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APOA2 native protein :: Apolipoprotein AII (Apo AII) Native Protein

Scan QR to view Datasheet Catalog #    MBS318206 APOA2 native protein
Unit / Price
0.5 mg  /  $245 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Apolipoprotein AII (Apo AII) (APOA2), Native Protein

★Popular Item★
 Also Known As   

Human Apolipoprotein AII (Apo-AII)

 Product Gene Name   

APOA2 native protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 1; NC_000001.10 (161192083..161193418, complement). Location: 1q21-q23
 OMIM    107670
 3D Structure    ModBase 3D Structure for P02652
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 Host    Human Plasma, High Density Lipoprotein
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 Specificity    Apolipoprotein AII (Apo AII)
 Purity/Purification    >95% pure (SDS-PAGE). Single band on polyacrylamide electrophoresis
 Form/Format    Purified, Liquid
 Concentration    1.63 mg/ml (lot specific)
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 Note    Centrifuge before opening to ensure complete recovery of vial contents
 Inactivation    Not applicable
 Buffer    10mM Ammonium Bicarbonate, pH 7.4
 Preservative    No
 Dry Ice Shipment    Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
 Warnings    All human source materials have tested negative for anti-HIV 1 and anti-HIV 2, and non-reactive for anti-HCV and anti-HBc antibodies and HBsAg. No test guarantees a product to be non-infectious. Therefore, all material derived from human fluids or tissues should be considered as potentially infectious.
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 Preparation and Storage    Store at < = -70 degree C. Keep concentration > = 1mg/ml as precipitation may occur below 1mg/ml. Avoid multiple freeze/thaw cycles.
Shipping: ships on Dry Ice
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of APOA2 native protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for APOA2 native protein

   Human Apolipoprotein AII (Apo-AII)
 Product Categories/Family for APOA2 native protein    Purified Lipoproteins
 Applications Tested/Suitable for APOA2 native protein   

Specific methodologies have not been tested using this product

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NCBI/Uniprot data below describe general gene information for APOA2. It may not necessarily be applicable to this product.
 NCBI GI #    114000
 NCBI GeneID    336
 NCBI Accession #    P02652.1 [Other Products]
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 UniProt Primary Accession #    P02652 [Other Products]
 UniProt Secondary Accession #    B2R524 [Other Products]
 UniProt Related Accession #    P02652; Q76EI7 [Other Products]
 Molecular Weight    11,175 Da [Similar Products]
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 NCBI Official Full Name    Apolipoprotein A-II
 NCBI Official Synonym Full Names    apolipoprotein A-II
 NCBI Official Symbol    APOA2 [Similar Products]
 NCBI Official Synonym Symbols   
apoAII; Apo-AII; ApoA-II
[Similar Products]
 NCBI Protein Information    apolipoprotein A-II; apolipoprotein A2; OTTHUMP00000032244
 UniProt Protein Name    Apolipoprotein A-II
 UniProt Synonym Protein Names   
Apolipoprotein A2
 Protein Family    Apolipoprotein
 UniProt Gene Name    APOA2 [Similar Products]
 UniProt Entry Name    APOA2_HUMAN
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 NCBI Summary for APOA2    This gene encodes apolipoprotein (apo-) A-II, which is the second most abundant protein of the high density lipoprotein particles. The protein is found in plasma as a monomer, homodimer, or heterodimer with apolipoprotein D. Defects in this gene may result in apolipoprotein A-II deficiency or hypercholesterolemia. [provided by RefSeq]
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 UniProt Comments for APOA2    Function: May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism.

Subunit structure: Homodimer; disulfide-linked. Also forms a disulfide-linked heterodimer with APOD. Interacts with HCV core protein. Interacts with APOA1BP. Ref.14 Ref.15 Ref.18

Subcellular location: Secreted.

Tissue specificity: Plasma; synthesized in the liver and intestine.

Post-translational modification: Phosphorylation sites are present in the extracelllular medium.

