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ApoE native protein

Scan QR to view Datasheet Catalog #    MBS537055 ApoE native protein
Unit / Price
0.1 mg  /  $460 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ApoE, Native Protein

 Also Known As   

ApoE protein

 Product Synonym Names    VLDL protein; APO E protein; Apolipoprotein E protein; Apo-E protein; Very Low Density Lipoprotein protein
 Product Gene Name   

ApoE native protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    104310
 3D Structure    ModBase 3D Structure for P02649
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 Host    Human
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 Purity/Purification    > 95% pure
 Form/Format    Supplied in 50mM NH4HCO3, pH 8.0.
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 Source Note    Human plasma
 Protein Type    Native
 Biological Significance    Apolipoprotein E serves as a ligand for low density receptors and participates in the transport and redistribution of cholesterol and other lipids. Other functions include immunoregulation and cell growth modulation and differentiation. Apo E is thought to be involved in tissue repair as increased amounts of the protein are found at sites of peripheral nerve injury and regeneration. A mutant form is associated with familial type III hyperlipoproteinemia.
 Biohazard Information    Donor samples were tested and found to be negative for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2. Nonetheless caution should be used when handling this material as there is a margin of error in all tests.
 Dry Ice Shipment    Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
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 Preparation and Storage    Aliquot and store at -70 degree C or lower. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of ApoE native protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for ApoE native protein

   Purified native Human ApoE protein
 Product Categories/Family for ApoE native protein    Neuroscience; Native Protein
 Applications Tested/Suitable for ApoE native protein   

User optimized

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NCBI/Uniprot data below describe general gene information for ApoE. It may not necessarily be applicable to this product.
 NCBI GI #    4557325
 NCBI GeneID    348
 NCBI Accession #    NP_000032.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000041.2 [Other Products]
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 UniProt Primary Accession #    P02649 [Other Products]
 UniProt Secondary Accession #    Q9P2S4; B2RC15; C0JYY5 [Other Products]
 UniProt Related Accession #    P02649 [Other Products]
 Molecular Weight    34 kDa
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 NCBI Official Full Name    apolipoprotein E isoform b
 NCBI Official Synonym Full Names    apolipoprotein E
 NCBI Official Symbol    APOE [Similar Products]
 NCBI Official Synonym Symbols   
AD2; LPG; APO-E; LDLCQ5
[Similar Products]
 NCBI Protein Information    apolipoprotein E
 UniProt Protein Name    Apolipoprotein E
 Protein Family    Apolipoprotein
 UniProt Gene Name    APOE [Similar Products]
 UniProt Synonym Gene Names    Apo-E [Similar Products]
 UniProt Entry Name    APOE_HUMAN
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 NCBI Summary for ApoE    The protein encoded by this gene is a major apoprotein of the chylomicron. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. This gene maps to chromosome 19 in a cluster with the related apolipoprotein C1 and C2 genes. Mutations in this gene result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
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 UniProt Comments for ApoE    APOE: Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues. Defects in APOE are a cause of hyperlipoproteinemia type 3 (HLPP3); also known as familial dysbetalipoproteinemia. Individuals with HLPP3 are clinically characterized by xanthomas, yellowish lipid deposits in the palmar crease, or less specific on tendons and on elbows. The disorder rarely manifests before the third decade in men. In women, it is usually expressed only after the menopause. The vast majority of the patients are homozygous for APOE*2 alleles. More severe cases of HLPP3 have also been observed in individuals heterozygous for rare APOE variants. The influence of APOE on lipid levels is often suggested to have major implications for the risk of coronary artery disease (CAD). Individuals carrying the common APOE*4 variant are at higher risk of CAD. Genetic variations in APOE are associated with Alzheimer disease type 2 (AD2). It is a late-onset neurodegenerative disorder characterized by progressive dementia, loss of cognitive abilities, and deposition of fibrillar amyloid proteins as intraneuronal neurofibrillary tangles, extracellular amyloid plaques and vascular amyloid deposits. The major constituent of these plaques is the neurotoxic amyloid-beta-APP 40-42 peptide (s), derived proteolytically from the transmembrane precursor protein APP by sequential secretase processing. The cytotoxic C-terminal fragments (CTFs) and the caspase-cleaved products such as C31 derived from APP, are also implicated in neuronal death. The APOE*4 allele is genetically associated with the common late onset familial and sporadic forms of Alzheimer disease. Risk for AD increased from 20% to 90% and mean age at onset decreased from 84 to 68 years with increasing number of APOE*4 alleles in 42 families with late onset AD. Thus APOE*4 gene dose is a major risk factor for late onset AD and, in these families, homozygosity for APOE*4 was virtually sufficient to cause AD by age 80. The mechanism by which APOE*4 participates in pathogenesis is not known. Defects in APOE are a cause of sea-blue histiocyte disease (SBHD); also known as sea-blue histiocytosis. This disorder is characterized by splenomegaly, mild thrombocytopenia and, in the bone marrow, numerous histiocytes containing cytoplasmic granules which stain bright blue with the usual hematologic stains. The syndrome is the consequence of an inherited metabolic defect analogous to Gaucher disease and other sphingolipidoses. Defects in APOE are a cause of lipoprotein glomerulopathy (LPG). LPG is an uncommon kidney disease characterized by proteinuria, progressive kidney failure, and distinctive lipoprotein thrombi in glomerular capillaries. It mainly affects people of Japanese and Chinese origin. The disorder has rarely been described in Caucasians. Belongs to the apolipoprotein A1/A4/E family.

