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C1QB native protein :: Complement C1q Native Protein

Scan QR to view Datasheet Catalog #    MBS537906 C1QB native protein
Unit / Price
1 mg  /  $780 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Complement C1q (C1QB), Native Protein

 Also Known As   

Complement C1q protein

 Product Synonym Names    C1q protein
 Product Gene Name   

C1QB native protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    120570
 3D Structure    ModBase 3D Structure for P02746
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 Host    Human
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 Purity/Purification    > 96% pure
 Form/Format    Lyophilized from 0.01M Na2EDTA, pH 7.5, with 0.3M NaCl.
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 Source Note    Human plasma
 Protein Type    Native
 Biological Significance    Complement C1q is a 400kDa protein formed from 18 peptide chains in 3 subunits of 6. Each 6 peptide subunit consists of a Y-shaped pair of triple peptide helices joined at the stem and ending in a globular non-helical head. The C1q complex is potentially multivalent for attachment to the complement fixation sites of immunoglobulin.The appropriate peptide sequence of the complement fixing site might become exposed following complexing of the immunoglobulin, or the sites might always be available, but might require multiple attachment by C1q with critical geometry in order to achieve the necessary avidity.
 Contaminants    None detected by SDS PAGE analysis
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 Preparation and Storage    Store at 4 degree C.
 Other Notes    Small volumes of C1QB native protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for C1QB native protein

   Purified Complement C1q protein isolated from human plasma
 Product Categories/Family for C1QB native protein    Immunology; Native Protein; Complements
NCBI/Uniprot data below describe general gene information for C1QB. It may not necessarily be applicable to this product.
 NCBI GI #    87298828
 NCBI GeneID    713
 NCBI Accession #    NP_000482.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_000491.3 [Other Products]
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 UniProt Primary Accession #    P02746 [Other Products]
 UniProt Secondary Accession #    Q5T959; Q96H17 [Other Products]
 UniProt Related Accession #    P02746 [Other Products]
 Molecular Weight    410 kDa [Similar Products]
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 NCBI Official Full Name    complement C1q subcomponent subunit B
 NCBI Official Synonym Full Names    complement component 1, q subcomponent, B chain
 NCBI Official Symbol    C1QB [Similar Products]
 NCBI Protein Information    complement C1q subcomponent subunit B
 UniProt Protein Name    Complement C1q subcomponent subunit B
 Protein Family    Complement C1q-like protein
 UniProt Gene Name    C1QB [Similar Products]
 UniProt Entry Name    C1QB_HUMAN
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 NCBI Summary for C1QB    This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the B-chain polypeptide of human complement subcomponent C1q [provided by RefSeq, Jul 2008]
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 UniProt Comments for C1QB    C1QB: C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. Defects in C1QB are a cause of complement component C1q deficiency (C1QD). A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1p36.12

Cellular Component: collagen; extracellular region; complement component C1 complex

Molecular Function: protein binding; protein homodimerization activity

Biological Process: innate immune response; complement activation, classical pathway; inner ear development; complement activation

Disease: C1q Deficiency
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 Research Articles on C1QB    1. PepO facilitates C1q-mediated bacterial adherence, whereas its localized release consumes complement as a result of its activation following binding of C1q, thus representing an additional mechanism of human complement escape by this versatile pathogen.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with C1QB native proteinPathways associated with C1QB native protein
 Reference Product  PubMed Publications
 C1QA native protein  >27 publications with C1QB and C1QA
 C1QC native protein  >21 publications with C1QB and C1QC
 C1R native protein  >6 publications with C1QB and C1R
 C1S native protein  >5 publications with C1QB and C1S
 SERPING1 native protein  >2 publications with C1QB and SERPING1
 C4B native protein  >2 publications with C1QB and C4B
 CRP native protein  >2 publications with C1QB and CRP
 CSTB native protein  >1 publications with C1QB and CSTB
 Products by Pathway  Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Classical Antibody-mediated Complement Activation Pathway antibodies  Classical Antibody-mediated Complement Activation Pathway Diagram
 Complement Activation, Classical Pathway antibodies  Complement Activation, Classical Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement Cascade Pathway antibodies  Complement Cascade Pathway Diagram
 Creation Of C4 And C2 Activators Pathway antibodies  Creation Of C4 And C2 Activators Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
Diseases associated with C1QB native proteinOrgans/Tissues associated with C1QB native protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >21 publications with C1QB and Nervous System Diseases
 Inflammation Antibodies  >14 publications with C1QB and Inflammation
 Disease Models, Animal Antibodies  >7 publications with C1QB and Disease Models, Animal
 Necrosis Antibodies  >6 publications with C1QB and Necrosis
 Kidney Diseases Antibodies  >4 publications with C1QB and Kidney Diseases
 Liver Diseases Antibodies  >3 publications with C1QB and Liver Diseases
 Cardiovascular Diseases Antibodies  >3 publications with C1QB and Cardiovascular Diseases
 Memory Disorders Antibodies  >2 publications with C1QB and Memory Disorders
 Poisoning Antibodies  >1 publications with C1QB and Poisoning
 Learning Disorders Antibodies  >1 publications with C1QB and Learning Disorders
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >25 publications with C1QB and Brain
 Bone Antibodies  >7 publications with C1QB and Bone
 Connective Tissue Antibodies  >5 publications with C1QB and Connective Tissue
 Eye Antibodies  >5 publications with C1QB and Eye
 Vascular Antibodies  >4 publications with C1QB and Vascular
 Mouth Antibodies  >3 publications with C1QB and Mouth
 Lung Antibodies  >3 publications with C1QB and Lung
 Liver Antibodies  >3 publications with C1QB and Liver
 Kidney Antibodies  >3 publications with C1QB and Kidney
 Spleen Antibodies  >2 publications with C1QB and Spleen
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