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BPI native protein :: Bactericidal/Permeability-Increasing Native Protein

Scan QR to view Datasheet Catalog #    MBS145436 BPI native protein
Unit / Price
0.002 mg  /  $140 +1 FREE 8GB USB
0.01 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $5,015 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Bactericidal/Permeability-Increasing (BPI), Native Protein

★Popular Item★
 Also Known As   

Human Bactericidal/Permeability-Increasing Protein

 Product Synonym Names    BPI Human; Bactericidal/Permeability-Increasing Protein Human; Bactericidal/permeability-increasing protein; CAP 57
 Product Gene Name   

BPI native protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    109195
 3D Structure    ModBase 3D Structure for P17213
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 Purity/Purification    Greater than 70% as determined by SDS-PAGE and capillary electrophoresis.
 Form/Format    BPI (1.15mg/ml) is supplied in 25mM Sodium Acetate pH-4.6.
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 Physical Appearance    Sterile filtered colorless solution
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 Preparation and Storage    Store at 4C if entire vial will be used within 2-4 weeks.
Store, frozen at -20C for longer periods of time.
Avoid multiple freeze-thaw cycles.
 Other Notes    Small volumes of BPI native protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for BPI native protein

   Description: The native protein BPI is isolated from human buffy coats and has a molecular mass of 53kDa.

Introduction: BPI encodes a lipopolysaccharide binding protein. BPI is related to human neutrophil granules and has bactericidal activity on gram-negative organisms.
 Product Categories/Family for BPI native protein    RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins
NCBI/Uniprot data below describe general gene information for BPI. It may not necessarily be applicable to this product.
 NCBI GI #    157276599
 NCBI GeneID    671
 NCBI Accession #    NP_001716.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001725.2 [Other Products]
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 UniProt Primary Accession #    P17213 [Other Products]
 UniProt Secondary Accession #    Q1ZZU8; Q5JRW0; Q8IW58; Q9BYZ9; Q9H1L2; Q9H1M8; Q9H203; Q9UCT4; Q9UD65; B2RCY2 [Other Products]
 UniProt Related Accession #    P17213 [Other Products]
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 NCBI Official Full Name    bactericidal permeability-increasing protein
 NCBI Official Synonym Full Names    bactericidal/permeability-increasing protein
 NCBI Official Symbol    BPI [Similar Products]
 NCBI Official Synonym Symbols   
rBPI; BPIFD1
[Similar Products]
 NCBI Protein Information    bactericidal permeability-increasing protein; BPI fold containing family D, member 1; CAP 57; recombinant BPI holoprotein, rBPI
 UniProt Protein Name    Bactericidal permeability-increasing protein
 UniProt Synonym Protein Names   
CAP 57
 Protein Family    Bactericidal permeability-increasing protein
 UniProt Gene Name    BPI [Similar Products]
 UniProt Synonym Gene Names    BPI [Similar Products]
 UniProt Entry Name    BPI_HUMAN
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 NCBI Summary for BPI    This gene encodes a lipopolysaccharide binding protein. It is associated with human neutrophil granules and has antimicrobial activity against gram-negative organisms. [provided by RefSeq, Nov 2014]
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 UniProt Comments for BPI    BPI: The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.

Protein type: Cell surface; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 20q11.23

Cellular Component: integral to plasma membrane; cytoplasm

Molecular Function: lipopolysaccharide binding

Biological Process: negative regulation of interleukin-6 production; negative regulation of interleukin-8 production; immune response; negative regulation of tumor necrosis factor production; negative regulation of macrophage activation; defense response to Gram-negative bacterium
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 Research Articles on BPI    1. This review article focuses on the structural and functional properties of BPI with respect to its antimicrobial contribution to host defense during GNB infections and endotoxin-induced inflammation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with BPI native proteinOrgans/Tissues associated with BPI native protein
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >76 publications with BPI and Necrosis
 Brain Diseases Antibodies  >62 publications with BPI and Brain Diseases
 Fibrosis Antibodies  >39 publications with BPI and Fibrosis
 Skin Diseases Antibodies  >37 publications with BPI and Skin Diseases
 Nausea Antibodies  >31 publications with BPI and Nausea
 Disease Models, Animal Antibodies  >30 publications with BPI and Disease Models, Animal
 Recurrence Antibodies  >17 publications with BPI and Recurrence
 Urologic Diseases Antibodies  >15 publications with BPI and Urologic Diseases
 Arthritis, Rheumatoid Antibodies  >13 publications with BPI and Arthritis, Rheumatoid
 Abdominal Pain Antibodies  >10 publications with BPI and Abdominal Pain
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >494 publications with BPI and Blood
 Brain Antibodies  >84 publications with BPI and Brain
 Bone Antibodies  >81 publications with BPI and Bone
 Liver Antibodies  >38 publications with BPI and Liver
 Kidney Antibodies  >31 publications with BPI and Kidney
 Heart Antibodies  >27 publications with BPI and Heart
 Bone Marrow Antibodies  >16 publications with BPI and Bone Marrow
 Connective Tissue Antibodies  >5 publications with BPI and Connective Tissue
 Ovary Antibodies  >5 publications with BPI and Ovary
 Thyroid Antibodies  >4 publications with BPI and Thyroid
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