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CP native protein :: Ceruloplasmin Native Protein

Scan QR to view Datasheet Catalog #    MBS537196 CP native protein
Unit / Price
1 mg  /  $315 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Ceruloplasmin (CP), Native Protein

★Popular Item★
 Also Known As   

Ceruloplasmin protein

 Product Gene Name   

CP native protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    117700
 3D Structure    ModBase 3D Structure for P00450
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 Host    Human
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 Purity/Purification    > 95% pure
 Form/Format    Lyophilized from 50mM KH2PO4, pH 6.8, with 100mM KCl, 20mM E-amino caproic acid and 5mM EDTA. Reconstitute with deionized water to the pre-lyophilization volume.
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 Source Note    Human plasma
 Protein Type    Native
 Biological Significance    An acute-phase reactant. Increased levels are associated with normal pregnancy, rheumatoid arthritis, and cirrhosis. Decreased levels are associated with hepatolenticular degeneration (Wilson's Disease). An elevated level of Cp is found in patients with progressive tumors. Additionally, as Cp is a prooxidant, an elevated level is a sign of cardiovascular disease.
 Biohazard Information    Donor samples were tested and found to be negative for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2. Nonetheless caution should be used when handling this material as there is a margin of error in all tests.
 Dry Ice Shipment    Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
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 Preparation and Storage    Aliquot and store at -20 degree C. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of CP native protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for CP native protein

   Purified native Human Ceruloplasmin protein
 Product Categories/Family for CP native protein    Nutrition & Metabolism; Native Protein
 Applications Tested/Suitable for CP native protein   

User optimized

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NCBI/Uniprot data below describe general gene information for CP. It may not necessarily be applicable to this product.
 NCBI GI #    1731685
 NCBI GeneID    1356
 NCBI Accession #    BAA08085.1 [Other Products]
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 UniProt Primary Accession #    P00450 [Other Products]
 UniProt Secondary Accession #    Q14063; Q2PP18; Q9UKS4 [Other Products]
 UniProt Related Accession #    P00450 [Other Products]
 Molecular Weight    132 kDa [Similar Products]
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 NCBI Official Full Name    ceruloplasmin, partial
 NCBI Official Synonym Full Names    ceruloplasmin (ferroxidase)
 NCBI Official Symbol    CP [Similar Products]
 NCBI Official Synonym Symbols   
CP-2
[Similar Products]
 NCBI Protein Information    ceruloplasmin
 UniProt Protein Name    Ceruloplasmin
 UniProt Synonym Protein Names   
Ferroxidase
 Protein Family    Ceruloplasmin
 UniProt Gene Name    CP [Similar Products]
 UniProt Entry Name    CERU_HUMAN
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 NCBI Summary for CP    The protein encoded by this gene is a metalloprotein that binds most of the copper in plasma and is involved in the peroxidation of Fe(II)transferrin to Fe(III) transferrin. Mutations in this gene cause aceruloplasminemia, which results in iron accumulation and tissue damage, and is associated with diabetes and neurologic abnormalities. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Feb 2012]
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 UniProt Comments for CP    CP: Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. May also play a role in fetal lung development or pulmonary antioxidant defense. Defects in CP are the cause of aceruloplasminemia (ACERULOP). It is an autosomal recessive disorder of iron metabolism characterized by iron accumulation in the brain as well as visceral organs. Clinical features consist of the triad of retinal degeneration, diabetes mellitus and neurological disturbances. Ceruloplasmin levels are decreased in Wilson disease, in which copper cannot be incorporated into ceruloplasmin in liver because of defects in the copper-transporting ATPase 2. Belongs to the multicopper oxidase family.

Protein type: EC 1.16.3.1; Secreted, signal peptide; Secreted; Oxidoreductase; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll

Chromosomal Location of Human Ortholog: 3q23-q25

Cellular Component: extracellular space; lysosomal membrane; extracellular region

Molecular Function: ferroxidase activity; copper ion binding; chaperone binding

Biological Process: cellular iron ion homeostasis; copper ion transport; transmembrane transport

Disease: Aceruloplasminemia
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 Research Articles on CP    1. This review describes the main role of ceruloplasmin in iron turnover is oxidizing Fe2+ into Fe3+, a process which is essential for iron binding to transferrin (the main iron-transporting protein), as well as to ferritin (the main iron-storage protein)
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CP native proteinPathways associated with CP native protein
 Reference Product  PubMed Publications
 MPO native protein  >70 publications with CP and MPO
 HIF1A native protein  >18 publications with CP and HIF1A
 ATP7B native protein  >12 publications with CP and ATP7B
 ATP7A native protein  >9 publications with CP and ATP7A
 SLC40A1 native protein  >4 publications with CP and SLC40A1
 ARNT native protein  >2 publications with CP and ARNT
 SLC11A2 native protein  >1 publications with CP and SLC11A2
 Products by Pathway  Pathway Diagram
 HIF-1-alpha Transcription Factor Network Pathway antibodies  HIF-1-alpha Transcription Factor Network Pathway Diagram
 Iron Uptake And Transport Pathway antibodies  Iron Uptake And Transport Pathway Diagram
 Metal Ion SLC Transporters Pathway antibodies  Metal Ion SLC Transporters Pathway Diagram
 Porphyrin And Chlorophyll Metabolism Pathway antibodies  Porphyrin And Chlorophyll Metabolism Pathway Diagram
 Porphyrin And Chlorophyll Metabolism Pathway antibodies  Porphyrin And Chlorophyll Metabolism Pathway Diagram
 SLC-mediated Transmembrane Transport Pathway antibodies  SLC-mediated Transmembrane Transport Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Transport Of Glucose And Other Sugars, Bile Salts And Organic Acids, Metal Ions And Amine Compounds Pathway antibodies  Transport Of Glucose And Other Sugars, Bile Salts And Organic Acids, Metal Ions And Amine Compounds Pathway Diagram
Diseases associated with CP native proteinOrgans/Tissues associated with CP native protein
 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >4328 publications with CP and Brain Diseases
 Disease Models, Animal Antibodies  >1509 publications with CP and Disease Models, Animal
 Inflammation Antibodies  >1400 publications with CP and Inflammation
 Necrosis Antibodies  >781 publications with CP and Necrosis
 Diabetes Mellitus Antibodies  >690 publications with CP and Diabetes Mellitus
 Ischemia Antibodies  >642 publications with CP and Ischemia
 Hypertension Antibodies  >582 publications with CP and Hypertension
 Kidney Diseases Antibodies  >558 publications with CP and Kidney Diseases
 Fibrosis Antibodies  >468 publications with CP and Fibrosis
 Weight Loss Antibodies  >417 publications with CP and Weight Loss
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >8780 publications with CP and Blood
 Brain Antibodies  >3891 publications with CP and Brain
 Muscle Antibodies  >3194 publications with CP and Muscle
 Liver Antibodies  >2148 publications with CP and Liver
 Bone Antibodies  >2122 publications with CP and Bone
 Vascular Antibodies  >1553 publications with CP and Vascular
 Lung Antibodies  >1547 publications with CP and Lung
 Kidney Antibodies  >1177 publications with CP and Kidney
 Intestine Antibodies  >1149 publications with CP and Intestine
 Nerve Antibodies  >1088 publications with CP and Nerve
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