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CEACAM6 native protein :: Carcinoembryonic Antigen (CEA) Antigen Grade Native Protein

Scan QR to view Datasheet Catalog #    MBS318072 CEACAM6 native protein
Unit / Price
1 mg  /  $1,185 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Carcinoembryonic Antigen (CEA) Antigen Grade (CEACAM6), Native Protein

 Also Known As   

CEA Antigen (Antigen Grade)

 Product Synonym Names    Carcinoembryonic Antigen (CEA) Antigen Grade
 Product Gene Name   

CEACAM6 native protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    chromosome: 19; Location: 19q13.2
 3D Structure    ModBase 3D Structure for Q13985
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 Host    Cell culture
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 Specificity    Carcinoembryonic Antigen (CEA) Antigen Grade
 Purity/Purification    >95% pure (SDS-PAGE). Immunoaffinity chromatography
Single band with 10ug load (PAGE Electrophoresis)
Product is 0.2um filtered.
 Form/Format    Affinity Purified, Liquid
 Concentration    2.29mg/ml (EIA correlated to Abbott AxSYM)
Total protein: 2.16 OD280 Units (lot specific)
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 Inactivation    Not applicable
 Buffer    PBS, pH 7.4 +/- 0.2
 Preservative    0.1% Sodium azide
 Warnings    This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1-1.0%. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.
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 Preparation and Storage    Short-term store at 2 to 8 degree C. Long term store at -20 degree C. Avoid multiple freeze/thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of CEACAM6 native protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for CEACAM6 native protein    Purified Reagents for Cancer Research
NCBI/Uniprot data below describe general gene information for CEACAM6. It may not necessarily be applicable to this product.
 NCBI GI #    553222
 NCBI GeneID    4680
 NCBI Accession #    AAA51971.1 [Other Products]
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 UniProt Primary Accession #    Q13985 [Other Products]
 UniProt Related Accession #    P40199; Q13985; Q14921; Q14922; Q53XP7 [Other Products]
 Molecular Weight    15,545 Da [Similar Products]
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 NCBI Official Full Name    carcinoembryonic antigen
 NCBI Official Synonym Full Names    carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
 NCBI Official Symbol    CEACAM6 [Similar Products]
 NCBI Official Synonym Symbols   
NCA; CEAL; CD66c; CEACAM6
[Similar Products]
 NCBI Protein Information    carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
 UniProt Protein Name    Carcinoembryonic antigen
 Protein Family    Carcinoembryonic antigen-related cell adhesion molecule
 UniProt Gene Name    CEA [Similar Products]
 UniProt Entry Name    Q13985_HUMAN
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 NCBI Summary for CEACAM6    Carcinoembryonic antigen (CEA; MIM 114890) is one of the most widely used tumor markers in serum immunoassay determinations of carcinoma. An apparent lack of absolute cancer specificity for CEA probably results in part from the presence in normal and neoplastic tissues of antigens that share antigenic determinants with the 180-kD form of CEA (Barnett et al., 1988 [PubMed 3220478]). For background information on the CEA family of genes, see CEACAM1 (MIM 109770).[supplied by OMIM]
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 UniProt Comments for CEACAM6    CEACAM6: Belongs to the immunoglobulin superfamily. CEA family

Protein type: Membrane protein, GPI anchor; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: protein binding