Protein type: Secreted, signal peptide; Secreted; Lipid-binding

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: Golgi apparatus; microtubule; extracellular space; lysosome; endoplasmic reticulum; dendrite; early endosome; extracellular region; nuclear envelope; extracellular matrix; chylomicron; extrinsic to external side of plasma membrane; membrane; cell soma; late endosome; cytoplasm; plasma membrane; nucleus; vesicle

Molecular Function: heparin binding; lipid transporter activity; identical protein binding; protein homodimerization activity; metal chelating activity; beta-amyloid binding; cholesterol binding; antioxidant activity; protein binding; low-density lipoprotein receptor binding; cholesterol transporter activity; hydroxyapatite binding; phospholipid binding; lipid binding; tau protein binding

Biological Process: phototransduction, visible light; lipoprotein catabolic process; negative regulation of MAP kinase activity; cGMP-mediated signaling; positive regulation of axon extension; axon regeneration in the peripheral nervous system; positive regulation of membrane protein ectodomain proteolysis; synaptic transmission, cholinergic; intracellular transport; triacylglycerol catabolic process; oligodendrocyte differentiation; negative regulation of neuron apoptosis; cholesterol catabolic process; long-chain fatty acid transport; cholesterol metabolic process; regulation of Cdc42 protein signal transduction; positive regulation of nitric-oxide synthase activity; negative regulation of blood coagulation; lipoprotein metabolic process; positive regulation of lipid biosynthetic process; regulation of axon extension; negative regulation of blood vessel endothelial cell migration; maintenance of cellular localization; cholesterol homeostasis; response to reactive oxygen species; response to ethanol; positive regulation of cGMP biosynthetic process; lipoprotein biosynthetic process; regulation of gene expression; negative regulation of endothelial cell proliferation; protein import; nitric oxide mediated signal transduction; regulation of neuronal synaptic plasticity; response to dietary excess; vasodilation; response to insulin stimulus; positive regulation of low-density lipoprotein receptor catabolic process; phospholipid efflux; negative regulation of cholesterol biosynthetic process; retinoid metabolic process; aging; receptor-mediated endocytosis; response to retinoic acid; negative regulation of lipid biosynthetic process; neurite regeneration; cholesterol efflux; cytoskeleton organization and biogenesis; cellular calcium ion homeostasis; G-protein coupled receptor protein signaling pathway; triacylglycerol metabolic process; reverse cholesterol transport; negative regulation of inflammatory response; fatty acid homeostasis; artery morphogenesis

Disease: Macular Degeneration, Age-related, 1; Alzheimer Disease 2; Alzheimer Disease 4; Lipoprotein Glomerulopathy; Sea-blue Histiocyte Disease
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 Research Articles on ApoE    1. Lipid profiles were not increased after Paliperidone treatment under the control of ApoE gene polymorphism.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ApoE native proteinPathways associated with ApoE native protein
 Reference Product  PubMed Publications
 APOB native protein  >1491 publications with ApoE and APOB
 LDLR native protein  >566 publications with ApoE and LDLR
 LPL native protein  >327 publications with ApoE and LPL
 APOA1 native protein  >152 publications with ApoE and APOA1
 LRP1 native protein  >79 publications with ApoE and LRP1
 APOC3 native protein  >78 publications with ApoE and APOC3
 APOA2 native protein  >20 publications with ApoE and APOA2
 LRP8 native protein  >16 publications with ApoE and LRP8
 HSPG2 native protein  >7 publications with ApoE and HSPG2
 LRP2 native protein  >5 publications with ApoE and LRP2
 Products by Pathway  Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies  Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram
 Chylomicron-mediated Lipid Transport Pathway antibodies  Chylomicron-mediated Lipid Transport Pathway Diagram
 HDL-mediated Lipid Transport Pathway antibodies  HDL-mediated Lipid Transport Pathway Diagram
 Lipid Digestion, Mobilization, And Transport Pathway antibodies  Lipid Digestion, Mobilization, And Transport Pathway Diagram
 Lipoprotein Metabolism Pathway antibodies  Lipoprotein Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
Diseases associated with ApoE native proteinOrgans/Tissues associated with ApoE native protein
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >6223 publications with ApoE and Cardiovascular Diseases
 Alzheimer Disease Antibodies  >5743 publications with ApoE and Alzheimer Disease
 Atherosclerosis Antibodies  >4983 publications with ApoE and Atherosclerosis
 Arteriosclerosis Antibodies  >4098 publications with ApoE and Arteriosclerosis
 Hyperlipidemias Antibodies  >1842 publications with ApoE and Hyperlipidemias
 Inflammation Antibodies  >1695 publications with ApoE and Inflammation
 Cognition Disorders Antibodies  >1413 publications with ApoE and Cognition Disorders
 Plaque, Atherosclerotic Antibodies  >1304 publications with ApoE and Plaque, Atherosclerotic
 Coronary Disease Antibodies  >1149 publications with ApoE and Coronary Disease
 Hypercholesterolemia Antibodies  >1055 publications with ApoE and Hypercholesterolemia
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >4459 publications with ApoE and Brain
 Vascular Antibodies  >4211 publications with ApoE and Vascular
 Liver Antibodies  >1907 publications with ApoE and Liver
 Heart Antibodies  >1631 publications with ApoE and Heart
 Muscle Antibodies  >1221 publications with ApoE and Muscle
 Nerve Antibodies  >640 publications with ApoE and Nerve
 Bone Antibodies  >599 publications with ApoE and Bone
 Kidney Antibodies  >515 publications with ApoE and Kidney
 Lung Antibodies  >287 publications with ApoE and Lung
 Spleen Antibodies  >247 publications with ApoE and Spleen
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