Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Native Protein rightarrow SERPING1  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • dishevelled, dsh homolog 2 (Drosophila) (DVL2) ELISA Kit
 • Interferon Gamma Receptor 1 (IFN-gamma R1) ELISA Kit
 • transforming growth factor, beta receptor III (TGFBR3) ELISA Kit
 • epidemic diarrhea virus antibody, PEDV ELISA Kit
 • Activation-induced cytidine deaminase (AICDA) ELISA Kit
 • ZNT1 (SLC30A1) Antibody
 • AMT cDNA Clone
 • Vimentin Antibody
 • ALP ELISA Kit
 • ANAPC (ANAPC5) Blocking Peptide
 • MBP ELISA Kit
 • Adapter molecule crk (CRK) ELISA Kit
 • EPHA2-3-4 Antibody
 • Leucine-rich repeat and immunoglobulin-like domain-containin... Recombinant Protein
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

SERPING1 native protein :: C1 Inhibitor (Esterase Inhibitor) Native Protein

Scan QR to view Datasheet Catalog #    MBS318174 SERPING1 native protein
Unit / Price
1 mg  /  $295 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

C1 Inhibitor (Esterase Inhibitor) (SERPING1), Native Protein

★Popular Item★
 Also Known As   

C1 Esterase Inhibitor

 Product Synonym Names    Human C1 Esterase Inhibitor
 Product Gene Name   

SERPING1 native protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 Chromosome Location    Chromosome: 11; NC_000011.9 (57365027..57382326). Location: 11q12-q13.1
 OMIM    106100
 3D Structure    ModBase 3D Structure for P05155
Section Bar
 Host    Human, Plasma
Section Bar
 Purity/Purification    >95% pure (SDS-PAGE)
 Form/Format    Purified, Liquid
 Concentration    2.14 mg/ml (lot specific)
Section Bar
 Buffer    20mM Potassium phosphate, pH 7.0 containing 250mM Potassium chloride
 Preservative    None
Section Bar
 Preparation and Storage    Store at -70C.
Avoid multiple freeze/thaw cycles
Shipping: Ships with dry ice
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of SERPING1 native protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for SERPING1 native protein

   C1 Esterase Inhibitor
Human C1 Esterase Inhibitor
 Product Categories/Family for SERPING1 native protein    Purified Enzymes
 Applications Tested/Suitable for SERPING1 native protein   

Specific methodologies have not been tested using this product

Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for SERPING1. It may not necessarily be applicable to this product.
 NCBI GI #    1197499
 NCBI GeneID    710
 NCBI Accession #    CAA30314 [Other Products]
Section Bar
 UniProt Primary Accession #    P05155 [Other Products]
 UniProt Secondary Accession #    Q16304; Q547W3; Q59EI5; Q7Z455; Q96FE0; Q9UC49; Q9UCF9; A6NMU0; A8KAI9; B2R6L5 [Other Products]
 UniProt Related Accession #    P05155; Q5UGI5; Q5UGI6 [Other Products]
 Molecular Weight    55,154 Da [Similar Products]
Table BarTOPTable Bar
 NCBI Official Full Name    C1 inhibitor
 NCBI Official Synonym Full Names    serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
 NCBI Official Symbol    SERPING1 [Similar Products]
 NCBI Official Synonym Symbols   
C1IN; C1NH; HAE1; HAE2; C1INH
[Similar Products]
 NCBI Protein Information    plasma protease C1 inhibitor; serpin G1; OTTHUMP00000197003; OTTHUMP00000197004; OTTHUMP00000197007; OTTHUMP00000235286; OTTHUMP00000235287; C1-inhibiting factor; C1 esterase inhibitor; complement component 1 inhibitor; serine/cysteine proteinase inhibitor clade G member 1
 UniProt Protein Name    Plasma protease C1 inhibitor
 UniProt Synonym Protein Names   
C1 esterase inhibitor; C1-inhibiting factor; Serpin G1
 Protein Family    Plasma protease C1 inhibitor
 UniProt Gene Name    SERPING1 [Similar Products]
 UniProt Synonym Gene Names    C1IN; C1NH [Similar Products]
 UniProt Entry Name    IC1_HUMAN
Section Bar
 NCBI Summary for SERPING1    This gene encodes a highly glycosylated plasma protein involved in the regulation of the complement cascade. Its protein inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. Deficiency of this protein is associated with hereditary angioneurotic oedema (HANE). Alternative splicing results in multiple transcript variants encoding the same isoform. [provided by RefSeq]
Section Bar
 UniProt Comments for SERPING1    Function: Activation of the C1 complex is under control of the C1-inhibitor. It forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Inhibits chymotrypsin and kallikrein. Ref.21

Subunit structure: Binds to E.coli stcE which allows localization of SERPING1 to cell membranes thus protecting the bacteria against complement-mediated lysis. Interacts with MASP1. Ref.22 Ref.23 Ref.25

Subcellular location: Secreted.

