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| Product Name
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Apolipoprotein CIII (Apo CIII) (APOC3), Native Protein ★Popular Item★
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| Also Known As
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Human Apolipoprotein CIII
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| Product Synonym Names
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Human Apolipoprotein CIII (Apo CIII)
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| Product Gene Name
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[Similar Products]
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| Research Use Only
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For Research Use Only. Not for use in diagnostic procedures.
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 TOP
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| Chromosome Location
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Chromosome: 11; NC_000011.9 (116700624..116703787). Location: 11q23.1-q23.2
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| OMIM
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107720
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| 3D Structure
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ModBase 3D Structure for P02656
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| Host
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Human plasma, Very Low Density Lipoprotein (VLDL)
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| Specificity
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Apolipoprotein CIII (Apo CIII)
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| Purity/Purification
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>=95% pure (SDS-PAGE)
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| Form/Format
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Purified, Lyophilized
Reconstitute with 59.9ul distilled water.
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| Concentration
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1.67mg/ml (prior to lyophilization) (lot specific)
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| Inactivation
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Not applicable
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| Buffer
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Lyophilized from 10mM NH4HCO3, pH 7.4
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| Preservative
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No
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| Lyophilized
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Yes
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| Warnings
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All human source materials have tested non-reactive for HBsAg, anti-HCV, anti-HBc and negative for anti-HIV 1 and HIV 2 by FDA required tests. No test guarantees a product to be non-infectious. Therefore, all material derived from human fluids o
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| Preparation and Storage
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Store at -20 degree C. Avoid multiple freeze/thaw cycles.
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| ISO Certification
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Manufactured in an ISO 9001:2008 Certified Laboratory.
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| Other Notes
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Small volumes of APOC3 native protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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TOP
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| Product Categories/Family for APOC3 native protein
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Purified Lipoproteins
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| NCBI/Uniprot data below describe general gene information for APOC3. It may not necessarily be applicable to this product. |
| NCBI GI #
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4557323
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| NCBI GeneID
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345
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| NCBI Accession #
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NP_000031.1
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[Other Products]
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| NCBI GenBank Nucleotide #
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NM_000040.1
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[Other Products]
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| UniProt Primary Accession #
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P02656
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[Other Products]
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| UniProt Secondary Accession #
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Q08E83; Q6Q786
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[Other Products]
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| UniProt Related Accession #
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P02656
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[Other Products]
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| Molecular Weight
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10,852 Da
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[Similar Products]
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TOP
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| NCBI Official Full Name
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apolipoprotein C-III
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| NCBI Official Synonym Full Names
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apolipoprotein C-III
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| NCBI Official Symbol
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APOC3
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[Similar Products]
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| NCBI Official Synonym Symbols
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APOCIII; MGC150353
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[Similar Products]
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| NCBI Protein Information
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apolipoprotein C-III; apo-CIII; apoC-III; apolipoprotein C3; OTTHUMP00000043270; OTTHUMP00000069353
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| UniProt Protein Name
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Apolipoprotein C-III
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| UniProt Synonym Protein Names
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Apolipoprotein C3
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| Protein Family
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Apolipoprotein
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| UniProt Gene Name
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APOC3
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[Similar Products]
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| UniProt Entry Name
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APOC3_HUMAN
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| NCBI Summary for APOC3
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Apolipoprotein C-III is a very low density lipoprotein (VLDL) protein. APOC3 inhibits lipoprotein lipase and hepatic lipase; it is thought to delay catabolism of triglyceride-rich particles. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the A-1 and C-III genes are convergently transcribed. An increase in apoC-III levels induces the development of hypertriglyceridemia. [provided by RefSeq]
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| UniProt Comments for APOC3
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Function: Inhibits lipoprotein lipase and hepatic lipase and decreases the uptake of lymph chylomicrons by hepatic cells. This suggests that it delays the catabolism of triglyceride-rich particles.
Subcellular location: Secreted.
Tissue specificity: Constitutes 50% of the protein fraction of VLDL and 2% of that of HDL. Synthesized predominantly in liver and to a lesser degree in intestine.
Post-translational modification: O-linked glycan consists of Gal-GalNAc disaccharide, further modified with up to 3 sialic acid residues. O-glycosylated on Thr-94 with a core 1 or possibly core 8 glycan. Ref.9 Ref.10
Involvement in disease: Defects in APOC3 may be a cause of hyperalphalipoproteinemia (HYPALIP) [
MIM:143470]. Affected individuals show high levels of alpha-lipoprotein (high density lipoprotein/HDL). Ref.11
Sequence similarities: Belongs to the apolipoprotein C3 family.
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TOP
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| Research Articles on APOC3
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1. Data suggest that apoC-III attenuates the binding of apoE to the lipoprotein surface and apoE-mediated cellular uptake of lipoprotein remnants.
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TOP
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| Precautions
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All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
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| Disclaimer
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While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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TOP
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| Pathways associated with APOC3 native protein | Diseases associated with APOC3 native protein |
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| Organs/Tissues associated with APOC3 native protein |
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TOP
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Native Protein 
