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ApoA-I native protein

Scan QR to view Datasheet Catalog #    MBS537610 ApoA-I native protein
Unit / Price
0.5 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ApoA-I, Native Protein

 Also Known As   

ApoA-I protein

 Product Synonym Names    ApoA I protein; Apo AI protein; Apolipoprotein A-I protein; ApoA1 protein
 Product Gene Name   

ApoA-I native protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q9Y355
 Host    Human
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 Purity/Purification    > 95% pure
 Form/Format    Supplied in 10mM NH4HCO3, pH 7.4.
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 Source Note    Human plasma
 Protein Type    Native
 Biological Significance    75% of Apo A in HDL is Apo AI. Levels of Apo AI are inversely related to the risk of coronary heart disease. Apo AI is also thought to activate LCAT (lecithin cholesterol acyl tranferase). In normal plasma, Apo AI levels range from 90-130 mg per 100 ml.
 Biohazard Information    Donor samples were tested and found to be negative for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2. Nonetheless caution should be used when handling this material as there is a margin of error in all tests.
 Dry Ice Shipment    Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
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 Preparation and Storage    Aliquot and store at -70 degree C or lower. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of ApoA-I native protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for ApoA-I native protein

   Purified native Human ApoA-I protein
 Product Categories/Family for ApoA-I native protein    Cardiac Markers; Native Protein
 Applications Tested/Suitable for ApoA-I native protein   

User optimized

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NCBI/Uniprot data below describe general gene information for ApoA-I. It may not necessarily be applicable to this product.
 NCBI GI #    4960066
 NCBI GeneID    335
 NCBI Accession #    AAD34604.1 [Other Products]
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 UniProt Primary Accession #    Q9Y355 [Other Products]
 UniProt Related Accession #    P02647 [Other Products]
 Molecular Weight    7,433 Da
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 NCBI Official Full Name    apolipoprotein A1, partial
 NCBI Official Synonym Full Names    apolipoprotein A-I
 NCBI Official Symbol    APOA1 [Similar Products]
 NCBI Protein Information    apolipoprotein A-I
 UniProt Protein Name    Apolipoprotein A1
 UniProt Synonym Protein Names   
Apolipoprotein A1
 UniProt Entry Name    Q9Y355_HUMAN
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 NCBI Summary for ApoA-I    This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The protein promotes cholesterol efflux from tissues to the liver for excretion, and it is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. This gene is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ApoA-I    APOA1: Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. Interacts with APOA1BP and CLU. Component of a sperm activating protein complex (SPAP), consisting of APOA1, an immunoglobulin heavy chain, an immunoglobulin light chain and albumin. Interacts with NDRG1. Major protein of plasma HDL, also found in chylomicrons. Synthesized in the liver and small intestine. The oxidized form at Met-110 and Met-136 is increased in individuals with increased risk for coronary artery disease, such as in carrier of the eNOSa/b genotype and exposure to cigarette smoking. It is also present in increased levels in aortic lesions relative to native ApoA-I and increased levels are seen with increasing severity of disease. Belongs to the apolipoprotein A1/A4/E family.

Protein type: Lipid-binding; Vesicle; Motility/polarity/chemotaxis; Secreted; Endoplasmic reticulum; Secreted, signal peptide; Cell development/differentiation

Chromosomal Location of Human Ortholog: 11q23-q24

Cellular Component: extracellular space; chylomicron; cell surface; endocytic vesicle; endoplasmic reticulum lumen; early endosome; extracellular region; plasma membrane; cytoplasmic vesicle; nucleus; cytosol; vesicle

Molecular Function: identical protein binding; protein binding; enzyme binding; phospholipid transporter activity; lipase inhibitor activity; beta-amyloid binding; cholesterol transporter activity; chemorepellent activity; cholesterol binding; phospholipid binding; phosphatidylcholine binding; high-density lipoprotein binding; apolipoprotein A-I receptor binding; apolipoprotein receptor binding

