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SERPINC1 native protein :: Antithrombin III Native Protein

Scan QR to view Datasheet Catalog #    MBS318172 SERPINC1 native protein
Unit / Price
0.1 mg  /  $205 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Antithrombin III (SERPINC1), Native Protein

 Also Known As   

Human Plasma Antithrombin III

 Product Gene Name   

SERPINC1 native protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 1; NC_000001.10 (173872942..173886516, complement). Location: 1q23-q25.1
 OMIM    107300
 3D Structure    ModBase 3D Structure for P01008
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 Host    Human Plasma
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 Specificity    Antithrombin III
 Purity/Purification    >95% pure (SDS-PAGE)
 Form/Format    Purified, Lyophilized.
Reconstitute with 81.3ul distilled water.
 Concentration    1.23mg/ml (prior to lyophilization) (lot specific)
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 Inactivation    Not applicable.
 Buffer    Lyophilized from 50mM Tris-HCl, pH 8.0 containing 150mM Sodium chloride
 Preservative    No
 Lyophilized    Yes
 Warnings    All human source materials have tested negative for HIV1, HIV2 and non-reactive for HCV and HBc antibodies and HBsAg. No test guarantees a product to be non-infectious. Therefore, all material derived from human fluids or tissues should be consi
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 Preparation and Storage    Store at -20 degree C. Avoid multiple freeze/thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of SERPINC1 native protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for SERPINC1 native protein

   Antithrombin III is found in normal serum at 15mg/100ml. Found at higher levels in plasma than in serum because of complexing with thrombin during coagulation. Functions in the inhibition of the proteolytic enzymes involved in blood coagulation and fibrin
 Product Categories/Family for SERPINC1 native protein    Purified Platelets and Hemostasis Antigens
 Applications Tested/Suitable for SERPINC1 native protein   

IEP

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NCBI/Uniprot data below describe general gene information for SERPINC1. It may not necessarily be applicable to this product.
 NCBI GI #    179130
 NCBI GeneID    462
 NCBI Accession #    AAB40025.1 [Other Products]
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 UniProt Primary Accession #    P01008 [Other Products]
 UniProt Secondary Accession #    P78439; P78447; Q13815; Q5TC78; Q7KZ43; Q7KZ97; Q9UC78; B2R6P0 [Other Products]
 UniProt Related Accession #    P01008; Q7KYQ5; Q7KYY4; Q8IZZ8; Q8IZZ9; Q8J000; Q8J001; Q8TCE1; Q9UBW9; Q9UE54 [Other Products]
 Molecular Weight    52,602 Da [Similar Products]
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 NCBI Official Full Name    antithrombin III
 NCBI Official Synonym Full Names    serpin peptidase inhibitor, clade C (antithrombin), member 1
 NCBI Official Symbol    SERPINC1 [Similar Products]
 NCBI Official Synonym Symbols   
AT3; ATIII; MGC22579
[Similar Products]
 NCBI Protein Information    antithrombin-III; serpin C1; antithrombin III; OTTHUMP00000035393; serine-cysteine proteinase inhibitor clade C member 1; serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1
 UniProt Protein Name    Antithrombin-III
 UniProt Synonym Protein Names   
Serpin C1
 Protein Family    Antithrombin
 UniProt Gene Name    SERPINC1 [Similar Products]
 UniProt Synonym Gene Names    AT3 [Similar Products]
 UniProt Entry Name    ANT3_HUMAN
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 NCBI Summary for SERPINC1    The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency. [provided by RefSeq]
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 UniProt Comments for SERPINC1    Function: Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin.

Subcellular location: Secreted › extracellular space.

Tissue specificity: Found in plasma. Ref.21

Post-translational modification: Phosphorylation sites are present in the extracelllular medium.

Involvement in disease: Defects in SERPINC1 are the cause of antithrombin III deficiency (AT3D) [

MIM:613118]. AT3D is an important risk factor for hereditary thrombophilia, a hemostatic disorder characterized by a tendency to recurrent thrombosis. AT3D is classified into 4 types. Type I: characterized by a 50% decrease in antigenic and functional levels. Type II: has defects affecting the thrombin-binding domain. Type III: alteration of the heparin-binding domain. Plasma AT-III antigen levels are normal in type II and III. Type IV: consists of miscellaneous group of unclassifiable mutations. Ref.3 Ref.12 Ref.13 Ref.31 Ref.32 Ref.33 Ref.34 Ref.35 Ref.36 Ref.37 Ref.38 Ref.40 Ref.41 Ref.42 Ref.43 Ref.44 Ref.45 Ref.46 Ref.47 Ref.48 Ref.49 Ref.50 Ref.51 Ref.52 Ref.53 Ref.54 Ref.55 Ref.56 Ref.57 Ref.59 Ref.60 Ref.61 Ref.62 Ref.63 Ref.64 Ref.65 Ref.66

Sequence similarities: Belongs to the serpin family.

Mass spectrometry: Molecular mass is 57863 Da from positions 33 - 464. Determined by ESI. Ref.13Molecular mass is 57911 Da from positions 33 - 464. Determined by ESI. Variant Thr-414. Ref.13
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 Research Articles on SERPINC1    1. descriptions of and pedigrees for 2 cases of antithrombin deficiency in China: (1) frameshift mutation in SERPINC1 and (2) large deletion including all seven exons of SERPINC1
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with SERPINC1 native proteinPathways associated with SERPINC1 native protein
 Reference Product  PubMed Publications
 PLG native protein  >1 publications with SERPINC1 and PLG
 Products by Pathway  Pathway Diagram
 Common Pathway antibodies  Common Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies  Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram
 Glypican 1 Network Pathway antibodies  Glypican 1 Network Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
Diseases associated with SERPINC1 native proteinOrgans/Tissues associated with SERPINC1 native protein
 Disease Name  Pubmed Publications
 Thrombophilia Antibodies  >14 publications with SERPINC1 and Thrombophilia
 Antithrombin III Deficiency Antibodies  >12 publications with SERPINC1 and Antithrombin III Deficiency
 Vascular Diseases Antibodies  >11 publications with SERPINC1 and Vascular Diseases
 Thrombosis Antibodies  >10 publications with SERPINC1 and Thrombosis
 Venous Thrombosis Antibodies  >7 publications with SERPINC1 and Venous Thrombosis
 Lung Diseases Antibodies  >2 publications with SERPINC1 and Lung Diseases
 Liver Neoplasms Antibodies  >2 publications with SERPINC1 and Liver Neoplasms
 Adenocarcinoma Antibodies  >2 publications with SERPINC1 and Adenocarcinoma
 Hypertension Antibodies  >2 publications with SERPINC1 and Hypertension
 Neoplasms Antibodies  >2 publications with SERPINC1 and Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >4 publications with SERPINC1 and Liver
 Muscle Antibodies  >2 publications with SERPINC1 and Muscle
 Brain Antibodies  >1 publications with SERPINC1 and Brain
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