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APOC3 native protein :: Apolipoprotein CIII (Apo CIII) Native Protein

Scan QR to view Datasheet Catalog #    MBS318091 APOC3 native protein
Unit / Price
0.1 mg  /  $225 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Apolipoprotein CIII (Apo CIII) (APOC3), Native Protein

★Popular Item★
 Also Known As   

Human Apolipoprotein CIII

 Product Synonym Names    Human Apolipoprotein CIII (Apo CIII)
 Product Gene Name   

APOC3 native protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 11; NC_000011.9 (116700624..116703787). Location: 11q23.1-q23.2
 OMIM    107720
 3D Structure    ModBase 3D Structure for P02656
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 Host    Human plasma, Very Low Density Lipoprotein (VLDL)
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 Specificity    Apolipoprotein CIII (Apo CIII)
 Purity/Purification    >=95% pure (SDS-PAGE)
 Form/Format    Purified, Lyophilized
Reconstitute with 59.9ul distilled water.
 Concentration    1.67mg/ml (prior to lyophilization) (lot specific)
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 Inactivation    Not applicable
 Buffer    Lyophilized from 10mM NH4HCO3, pH 7.4
 Preservative    No
 Lyophilized    Yes
 Warnings    All human source materials have tested non-reactive for HBsAg, anti-HCV, anti-HBc and negative for anti-HIV 1 and HIV 2 by FDA required tests. No test guarantees a product to be non-infectious. Therefore, all material derived from human fluids o
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 Preparation and Storage    Store at -20 degree C. Avoid multiple freeze/thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of APOC3 native protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for APOC3 native protein    Purified Lipoproteins
NCBI/Uniprot data below describe general gene information for APOC3. It may not necessarily be applicable to this product.
 NCBI GI #    4557323
 NCBI GeneID    345
 NCBI Accession #    NP_000031.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000040.1 [Other Products]
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 UniProt Primary Accession #    P02656 [Other Products]
 UniProt Secondary Accession #    Q08E83; Q6Q786 [Other Products]
 UniProt Related Accession #    P02656 [Other Products]
 Molecular Weight    10,852 Da [Similar Products]
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 NCBI Official Full Name    apolipoprotein C-III
 NCBI Official Synonym Full Names    apolipoprotein C-III
 NCBI Official Symbol    APOC3 [Similar Products]
 NCBI Official Synonym Symbols   
APOCIII; MGC150353
[Similar Products]
 NCBI Protein Information    apolipoprotein C-III; apo-CIII; apoC-III; apolipoprotein C3; OTTHUMP00000043270; OTTHUMP00000069353
 UniProt Protein Name    Apolipoprotein C-III
 UniProt Synonym Protein Names   
Apolipoprotein C3
 Protein Family    Apolipoprotein
 UniProt Gene Name    APOC3 [Similar Products]
 UniProt Entry Name    APOC3_HUMAN
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 NCBI Summary for APOC3    Apolipoprotein C-III is a very low density lipoprotein (VLDL) protein. APOC3 inhibits lipoprotein lipase and hepatic lipase; it is thought to delay catabolism of triglyceride-rich particles. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the A-1 and C-III genes are convergently transcribed. An increase in apoC-III levels induces the development of hypertriglyceridemia. [provided by RefSeq]
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 UniProt Comments for APOC3    Function: Inhibits lipoprotein lipase and hepatic lipase and decreases the uptake of lymph chylomicrons by hepatic cells. This suggests that it delays the catabolism of triglyceride-rich particles.

Subcellular location: Secreted.

Tissue specificity: Constitutes 50% of the protein fraction of VLDL and 2% of that of HDL. Synthesized predominantly in liver and to a lesser degree in intestine.

Post-translational modification: O-linked glycan consists of Gal-GalNAc disaccharide, further modified with up to 3 sialic acid residues. O-glycosylated on Thr-94 with a core 1 or possibly core 8 glycan. Ref.9 Ref.10

Involvement in disease: Defects in APOC3 may be a cause of hyperalphalipoproteinemia (HYPALIP) [

MIM:143470]. Affected individuals show high levels of alpha-lipoprotein (high density lipoprotein/HDL). Ref.11

Sequence similarities: Belongs to the apolipoprotein C3 family.
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 Research Articles on APOC3    1. Data suggest that apoC-III attenuates the binding of apoE to the lipoprotein surface and apoE-mediated cellular uptake of lipoprotein remnants.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with APOC3 native proteinDiseases associated with APOC3 native protein
 Products by Pathway  Pathway Diagram
 Chylomicron-mediated Lipid Transport Pathway antibodies  Chylomicron-mediated Lipid Transport Pathway Diagram
 HDL-mediated Lipid Transport Pathway antibodies  HDL-mediated Lipid Transport Pathway Diagram
 Lipid Digestion, Mobilization, And Transport Pathway antibodies  Lipid Digestion, Mobilization, And Transport Pathway Diagram
 Lipoprotein Metabolism Pathway antibodies  Lipoprotein Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 PPAR Signaling Pathway antibodies  PPAR Signaling Pathway Diagram
 PPAR Signaling Pathway antibodies  PPAR Signaling Pathway Diagram
 Statin Pathway antibodies  Statin Pathway Diagram
 Disease Name  Pubmed Publications
 Metabolic Diseases Antibodies  >78 publications with APOC3 and Metabolic Diseases
 Coronary Disease Antibodies  >44 publications with APOC3 and Coronary Disease
 Hypertriglyceridemia Antibodies  >39 publications with APOC3 and Hypertriglyceridemia
 Dyslipidemias Antibodies  >38 publications with APOC3 and Dyslipidemias
 Hyperlipidemias Antibodies  >32 publications with APOC3 and Hyperlipidemias
 Insulin Resistance Antibodies  >29 publications with APOC3 and Insulin Resistance
 Arteriosclerosis Antibodies  >27 publications with APOC3 and Arteriosclerosis
 Hyperinsulinism Antibodies  >20 publications with APOC3 and Hyperinsulinism
 Obesity Antibodies  >19 publications with APOC3 and Obesity
 Diabetes Mellitus, Type 2 Antibodies  >19 publications with APOC3 and Diabetes Mellitus, Type 2
Organs/Tissues associated with APOC3 native protein
 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >34 publications with APOC3 and Heart
 Liver Antibodies  >27 publications with APOC3 and Liver
 Connective Tissue Antibodies  >5 publications with APOC3 and Connective Tissue
 Brain Antibodies  >1 publications with APOC3 and Brain
 Muscle Antibodies  >1 publications with APOC3 and Muscle
 Kidney Antibodies  >1 publications with APOC3 and Kidney
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