Biological Process: phototransduction, visible light; negative chemotaxis; negative regulation of lipase activity; axon regeneration in the peripheral nervous system; sequestering of lipid; negative regulation of interleukin-1 beta secretion; regulation of cholesterol absorption; transforming growth factor beta receptor signaling pathway; positive regulation of stress fiber formation; response to drug; platelet activation; cholesterol metabolic process; organ regeneration; regulation of Cdc42 protein signal transduction; adrenal gland development; positive regulation of hydrolase activity; positive regulation of Rho protein signal transduction; lipoprotein metabolic process; positive regulation of transferase activity; vitamin transport; cholesterol biosynthetic process; negative regulation of cytokine secretion during immune response; cholesterol homeostasis; response to estrogen stimulus; lipoprotein biosynthetic process; peptidyl-methionine modification; phosphatidylcholine biosynthetic process; positive regulation of lipoprotein lipase activity; blood vessel endothelial cell migration; cellular lipid metabolic process; platelet degranulation; phospholipid efflux; retinoid metabolic process; transmembrane transport; response to nutrient; phospholipid homeostasis; integrin-mediated signaling pathway; positive regulation of fatty acid biosynthetic process; receptor-mediated endocytosis; regulation of protein amino acid phosphorylation; cholesterol transport; negative regulation of heterotypic cell-cell adhesion; protein amino acid oxidation; protein stabilization; neurite regeneration; cholesterol efflux; G-protein coupled receptor protein signaling pathway; glucocorticoid metabolic process; reverse cholesterol transport; negative regulation of inflammatory response; endothelial cell proliferation; blood coagulation

Disease: Hypoalphalipoproteinemia, Primary; Amyloidosis, Familial Visceral
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 Research Articles on ApoA-I    1. apoA-I was inversely associated with the presence of cerebral white matter lesions
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ApoA-I native proteinPathways associated with ApoA-I native protein
 Reference Product  PubMed Publications
 APOB native protein  >506 publications with ApoA-I and APOB
 APOE native protein  >152 publications with ApoA-I and APOE
 ABCA1 native protein  >142 publications with ApoA-I and ABCA1
 APOC3 native protein  >74 publications with ApoA-I and APOC3
 CETP native protein  >60 publications with ApoA-I and CETP
 APOA2 native protein  >43 publications with ApoA-I and APOA2
 LCAT native protein  >41 publications with ApoA-I and LCAT
 TTR native protein  >8 publications with ApoA-I and TTR
 HNF4A native protein  >4 publications with ApoA-I and HNF4A
 FGA native protein  >3 publications with ApoA-I and FGA
 Products by Pathway  Pathway Diagram
 ABC-family Proteins Mediated Transport Pathway antibodies  ABC-family Proteins Mediated Transport Pathway Diagram
 ABCA Transporters In Lipid Homeostasis Pathway antibodies  ABCA Transporters In Lipid Homeostasis Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 Amyloids Pathway antibodies  Amyloids Pathway Diagram
 Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies  Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram
 Chylomicron-mediated Lipid Transport Pathway antibodies  Chylomicron-mediated Lipid Transport Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 FOXA2 And FOXA3 Transcription Factor Networks Pathway antibodies  FOXA2 And FOXA3 Transcription Factor Networks Pathway Diagram
 Fat Digestion And Absorption Pathway antibodies  Fat Digestion And Absorption Pathway Diagram
Organs/Tissues associated with ApoA-I native protein
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >834 publications with ApoA-I and Blood
 Liver Antibodies  >192 publications with ApoA-I and Liver
 Heart Antibodies  >165 publications with ApoA-I and Heart
 Muscle Antibodies  >37 publications with ApoA-I and Muscle
 Brain Antibodies  >35 publications with ApoA-I and Brain
 Lung Antibodies  >22 publications with ApoA-I and Lung
 Intestine Antibodies  >16 publications with ApoA-I and Intestine
 Ovary Antibodies  >15 publications with ApoA-I and Ovary
 Pancreas Antibodies  >7 publications with ApoA-I and Pancreas
 Embryonic Tissue Antibodies  >4 publications with ApoA-I and Embryonic Tissue
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