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CTSB native protein :: Cathepsin B Native Protein

Scan QR to view Datasheet Catalog #    MBS318180 CTSB native protein
Unit / Price
0.025 mg  /  $310 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Cathepsin B (CTSB), Native Protein

★Popular Item★
 Also Known As   

Human Cathepsin B

 Product Gene Name   

CTSB native protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 8; NC_007306.4 (7457578..7466062)
 3D Structure    ModBase 3D Structure for P07688
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 Host    Human Liver
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 Specificity    Cathepsin B
 Purity/Purification    >95% pure (SDS-PAGE)
 Form/Format    Purified, Liquid
 Concentration    Total protein: 0.37mg/ml
Specific Activity: 385 Units/mg protein using Z-Arg-Arg-beta-NA as a substrate. One unit is defined as the amount of enzyme that hydrolyzes one umole of 2-naphtylamine per minute at 40 degree C, pH 6.0, in the presence of DTT> (lot specific)
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 Inactivation    Not applicable.
 Buffer    50mM Sodium acetate, pH 5.0, with 1mM EDTA
 Preservative    No
 Dry Ice Shipment    Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
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 Preparation and Storage    Store at -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of CTSB native protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for CTSB native protein

   Prepared from liver tissue that was shown to be nonreactive for HBsAg, anti-HCV, anti HBc, and negative for anti-HIV 1 & 2 by FDA required tests
 Product Categories/Family for CTSB native protein    Purified Enzymes
NCBI/Uniprot data below describe general gene information for CTSB. It may not necessarily be applicable to this product.
 NCBI GI #    27806671
 NCBI GeneID    281105
 NCBI Accession #    NP_776456.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_174031.2 [Other Products]
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 UniProt Primary Accession #    P07688 [Other Products]
 UniProt Secondary Accession #    Q3ZC03 [Other Products]
 UniProt Related Accession #    P07688; Q003W4; Q6DW13; Q9MZF5 [Other Products]
 Molecular Weight    36,661 Da [Similar Products]
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 NCBI Official Full Name    cathepsin B
 NCBI Official Symbol    CTSB [Similar Products]
 NCBI Official Synonym Symbols   
CTSB
[Similar Products]
 NCBI Protein Information    cathepsin B; BCSB
 UniProt Protein Name    Cathepsin B
 UniProt Synonym Protein Names   
BCSB
 Protein Family    Cathepsin
 UniProt Gene Name    CTSB [Similar Products]
 UniProt Entry Name    CATB_BOVIN
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 UniProt Comments for CTSB    Function: Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.

Catalytic activity: Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially cleaves -Arg-Arg-|-Xaa bonds in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides.

Subunit structure: Interacts with SRPX2

By similarity. Dimer of a heavy chain and a light chain cross-linked by a disulfide bond.

Subcellular location: Lysosome. Melanosome

Sequence similarities: Belongs to the peptidase C1 family.
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 Research Articles on CTSB    1. The peptides, all of which contain a C-terminal free acid, were tested as inactivators of bovine cathepsin B, in an attempt at exploiting the known and, amongst the cysteine proteinases, unique carboxy dipeptidyl peptidase activity of the protease.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with CTSB native proteinDiseases associated with CTSB native protein
 Products by Pathway  Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >53 publications with CTSB and Neoplasms
 Inflammation Antibodies  >18 publications with CTSB and Inflammation
 Adenocarcinoma Antibodies  >15 publications with CTSB and Adenocarcinoma
 Liver Diseases Antibodies  >12 publications with CTSB and Liver Diseases
 Lung Neoplasms Antibodies  >11 publications with CTSB and Lung Neoplasms
 Head and Neck Neoplasms Antibodies  >9 publications with CTSB and Head and Neck Neoplasms
 Female Urogenital Diseases Antibodies  >9 publications with CTSB and Female Urogenital Diseases
 Respiratory Tract Diseases Antibodies  >8 publications with CTSB and Respiratory Tract Diseases
 Breast Neoplasms Antibodies  >8 publications with CTSB and Breast Neoplasms
 Genital Neoplasms, Female Antibodies  >7 publications with CTSB and Genital Neoplasms, Female
Organs/Tissues associated with CTSB native protein
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >20 publications with CTSB and Blood
 Liver Antibodies  >17 publications with CTSB and Liver
 Lung Antibodies  >15 publications with CTSB and Lung
 Muscle Antibodies  >9 publications with CTSB and Muscle
 Brain Antibodies  >7 publications with CTSB and Brain
 Pancreas Antibodies  >7 publications with CTSB and Pancreas
 Uterus Antibodies  >6 publications with CTSB and Uterus
 Skin Antibodies  >4 publications with CTSB and Skin
 Kidney Antibodies  >4 publications with CTSB and Kidney
 Ovary Antibodies  >4 publications with CTSB and Ovary
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