Sequence similarities: Belongs to the apolipoprotein A2 family.

Mass spectrometry: Molecular mass is 8701.2 Da from positions 24 - 100. Determined by MALDI. Ref.16Molecular mass is 8823.4 Da from positions 24 - 100. Determined by MALDI. Cysteinylated ApoA-II. Ref.16Molecular mass is 17421.3 Da from positions 24 - 100. Determined by MALDI. Homodimer. Ref.16Molecular mass is 17293.4 Da from positions 24 - 100. Determined by MALDI. Heterodimer with apolipoprotein A-II(1-76). Ref.16Molecular mass is 8578.3 Da from positions 24 - 99. Determined by MALDI. Ref.16Molecular mass is 17166.2 Da from positions 24 - 99. Determined by MALDI. Homodimer. Ref.16
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Product References and Citations for APOA2 native protein

   • Malik, Gunjan., et al., (2005), "Serum Levels of an Isoform of Apolipoprotein AII as a Potential Marker for Prostate Cancer", Clinical Cancer Research, 11, 1073-1085
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 Research Articles on APOA2    1. Human apolipoprotein A-II inhibits the production of interferon-gamma by concanavalin A-stimulated mouse and human CD4-positive T cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with APOA2 native proteinPathways associated with APOA2 native protein
 Reference Product  PubMed Publications
 APOC1 native protein  >1 publications with APOA2 and APOC1
 Products by Pathway  Pathway Diagram
 Chylomicron-mediated Lipid Transport Pathway antibodies  Chylomicron-mediated Lipid Transport Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 Lipid Digestion, Mobilization, And Transport Pathway antibodies  Lipid Digestion, Mobilization, And Transport Pathway Diagram
 Lipoprotein Metabolism Pathway antibodies  Lipoprotein Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 PPAR Signaling Pathway antibodies  PPAR Signaling Pathway Diagram
 PPAR Signaling Pathway antibodies  PPAR Signaling Pathway Diagram
 Regulation Of Lipid Metabolism By Peroxisome Proliferator-activated Receptor Alpha (PPARalpha) Pathway antibodies  Regulation Of Lipid Metabolism By Peroxisome Proliferator-activated Receptor Alpha (PPARalpha) Pathway Diagram
 Statin Pathway antibodies  Statin Pathway Diagram
Diseases associated with APOA2 native proteinOrgans/Tissues associated with APOA2 native protein
 Disease Name  Pubmed Publications
 Dyslipidemias Antibodies  >14 publications with APOA2 and Dyslipidemias
 Obesity Antibodies  >13 publications with APOA2 and Obesity
 Vascular Diseases Antibodies  >12 publications with APOA2 and Vascular Diseases
 Neoplasms Antibodies  >10 publications with APOA2 and Neoplasms
 Atherosclerosis Antibodies  >10 publications with APOA2 and Atherosclerosis
 Liver Diseases Antibodies  >9 publications with APOA2 and Liver Diseases
 Insulin Resistance Antibodies  >7 publications with APOA2 and Insulin Resistance
 Diabetes Mellitus, Type 2 Antibodies  >7 publications with APOA2 and Diabetes Mellitus, Type 2
 Neurodegenerative Diseases Antibodies  >5 publications with APOA2 and Neurodegenerative Diseases
 Kidney Diseases Antibodies  >4 publications with APOA2 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >48 publications with APOA2 and Blood
 Liver Antibodies  >16 publications with APOA2 and Liver
 Heart Antibodies  >12 publications with APOA2 and Heart
 Kidney Antibodies  >5 publications with APOA2 and Kidney
 Intestine Antibodies  >4 publications with APOA2 and Intestine
 Muscle Antibodies  >3 publications with APOA2 and Muscle
 Placenta Antibodies  >3 publications with APOA2 and Placenta
 Brain Antibodies  >2 publications with APOA2 and Brain
 Lung Antibodies  >2 publications with APOA2 and Lung
 Spleen Antibodies  >2 publications with APOA2 and Spleen
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