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ALB native protein :: Albumin, Human Serum (HSA) Low B12/Low Folate Native Protein

Scan QR to view Datasheet Catalog #    MBS318400 ALB native protein
Unit / Price
1 kg  /  $5,620 +7 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Albumin, Human Serum (HSA) Low B12/Low Folate, Native Protein

★Popular Item★
 Also Known As   

HSA (Low B12/Low Folate)

 Product Synonym Names    Human Serum Albumin (HSA), Low B12 and Low Folate
 Product Gene Name   

ALB native protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 4; NC_000004.11 (74269972..74287129). Location: 4q13.3
 OMIM    103600
 3D Structure    ModBase 3D Structure for P02768
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 Host    Phoresis Plasma
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 Specificity    Albumin, Human Serum (HSA) Low B12/Low Folate
 Purity/Purification    >99.3% pure (SPE gel electrophoresis). Cohn-Oncley Cold Alcohol Procedure
 Form/Format    Purified, Lyophilized
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 Inactivation    Not applicable
 pH    6.96 (5% solution at room temperature)
 Buffer    Not applicable
 Preservative    No
 Lyophilized    Yes
 Important Note    Centrifuge before opening to ensure complete recovery of vial contents.
 Warnings    All human source materials have tested negative for HIV1, HIV2, HCV and HTLV-1 antibodies; HIV1, HIV2, HBV and HCV by NAT testing; HBsAg and HIV-1 Ag; and ALT (SGPT) by FDA approved tests. No test guarantees a product to be non-infectious. There
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 Preparation and Storage    Short term store at 2 to 8 degree C. Long term store at -20 degree C. Avoid multiple freeze/thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of ALB native protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for ALB native protein    Purified Proteins and Bioactive Peptides
 Application Notes for ALB native protein    QC Information: B-12: 33.3pg/ml (SMAC)
Folate: BDL ng/ml (SMAC)
Biobuden (5%): <100 cfu/ml by Pour Plate at 30-35 degree C after 48 hours.

Specific methodologies have not been tested using this product.
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NCBI/Uniprot data below describe general gene information for ALB. It may not necessarily be applicable to this product.
 NCBI GI #    178344
 NCBI GeneID    213
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 UniProt Primary Accession #    P02768 [Other Products]
 UniProt Secondary Accession #    O95574; P04277; Q13140; Q645G4; Q68DN5; Q6UXK4; Q86YG0; Q9P157; Q9P1I7; Q9UHS3; Q9UJZ0 [Other Products]
 UniProt Related Accession #    P02768; Q16167; Q56G89; Q8IUK7 [Other Products]
 Molecular Weight    69,367 Da [Similar Products]
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 NCBI Official Full Name    albumin
 NCBI Official Synonym Full Names    albumin
 NCBI Official Symbol    ALB [Similar Products]
 NCBI Official Synonym Symbols   
PRO0883; PRO0903; PRO1341; DKFZp779N1935
[Similar Products]
 NCBI Protein Information    serum albumin; OTTHUMP00000160370; OTTHUMP00000196832; OTTHUMP00000220435; OTTHUMP00000220436; OTTHUMP00000220438; OTTHUMP00000220439; growth-inhibiting protein 20; cell growth inhibiting protein 42
 UniProt Protein Name    Serum albumin
 Protein Family    Serum albumin
 UniProt Gene Name    ALB [Similar Products]
 UniProt Entry Name    ALBU_HUMAN
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 NCBI Summary for ALB    Albumin is a soluble, monomeric protein which comprises about one-half of the blood serum protein. Albumin functions primarily as a carrier protein for steroids, fatty acids, and thyroid hormones and plays a role in stabilizing extracellular fluid volume. Albumin is a globular unglycosylated serum protein of molecular weight 65,000. Albumin is synthesized in the liver as preproalbumin which has an N-terminal peptide that is removed before the nascent protein is released from the rough endoplasmic reticulum. The product, proalbumin, is in turn cleaved in the Golgi vesicles to produce the secreted albumin. [provided by RefSeq]
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 UniProt Comments for ALB    Function: Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca2+, Na+, K+, fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc. Ref.33

Subcellular location: Secreted.

