NM_005577.2
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
apolipoprotein(a)
NCBI Official Synonym Full Names
lipoprotein(a)
NCBI Protein Information
apolipoprotein(a)
UniProt Protein Name
Apolipoprotein(a)
UniProt Synonym Gene Names
UniProt Entry Name
APOA_HUMAN
NCBI Summary for Apo A
The protein encoded by this gene is a serine proteinase that inhibits the activity of tissue-type plasminogen activator I. The encoded protein constitutes a substantial portion of lipoprotein(a) and is proteolytically cleaved, resulting in fragments that attach to atherosclerotic lesions and promote thrombogenesis. Elevated plasma levels of this protein are linked to atherosclerosis. Depending on the individual, the encoded protein contains 2-43 copies of kringle-type domains. The allele represented here contains 15 copies of the kringle-type repeats and corresponds to that found in the reference genome sequence. [provided by RefSeq, Dec 2009]
UniProt Comments for Apo A
Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp(a) may be a ligand for megalin/Gp 330.
Product References and Citations for Apo A native protein
Saito H, Lund-Katz S, Phillips MC (July 2004). "Contributions of domain structure and lipid interaction to the functionality of exchangeable human apolipoproteins". Prog. Lipid Res. 43 (4): 350-80. Wilson C, Wardell MR, Weisgraber KH, Mahley RW, Agard DA; Wardell; Weisgraber; Mahley; Agard (June 1991). "Three-dimensional structure of the LDL receptor-binding domain of human apolipoprotein E". Science 252 (5014): 1817-22.
Research Articles on Apo A
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Products associated with Apo A native protein
Pathways associated with Apo A native protein
Organs/Tissues associated with Apo A native protein
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