heart Diseases Antibodies  >143 publications with ANXA5 and Heart Diseases
 Lung Diseases Antibodies  >102 publications with ANXA5 and Lung Diseases
 Breast Neoplasms Antibodies  >100 publications with ANXA5 and Breast Neoplasms
 Liver Diseases Antibodies  >100 publications with ANXA5 and Liver Diseases
 Liver Neoplasms Antibodies  >75 publications with ANXA5 and Liver Neoplasms
 Lung Neoplasms Antibodies  >70 publications with ANXA5 and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1394 publications with ANXA5 and Blood
 Vascular Antibodies  >329 publications with ANXA5 and Vascular
 Brain Antibodies  >248 publications with ANXA5 and Brain
 Muscle Antibodies  >214 publications with ANXA5 and Muscle
 Heart Antibodies  >199 publications with ANXA5 and Heart
 Liver Antibodies  >190 publications with ANXA5 and Liver
 Lung Antibodies  >181 publications with ANXA5 and Lung
 Bone Antibodies  >171 publications with ANXA5 and Bone
 Kidney Antibodies  >135 publications with ANXA5 and Kidney
 Eye Antibodies  >113 publications with ANXA5 and Eye
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