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C3 native protein :: Complement C3 Native Protein

Scan QR to view Datasheet Catalog #    MBS355514 (SPECIAL PRICING: 1 unit is in stock at 40% OFF web price.
Please contact customer service for more information)
C3 native protein
Unit / Price
0.1 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $445 +1 FREE 8GB USB
 
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 Product Name   

Complement C3, Native Protein

★Popular Item★
 Also Known As   

Complement C3 Protein (Active)

 Product Synonym Names    Complement C3, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1, C3, CPAMD1
 Product Gene Name   

C3 native protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS355514 COA    COA PDF
 MBS355514 Technical Datasheet    Technical Datasheet PDF
 Chromosome Location    Chromosome: 19; NC_000019.9 (6677846..6720662, complement). Location: 19p13.3-p13.2
 OMIM    120700
 3D Structure    ModBase 3D Structure for P01024
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 Host    Human Plasma
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 Purity/Purification    >90% by SDS-PAGE
 Form/Format    Liquid
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 Buffer    Each vial contains 10mM PBS (pH7.4)
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 Preparation and Storage    Ship at 4C. Upon receipt, aliquot and store at -20C or -80C for long term.

Avoid repeated freeze and thaw cycles.
 Other Notes    Small volumes of C3 native protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for C3 native protein

   Purified human Complement C3 protein

Background: Complement component 3, often simply called C3, is a member of the complement system. The complement system is an important mediator of natural and acquired immunity. It consists of approximately 30 proteins that can exhibit catalytic activity, function as regulators, or act as cellular surface receptors. These components normally circulate in inactive forms and are activated by the classical, alternative, or lectin pathways. Complement component 3 plays a central role in all 3 activation pathways. People with C3 deficiency are susceptible to bacterial infection. Clinically, the Level of C3 in the blood may be measured to support or refute a particular medical diagnosis. For example, low C3 levels are associated with some types of kidney disease such as post-infectious glomerulonephritis and shunt nephritis.
 Applications Tested/Suitable for C3 native protein   

ELISA (EIA)

 Application Notes for C3 native protein    Other applications have not been tested. The optimal dilutions should be determined by end user.
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NCBI/Uniprot data below describe general gene information for C3. It may not necessarily be applicable to this product.
 NCBI GI #    115298678
 NCBI GeneID    718
 NCBI Accession #    NP_000055.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000064.2 [Other Products]
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 UniProt Primary Accession #    P01024 [Other Products]
 UniProt Secondary Accession #    A7E236 [Other Products]
 UniProt Related Accession #    P01024 [Other Products]
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 NCBI Official Full Name    complement C3
 NCBI Official Synonym Full Names    complement component 3
 NCBI Official Symbol    C3 [Similar Products]
 NCBI Official Synonym Symbols   
ASP; C3a; C3b; AHUS5; ARMD9; CPAMD1
[Similar Products]
 NCBI Protein Information    complement C3; prepro-C3; C3a anaphylatoxin; complement component C3; complement component C3a; complement component C3b; acylation-stimulating protein cleavage product; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1
 UniProt Protein Name    Complement C3
 UniProt Synonym Protein Names   
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1Cleaved into the following 11 chains:Complement C3 beta chainComplement C3 alpha chainC3a anaphylatoxinAcylation stimulating protein; ASP; Alternative name(s):; C3adesArg
 Protein Family    Complement C3
 UniProt Gene Name    C3 [Similar Products]
 UniProt Synonym Gene Names    CPAMD1; ASP [Similar Products]
 UniProt Entry Name    CO3_HUMAN
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 NCBI Summary for C3    Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. People with C3 deficiency are susceptible to bacterial infection. [provided by RefSeq, Feb 2009]
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 UniProt Comments for C3    Function: C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. Ref.5 Ref.11 Ref.14 Ref.15 Ref.16 Ref.22 Ref.25 Ref.29Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. Ref.5 Ref.11 Ref.14 Ref.15 Ref.16 Ref.22 Ref.25 Ref.29Acylation stimulating protein (ASP): adipogenic hormone that stimulates triglyceride (TG) synthesis and glucose transport in adipocytes, regulating fat storage and playing a role in postprandial TG clearance. Appears to stimulate TG synthesis via activation of the PLC, MAPK and AKT signaling pathways. Ligand for C5AR2. Promotes the phosphorylation, ARRB2-mediated internalization and recycling of C5AR2. Ref.5 Ref.11 Ref.14 Ref.15 Ref.16 Ref.22 Ref.25 Ref.29

Subunit structure: C3 precursor is first processed by the removal of 4 Arg residues, forming two chains, beta and alpha, linked by a disulfide bond. C3 convertase activates C3 by cleaving the alpha chain, releasing C3a anaphylatoxin and generating C3b (beta chain + alpha' chain). C3dg interacts with CR2 (via the N-terminal Sushi domains 1 and 2). During pregnancy, C3dg exists as a complex (probably a 2:2:2 heterohexamer) with AGT and the proform of PRG2. Interacts with VSIG4. C3b interacts with herpes simplex virus 1 (HHV-1) and herpes simplex virus 2 (HHV-2) envelope glycoprotein C; this interaction inhibits the activation of the complement system. Interacts with S.aureus immunoglobulin-binding protein sbi, this prevents interaction between C3dg and CR2. Interacts with S.aureus fib. Interacts (both C3a and ASP) with C5AR2; the interaction occurs with higher affinity for ASP, enhancing the phosphorylation and activation of C5AR2, recruitment of ARRB2 to the cell surface and endocytosis of GRP77. Ref.7 Ref.10 Ref.17 Ref.18 Ref.30 Ref.31 Ref.43 Ref.44

Subcellular location: Secreted.