Tissue specificity: Plasma. Ref.35

Post-translational modification: Kenitra variant is partially O-glycosylated at Thr-620. It has two new disulfide bonds Cys-600 to Cys-602 and Cys-601 to Cys-606.Glycated in diabetic patients.Phosphorylation sites are present in the extracelllular medium.Acetylated on Lys-223 by acetylsalicylic acid.

Polymorphism: A variant structure of albumin could lead to increased binding of zinc resulting in an asymptomatic augmentation of zinc concentration in the blood. The sequence shown is that of variant albumin A.

Involvement in disease: Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [

MIM:103600]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T4. It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population. Ref.64 Ref.65 Ref.66 Ref.67

Sequence similarities: Belongs to the ALB/AFP/VDB family.Contains 3 albumin domains.

Caution: A peptide arising from positions 166 to 174 was originally (Ref.23 and Ref.24) termed neurotensin-related peptide (NRP) or kinetensin and was thought to regulates fat digestion, lipid absorption, and blood flow.

Sequence caution: The sequence AAF22034.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAF69644.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAG35503.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
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 Research Articles on ALB    1. Lower albumin levels in African Americans indicate poorer nutritional status at colorectal cancer diagnosis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ALB native proteinPathways associated with ALB native protein
 Reference Product  PubMed Publications
 APOE native protein  >3 publications with ALB and APOE
 HNF1A native protein  >2 publications with ALB and HNF1A
 AGA native protein  >2 publications with ALB and AGA
 RBP4 native protein  >1 publications with ALB and RBP4
 Products by Pathway  Pathway Diagram
 Bile Acid And Bile Salt Metabolism Pathway antibodies  Bile Acid And Bile Salt Metabolism Pathway Diagram
 FOXA2 And FOXA3 Transcription Factor Networks Pathway antibodies  FOXA2 And FOXA3 Transcription Factor Networks Pathway Diagram
 Formation Of Platelet Plug Pathway antibodies  Formation Of Platelet Plug Pathway Diagram
 HDL-mediated Lipid Transport Pathway antibodies  HDL-mediated Lipid Transport Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Lipid Digestion, Mobilization, And Transport Pathway antibodies  Lipid Digestion, Mobilization, And Transport Pathway Diagram
 Lipoprotein Metabolism Pathway antibodies  Lipoprotein Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Platelet Activation Pathway antibodies  Platelet Activation Pathway Diagram
 Platelet Degranulation Pathway antibodies  Platelet Degranulation Pathway Diagram
Diseases associated with ALB native proteinOrgans/Tissues associated with ALB native protein
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >320 publications with ALB and Liver Diseases
 Urologic Diseases Antibodies  >263 publications with ALB and Urologic Diseases
 Neoplasms Antibodies  >237 publications with ALB and Neoplasms
 Kidney Diseases Antibodies  >210 publications with ALB and Kidney Diseases
 Proteinuria Antibodies  >157 publications with ALB and Proteinuria
 Cardiovascular Diseases Antibodies  >141 publications with ALB and Cardiovascular Diseases
 Hepatitis Antibodies  >136 publications with ALB and Hepatitis
 Inflammation Antibodies  >126 publications with ALB and Inflammation
 Liver Neoplasms Antibodies  >118 publications with ALB and Liver Neoplasms
 Carcinoma Antibodies  >117 publications with ALB and Carcinoma
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1074 publications with ALB and Blood
 Liver Antibodies  >568 publications with ALB and Liver
 Kidney Antibodies  >274 publications with ALB and Kidney
 Brain Antibodies  >113 publications with ALB and Brain
 Lung Antibodies  >112 publications with ALB and Lung
 Muscle Antibodies  >88 publications with ALB and Muscle
 Heart Antibodies  >85 publications with ALB and Heart
 Spleen Antibodies  >41 publications with ALB and Spleen
 Embryonic Tissue Antibodies  >38 publications with ALB and Embryonic Tissue
 Intestine Antibodies  >25 publications with ALB and Intestine
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