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CTSG native protein :: Cathepsin G Native Protein

Scan QR to view Datasheet Catalog #    MBS318181 CTSG native protein
Unit / Price
0.1 mg  /  $430 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Cathepsin G (CTSG), Native Protein

★Popular Item★
 Also Known As   

Human Cathepsin G

 Product Gene Name   

CTSG native protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 14; NC_000014.8 (25042724..25045466, complement). Location: 14q11.2
 OMIM    116830
 3D Structure    ModBase 3D Structure for P08311
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 Host    Human Neutrophil
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 Specificity    Cathepsin G
 Purity/Purification    >95% pure (SDS-PAGE)
 Form/Format    Purified, Lyophilized
We suggest using 50mM Na Acetate, pH 5.5, with 150mM Sodium Chloride as the buffer to be added to the salt-free lyophilized solid.
 Concentration    Not applicable
Activity: 2 to 4 Units/mg protein. One unit of activity is defined as the amount of enzyme that hydrolyzes one micromole of Suc-ala-ala-pro-phe-pNA (1mM) per minute at 25 degree C in 160mM Tris-HCl, pH 7.4 containing 1.6M Sodium chloride (lot specific)
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 Inactivation    Not applicable.
 Buffer    Not applicable
 Preservative    No
 Lyophilized    Yes
 Warnings    All human source materials have tested negative for HIV 1, HIV 2 and non-reactive for anti-HCV, HBsAg and anti-HBc. No test guarantees a product to be non-infectious. Therefore, all material derived from human fluids or tissues should be conside
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 Preparation and Storage    Store at -20 degree C. Avoid multiple freeze/thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of CTSG native protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for CTSG native protein    Purified Enzymes
NCBI/Uniprot data below describe general gene information for CTSG. It may not necessarily be applicable to this product.
 NCBI GI #    179915
 NCBI GeneID    1511
 NCBI Accession #    AAA51919.1 [Other Products]
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 UniProt Primary Accession #    P08311 [Other Products]
 UniProt Secondary Accession #    Q6IBJ6; Q9UCA5; Q9UCU6 [Other Products]
 UniProt Related Accession #    P08311 [Other Products]
 Molecular Weight    28,837 Da [Similar Products]
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 NCBI Official Full Name    cathepsin G
 NCBI Official Synonym Full Names    cathepsin G
 NCBI Official Symbol    CTSG [Similar Products]
 NCBI Official Synonym Symbols   
CG; CATG; MGC23078
[Similar Products]
 NCBI Protein Information    cathepsin G; OTTHUMP00000178752
 UniProt Protein Name    Cathepsin G
 Protein Family    Cathepsin
 UniProt Gene Name    CTSG [Similar Products]
 UniProt Entry Name    CATG_HUMAN
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 NCBI Summary for CTSG    The protein encoded by this gene, a member of the peptidase S1 protein family, is found in azurophil granules of neutrophilic polymorphonuclear leukocytes. The encoded protease has a specificity similar to that of chymotrypsin C, and may participate in the killing and digestion of engulfed pathogens, and in connective tissue remodeling at sites of inflammation. Transcript variants utilizing alternative polyadenylation signals exist for this gene. [provided by RefSeq]
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 UniProt Comments for CTSG    Function: Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by LPS from P.aeruginosa, Z-Gly-Leu-Phe-CH2Cl and phenylmethylsulfonyl fluoride. Ref.6 Ref.9 Ref.11

Catalytic activity: Specificity similar to chymotrypsin C.

Enzyme regulation: Inhibited by soybean trypsin inhibitor, benzamidine, the synthetic peptide R13K, Z-Gly-Leu-Phe-CH2Cl, phenylmethylsulfonyl fluoride, 3,4-dichloroisocoumarin, DFP, SBTI and alpha-1-antitrypsin. Inhibited by LPS from P.aeruginosa but not by LPS from S.minnesota. Not inhibited by elastinal, CMK, TLCK and ETDA. Ref.6 Ref.9 Ref.11

Subcellular location: Cell surface Ref.6.

Sequence similarities: Belongs to the peptidase S1 family.Contains 1 peptidase S1 domain.

Biophysicochemical propertiesKinetic parameters:KM=1.15 mM for Z-Lys-SBzl Ref.6KM=0.26 mM for Suc-Ala-Ala-Pro-Phe-SBzl
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 Research Articles on CTSG    1. distinct catK/C4-S interactions are necessary for the collagenolytic activity of the enzyme.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CTSG native proteinPathways associated with CTSG native protein
 Reference Product  PubMed Publications
 THBS1 native protein  >6 publications with CTSG and THBS1
 PPBP native protein  >3 publications with CTSG and PPBP
 CXCR4 native protein  >3 publications with CTSG and CXCR4
 CXCL12 native protein  >3 publications with CTSG and CXCL12
 Products by Pathway  Pathway Diagram
 ACE Inhibitor Pathway antibodies  ACE Inhibitor Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Diabetes Pathways antibodies  Diabetes Pathways Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Regulation Of Insulin-like Growth Factor (IGF) Activity By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway antibodies  Regulation Of Insulin-like Growth Factor (IGF) Activity By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway Diagram
 Renin-angiotensin System Pathway antibodies  Renin-angiotensin System Pathway Diagram
Diseases associated with CTSG native proteinOrgans/Tissues associated with CTSG native protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >135 publications with CTSG and Inflammation
 Neoplasms Antibodies  >54 publications with CTSG and Neoplasms
 Leukemia Antibodies  >32 publications with CTSG and Leukemia
 Leukemia, Myeloid Antibodies  >29 publications with CTSG and Leukemia, Myeloid
 Fibrosis Antibodies  >27 publications with CTSG and Fibrosis
 Leukemia, Myeloid, Acute Antibodies  >25 publications with CTSG and Leukemia, Myeloid, Acute
 Arthritis, Rheumatoid Antibodies  >24 publications with CTSG and Arthritis, Rheumatoid
 Intestinal Diseases Antibodies  >20 publications with CTSG and Intestinal Diseases
 Colitis Antibodies  >18 publications with CTSG and Colitis
 Leukemia, Promyelocytic, Acute Antibodies  >11 publications with CTSG and Leukemia, Promyelocytic, Acute
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >601 publications with CTSG and Blood
 Skin Antibodies  >41 publications with CTSG and Skin
 Bone Antibodies  >37 publications with CTSG and Bone
 Connective Tissue Antibodies  >32 publications with CTSG and Connective Tissue
 Bone Marrow Antibodies  >27 publications with CTSG and Bone Marrow
 Liver Antibodies  >19 publications with CTSG and Liver
 Brain Antibodies  >17 publications with CTSG and Brain
 Kidney Antibodies  >16 publications with CTSG and Kidney
 Heart Antibodies  >15 publications with CTSG and Heart
 Eye Antibodies  >5 publications with CTSG and Eye
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