Tissue specificity: Plasma. The acylation stimulating protein (ASP) is expressed in adiopocytes and released into the plasma during both the fasting and postprandial periods. Ref.15 Ref.22

Post-translational modification: C3b is rapidly split in two positions by factor I and a cofactor to form iC3b (inactivated C3b) and C3f which is released. Then iC3b is slowly cleaved (possibly by factor I) to form C3c (beta chain + alpha' chain fragment 1 + alpha' chain fragment 2), C3dg and C3f. Other proteases produce other fragments such as C3d or C3g. C3a is further processed by carboxypeptidases to release the C-terminal arginine residue generating the acylation stimulating protein (ASP). Levels of ASP are increased in adipocytes in the postprandial period and by insulin and dietary chylomicrons.Phosphorylation sites are present in the extracellular medium.

Polymorphism: There are two alleles: C3S (C3 slow), the most common allele in all races and C3F (C3 fast), relatively frequent in Caucasians, less common in Black Americans, extremely rare in Orientals.

Involvement in disease: Complement component 3 deficiency (C3D) [MIM:613779]: A rare defect of the complement classical pathway. Patients develop recurrent, severe, pyogenic infections because of ineffective opsonization of pathogens. Some patients may also develop autoimmune disorders, such as arthralgia and vasculitic rashes, lupus-like syndrome and membranoproliferative glomerulonephritis.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.32 Ref.35 Ref.36 Ref.37 Ref.48 Ref.49Age-related macular degeneration 9 (ARMD9) [MIM:611378]: A form of age-related macular degeneration, a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane.Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Ref.32 Ref.50Hemolytic uremic syndrome atypical 5 (AHUS5) [MIM:612925]: An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease.Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Other genes may play a role in modifying the phenotype. Ref.32 Ref.51 Ref.52Increased levels of C3 and its cleavage product ASP, are associated with obesity, diabetes and coronary heart disease. Short-term endurance training reduces baseline ASP levels and subsequently fat storage. Ref.32

Sequence similarities: Contains 1 anaphylatoxin-like domain.Contains 1 NTR domain.

Caution: According to Ref.44, the interaction surface between C3 and CR2 reported in Ref.36 is artifactual and can be ascribed to the presence of zinc acetate in the buffer.
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 Research Articles on C3    1. Our preliminary observations suggest that TNF-alpha may induce EMT in RTECs through inducing C3 expression
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with C3 native proteinPathways associated with C3 native protein
 Reference Product  PubMed Publications
 CR1 native protein  >416 publications with C3 and CR1
 CR2 native protein  >287 publications with C3 and CR2
 CFH native protein  >188 publications with C3 and CFH
 CD46 native protein  >186 publications with C3 and CD46
 ITGAM native protein  >70 publications with C3 and ITGAM
 CFI native protein  >70 publications with C3 and CFI
 ITGAX native protein  >18 publications with C3 and ITGAX
 C3AR1 native protein  >3 publications with C3 and C3AR1
 CFD native protein  >3 publications with C3 and CFD
 Products by Pathway  Pathway Diagram
 Activation Of C3 And C5 Pathway antibodies  Activation Of C3 And C5 Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Alternative Complement Activation Pathway antibodies  Alternative Complement Activation Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Complement Activation, Classical Pathway antibodies  Complement Activation, Classical Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
Diseases associated with C3 native proteinOrgans/Tissues associated with C3 native protein
 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >3512 publications with C3 and Kidney Diseases
 Neoplasms Antibodies  >2638 publications with C3 and Neoplasms
 Nervous System Diseases Antibodies  >2621 publications with C3 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >2273 publications with C3 and Cardiovascular Diseases
 Inflammation Antibodies  >1793 publications with C3 and Inflammation
 Proteinuria Antibodies  >1217 publications with C3 and Proteinuria
 Lung Diseases Antibodies  >986 publications with C3 and Lung Diseases
 Pain Antibodies  >904 publications with C3 and Pain
 Liver Diseases Antibodies  >894 publications with C3 and Liver Diseases
 Necrosis Antibodies  >885 publications with C3 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >11436 publications with C3 and Blood
 Kidney Antibodies  >3354 publications with C3 and Kidney
 Bone Antibodies  >2703 publications with C3 and Bone
 Skin Antibodies  >2200 publications with C3 and Skin
 Brain Antibodies  >1974 publications with C3 and Brain
 Liver Antibodies  >1720 publications with C3 and Liver
 Muscle Antibodies  >1605 publications with C3 and Muscle
 Spinal Cord Antibodies  >1451 publications with C3 and Spinal Cord
 Nerve Antibodies  >1273 publications with C3 and Nerve
 Lung Antibodies  >1053 publications with C3 and Lung
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