Biological Process: cell-cell signaling; signal transduction; blood coagulation; leukocyte migration
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 Research Articles on CEACAM6    1. CEACAM6-associated signaling pathways could be potential targets for the development of biomarkers to predict the response of patients to adenovirus-based therapies, as well as for the development of more potent adenovirus-based therapeutics
2. Because CEACAM6 acts as an antiapoptotic factor and stabilizes surfactant function, in addition to a putative role in innate defense against bacteria, we propose that it is a multifunctional alveolar protein
3. Data show that desensitization of neutrophils to any two CEACAMs, 1, 3, 6, or 8, results in selective desensitization to those two CEACAMs, while the cells remain responsive to the other two neutrophil CEACAMs.
4. CEACAM6 is overexpressed in borderline and invasive mucinous ovarian neoplasms.
5. findings suggest that CEA (CEACAM5) and CEACAM6 are major target genes for Smad3-mediated TGF-beta signaling.
6. All the leukemic samples showed overexpression of CEACAM6 and 8 when compared with normal granulocytes.
7. data support an important role for CEACAM6 in endocrine resistance in breast cancer, which can serve as a powerful predictor of future recurrence
8. Observational study of gene-disease association. (HuGE Navigator)
9. The expression of CEACAM6 in ADH lesions is strongly associated with the development of IBC, therefore, it can be applied as a diagnostic marker either singly or in combination with other marker(s) to predict IBC development in women with ADH lesions.
10. CEACAM6 is a biological tumor marker for epithelial ovarian cancers.
11. the results show that recognition of CEA and CEACAM6, but not CEACAM1, is accompanied by tight attachment to bacteria of cell surface microvilli-like extensions
12. For all tumors, the amount of CEACAM6 expressed was greater than that of CEACAM5, and reflected tumor histotype.
13. CEACAM6 subdomains involved in intercellular adhesion activity and subdomains involved in inhibition of cell differentation are identified and their respective activities are independently blocked.
14. overexpression among human malignancies, immunological targeting of this tumor antigen may have therapeutic applicability
15. Levels of CEACAM6 expression can modulate pancreatic adenocarcinoma cellular invasiveness in a c-Src-dependent manner
16. Data show that variants of Neisseria gonorrhoeae that bind to human carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) 1 and 6 failed to induce detachment and, instead, promoted enhanced host cell adhesion to the ECM.
17. CEACAM6 gene silencing reversed the acquired anoikis resistance of tumor cell lines and inhibited in vivo metastatic ability
18. CEACAM6 is an important determinant of pancreatic adenocarcinoma malignant cellular behavior
19. CD66c is regulated in a manner distinct from other myeloid antigens in childhood lymphoblastic leukemia
20. Overexpression of CEACAM6 disrupts tissue architecture and blocks colonocyte differentiation
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CEACAM6 native proteinDiseases associated with CEACAM6 native protein
 Reference Product  PubMed Publications
 CEACAM1 native protein  >43 publications with CEACAM6 and CEACAM1
 CEACAM8 native protein  >16 publications with CEACAM6 and CEACAM8
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >66 publications with CEACAM6 and Neoplasms
 Adenocarcinoma Antibodies  >23 publications with CEACAM6 and Adenocarcinoma
 Inflammation Antibodies  >11 publications with CEACAM6 and Inflammation
 Lymphoma Antibodies  >9 publications with CEACAM6 and Lymphoma
 Breast Neoplasms Antibodies  >9 publications with CEACAM6 and Breast Neoplasms
 Lung Neoplasms Antibodies  >8 publications with CEACAM6 and Lung Neoplasms
 Stomach Neoplasms Antibodies  >8 publications with CEACAM6 and Stomach Neoplasms
 Leukemia, Myeloid, Acute Antibodies  >8 publications with CEACAM6 and Leukemia, Myeloid, Acute
 Necrosis Antibodies  >6 publications with CEACAM6 and Necrosis
 Neoplasms, Experimental Antibodies  >4 publications with CEACAM6 and Neoplasms, Experimental
Organs/Tissues associated with CEACAM6 native protein
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >5621 publications with CEACAM6 and Blood
 Lung Antibodies  >1783 publications with CEACAM6 and Lung
 Stomach Antibodies  >1037 publications with CEACAM6 and Stomach
 Skin Antibodies  >459 publications with CEACAM6 and Skin
 Intestine Antibodies  >454 publications with CEACAM6 and Intestine
 Pancreas Antibodies  >432 publications with CEACAM6 and Pancreas
 Muscle Antibodies  >348 publications with CEACAM6 and Muscle
 Kidney Antibodies  >307 publications with CEACAM6 and Kidney
 Bladder Antibodies  >248 publications with CEACAM6 and Bladder
 Prostate Antibodies  >233 publications with CEACAM6 and Prostate
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