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AGT native protein :: Angiotensin Native Protein

Scan QR to view Datasheet Catalog #    MBS142424 AGT native protein
Unit / Price
1 mg  /  $205 +1 FREE 8GB USB
10 mg  /  $505 +1 FREE 8GB USB
200 mg  /  $1,995 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Angiotensin (AGT), Native Protein

★Popular Item★
 Also Known As   

Angiotensin

 Product Synonym Names    Angiotensin; Angiotensin; Angiotensinogen; Serpin A8; ANHU; SERPINA8; Angiotensin
 Product Gene Name   

AGT native protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    Asn-Arg-Va l-Tyr-Val- His-Pro-Ph e-OH
 OMIM    106150
 3D Structure    ModBase 3D Structure for P01019
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 Host    Synthetic
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 Purity/Purification    Greater than 98.0% as determined by RP-HPLC.
 Form/Format    Sterile Filtered white lyophilized powder.
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 Solubility    It is recommended to reconstitute the lyophilized Angiotensin in sterile 18M Omega -cm H2O not less than 100 ug/ml or more than 10 mg/ml solutions.
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 Preparation and Storage    Lyophilized Angiotensin although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution Serpin A8 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.Please prevent freeze-thaw cycles.
 Other Notes    Small volumes of AGT native protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for AGT native protein

   Description: Angiotensin contains a total of 8 amino acids having a molecular weight of 1031.2 Dalton and a molecular formula of C49H70N14O11.

Introduction: Angiotensin is an oligopeptide in the blood that causes vasoconstriction, increased blood pressure, and release of aldosterone from the adrenal cortex. It is a powerful dipsogen. It is derived from the precursor molecule angiotensinogen, a serum globulin produced in the liver. It plays an important role in the renin-angiotensin system.The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia.
 Product Categories/Family for AGT native protein    ENZYMES; Enzymes; Natural Enzymes
NCBI/Uniprot data below describe general gene information for AGT. It may not necessarily be applicable to this product.
 NCBI GI #    4557287
 NCBI GeneID    183
 NCBI Accession #    NP_000020.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000029.3 [Other Products]
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 UniProt Primary Accession #    P01019 [Other Products]
 UniProt Secondary Accession #    Q16358; Q16359; Q96F91 [Other Products]
 UniProt Related Accession #    P01019 [Other Products]
 Molecular Weight    53,154 Da [Similar Products]
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 NCBI Official Full Name    angiotensinogen preproprotein
 NCBI Official Synonym Full Names    angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
 NCBI Official Symbol    AGT [Similar Products]
 NCBI Official Synonym Symbols   
ANHU; SERPINA8
[Similar Products]
 NCBI Protein Information    angiotensinogen; alpha-1 antiproteinase, antitrypsin; angiotensin I; angiotensin II; pre-angiotensinogen; serine (or cysteine) proteinase inhibitor; serpin A8
 UniProt Protein Name    Angiotensinogen
 UniProt Synonym Protein Names   
Serpin A8Cleaved into the following 8 chains:Angiotensin-1Alternative name(s):Angiotensin 1-10; Angiotensin I; Ang I
 Protein Family    Angiotensin
 UniProt Gene Name    AGT [Similar Products]
 UniProt Synonym Gene Names    SERPINA8; Ang I; Ang II; Ang III; Ang IV [Similar Products]
 UniProt Entry Name    ANGT_HUMAN
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 NCBI Summary for AGT    The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease. [provided by RefSeq, Jul 2008]
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 UniProt Comments for AGT    angiotensin: Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. In response to lowered blood pressure, the enzyme renin cleaves angiotensinogen to produce angiotensin-1 (angiotensin 1-10). Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin-2 (angiotensin 1- 8). Angiotensin-1 and angiotensin-2 can be further processed to generate angiotensin-3 (angiotensin 2-8), angiotensin-4 (angiotensin 3-8). Angiotensin 1-7 is cleaved from angiotensin-2 by ACE2 or from angiotensin-1 by MME (neprilysin). Angiotensin 1-9 is cleaved from angiotensin-1 by ACE2. Genetic variations in AGT are a cause of susceptibility to essential hypertension (EHT). Essential hypertension is a condition in which blood pressure is consistently higher than normal with no identifiable cause. Defects in AGT are a cause of renal tubular dysgenesis (RTD). RTD is an autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype). Belongs to the serpin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1q42.2

Cellular Component: extracellular space; cytoplasm; extracellular region

Molecular Function: serine-type endopeptidase inhibitor activity; protein binding; growth factor activity; sodium channel regulator activity; hormone activity; type 2 angiotensin receptor binding; superoxide-generating NADPH oxidase activator activity; type 1 angiotensin receptor binding

Biological Process: renal system process; extracellular matrix organization and biogenesis; positive regulation of nitric oxide biosynthetic process; establishment of blood-nerve barrier; negative regulation of nerve growth factor receptor signaling pathway; positive regulation of transcription, DNA-dependent; stress-activated MAPK cascade; female pregnancy; positive regulation of multicellular organism growth; positive regulation of vasodilation; ovarian follicle rupture; activation of NF-kappaB transcription factor; positive regulation of fibroblast proliferation; cell-cell signaling; positive regulation of superoxide release; negative regulation of neuron apoptosis; kidney development; positive regulation of NAD(P)H oxidase activity; positive regulation of cytokine production; angiotensin mediated regulation of renal output; regulation of calcium ion transport; response to muscle activity involved in regulation of muscle adaptation; regulation of norepinephrine secretion; positive regulation of phosphoinositide 3-kinase cascade; negative regulation of tissue remodeling; positive regulation of peptidyl-tyrosine phosphorylation; angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure; phospholipase C activation; regulation of transmission of nerve impulse; regulation of vasoconstriction; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); smooth muscle cell differentiation; cytokine secretion; nitric oxide mediated signal transduction; regulation of long-term neuronal synaptic plasticity; peristalsis; cell-matrix adhesion; positive regulation of cellular protein metabolic process; renin-angiotensin regulation of aldosterone production; smooth muscle cell proliferation; cellular lipid metabolic process; excretion; angiotensin maturation; vasodilation; response to salt stress; negative regulation of cell proliferation; fibroblast proliferation; positive regulation of MAPKKK cascade; renin-angiotensin regulation of blood vessel size; regulation of blood pressure; positive regulation of epidermal growth factor receptor signaling pathway; renin-angiotensin regulation of blood volume; regulation of cell growth; angiotensin mediated drinking behavior; artery smooth muscle contraction; aging; blood vessel development; positive regulation of fatty acid biosynthetic process; cellular sodium ion homeostasis; renal response to blood flow during renin-angiotensin regulation of systemic arterial blood pressure; activation of NF-kappaB-inducing kinase; positive regulation of organ growth; positive regulation of peptidyl-serine phosphorylation; regulation of cell proliferation; G-protein coupled receptor protein signaling pathway; negative regulation of angiogenesis; cellular protein metabolic process; ureteric bud branching; blood vessel remodeling; G-protein signaling, coupled to cGMP nucleotide second messenger; response to cold; negative regulation of cell growth; astrocyte activation; positive regulation of inflammatory response

Disease: Renal Tubular Dysgenesis; Hypertension, Essential
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 Research Articles on AGT    1. This study indicates that miR-34a plays a role in regulation of Ang II-induced cardiomyocyte hypertrophy by inhibition of ATG9A expression and autophagic activity.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with AGT native proteinPathways associated with AGT native protein
 Reference Product  PubMed Publications
 ACE native protein  >461 publications with AGT and ACE
 AGTR1 native protein  >112 publications with AGT and AGTR1
 REN native protein  >60 publications with AGT and REN
 AGTR2 native protein  >58 publications with AGT and AGTR2
 ACE2 native protein  >29 publications with AGT and ACE2
 TGFB1 native protein  >25 publications with AGT and TGFB1
 IL6 native protein  >7 publications with AGT and IL6
 INS native protein  >5 publications with AGT and INS
 Products by Pathway  Pathway Diagram
 ACE Inhibitor Pathway antibodies  ACE Inhibitor Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
Diseases associated with AGT native proteinOrgans/Tissues associated with AGT native protein
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >588 publications with AGT and Cardiovascular Diseases
 Hypertension Antibodies  >559 publications with AGT and Hypertension
 Kidney Diseases Antibodies  >284 publications with AGT and Kidney Diseases
 Heart Diseases Antibodies  >179 publications with AGT and Heart Diseases
 Hypertension, Renal Antibodies  >133 publications with AGT and Hypertension, Renal
 Myocardial Ischemia Antibodies  >105 publications with AGT and Myocardial Ischemia
 Hypertrophy Antibodies  >78 publications with AGT and Hypertrophy
 Atherosclerosis Antibodies  >71 publications with AGT and Atherosclerosis
 Proteinuria Antibodies  >69 publications with AGT and Proteinuria
 Myocardial Infarction Antibodies  >65 publications with AGT and Myocardial Infarction
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >736 publications with AGT and Blood
 Kidney Antibodies  >329 publications with AGT and Kidney
 Liver Antibodies  >292 publications with AGT and Liver
 Heart Antibodies  >169 publications with AGT and Heart
 Brain Antibodies  >127 publications with AGT and Brain
 Lung Antibodies  >79 publications with AGT and Lung
 Muscle Antibodies  >75 publications with AGT and Muscle
 Bone Antibodies  >65 publications with AGT and Bone
 Connective Tissue Antibodies  >54 publications with AGT and Connective Tissue
 Ovary Antibodies  >43 publications with AGT and Ovary
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