Post-translational modification: Highly glycosylated (49%) with N- and O-glycosylation. Ref.2 Ref.24 Ref.26 Ref.27 Ref.28 Ref.29 Ref.30 Ref.31Can be proteolytically cleaved by E.coli stcE. Ref.23 Ref.25

Polymorphism: Chymotrypsin uses Ala-465 as its reactive site in normal plasma protease C1 inhibitor, and His-466 as its reactive site in the variant His-466.

Involvement in disease: Defects in SERPING1 are the cause of hereditary angioedema (HAE) [

MIM:106100]; also called hereditary angioneurotic edema (HANE). HAE is an autosomal dominant disorder characterized by episodic local subcutaneous edema and submucosal edema involving the upper respiratory and gastrointestinal tracts. HAE due to C1 esterase inhibitor deficiency is comprised of two clinically indistinguishable forms. In HAE type 1, representing 85% of patients, serum levels of C1 esterase inhibitor are less than 35% of normal. In HAE type 2, the levels are normal or elevated, but the protein is non-functional. Ref.14 Ref.20 Ref.33 Ref.34 Ref.35 Ref.36 Ref.37 Ref.38 Ref.39 Ref.40 Ref.41 Ref.42 Ref.43 Ref.44 Ref.45

Sequence similarities: Belongs to the serpin family.

Sequence caution: The sequence AAA53096.1 differs from that shown. Reason: Erroneous gene model prediction.
Table BarTOPTable Bar
 Research Articles on SERPING1    1. We did not find a significant association between SERPING1 and exudative age-related macular degeneration in our study
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with SERPING1 native proteinPathways associated with SERPING1 native protein
 Reference Product  PubMed Publications
 C1S native protein  >11 publications with SERPING1 and C1S
 C1R native protein  >7 publications with SERPING1 and C1R
 MASP2 native protein  >4 publications with SERPING1 and MASP2
 MASP1 native protein  >2 publications with SERPING1 and MASP1
 Products by Pathway  Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies  Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram
 Formation Of Platelet Plug Pathway antibodies  Formation Of Platelet Plug Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Intrinsic Pathway antibodies  Intrinsic Pathway Diagram
 Pertussis Pathway antibodies  Pertussis Pathway Diagram
 Pertussis Pathway antibodies  Pertussis Pathway Diagram
 Platelet Activation Pathway antibodies  Platelet Activation Pathway Diagram
Diseases associated with SERPING1 native proteinOrgans/Tissues associated with SERPING1 native protein
 Disease Name  Pubmed Publications
 Skin Diseases Antibodies  >93 publications with SERPING1 and Skin Diseases
 Angioedema Antibodies  >92 publications with SERPING1 and Angioedema
 Urticaria Antibodies  >91 publications with SERPING1 and Urticaria
 Edema Antibodies  >41 publications with SERPING1 and Edema
 Genetic Diseases, Inborn Antibodies  >37 publications with SERPING1 and Genetic Diseases, Inborn
 Angioedemas, Hereditary Antibodies  >37 publications with SERPING1 and Angioedemas, Hereditary
 Inflammation Antibodies  >17 publications with SERPING1 and Inflammation
 Pain Antibodies  >12 publications with SERPING1 and Pain
 Hematologic Diseases Antibodies  >10 publications with SERPING1 and Hematologic Diseases
 Neoplasms Antibodies  >7 publications with SERPING1 and Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >55 publications with SERPING1 and Blood
 Vascular Antibodies  >16 publications with SERPING1 and Vascular
 Skin Antibodies  >16 publications with SERPING1 and Skin
 Larynx Antibodies  >9 publications with SERPING1 and Larynx
 Heart Antibodies  >5 publications with SERPING1 and Heart
 Eye Antibodies  >5 publications with SERPING1 and Eye
 Kidney Antibodies  >4 publications with SERPING1 and Kidney
 Intestine Antibodies  >4 publications with SERPING1 and Intestine
 Muscle Antibodies  >3 publications with SERPING1 and Muscle
 Liver Antibodies  >3 publications with SERPING1 and Liver
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions