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C3 native protein :: Complement C3c Native Protein

Scan QR to view Datasheet Catalog #    MBS537037 C3 native protein
Unit / Price
1 mg  /  $535 +1 FREE 8GB USB
10 mg  /  $2,240 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Complement C3c, Native Protein

★Popular Item★
 Also Known As   

Complement C3c protein

 Product Synonym Names    C3c protein
 Product Gene Name   

C3 native protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    120700
 3D Structure    ModBase 3D Structure for P01024
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 Host    Human
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 Purity/Purification    > 99% pure
 Form/Format    Supplied frozen in NaH2PO4, pH 7.2, with 150mM NaCl.
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 Source Note    Human plasma
 Protein Type    Native
 Biological Significance    Complement component 3, often simply called C3, is a protein of the immune system. It plays a central role in the complement system and contributes to innate immunity. In humans it is encoded on chromosome 19 by a gene called C3. C3 plays a central role in the activation of the complement system.
 Dry Ice Shipment    Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
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 Preparation and Storage    Aliquot and store at -20 degree C. Avoid repeated freeze/thaw cycles
 Other Notes    Small volumes of C3 native protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for C3 native protein

   Purified Complement C3c protein isolated from human plasma
 Product Categories/Family for C3 native protein    Immunology; Native Protein; Complements
NCBI/Uniprot data below describe general gene information for C3. It may not necessarily be applicable to this product.
 NCBI GI #    115298678
 NCBI GeneID    718
 NCBI Accession #    NP_000055.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000064.2 [Other Products]
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 UniProt Primary Accession #    P01024 [Other Products]
 UniProt Secondary Accession #    A7E236 [Other Products]
 UniProt Related Accession #    P01024 [Other Products]
 Molecular Weight    137 kDa [Similar Products]
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 NCBI Official Full Name    complement C3
 NCBI Official Synonym Full Names    complement component 3
 NCBI Official Symbol    C3 [Similar Products]
 NCBI Official Synonym Symbols   
ASP; C3a; C3b; AHUS5; ARMD9; CPAMD1; HEL-S-62p
[Similar Products]
 NCBI Protein Information    complement C3
 UniProt Protein Name    Complement C3
 UniProt Synonym Protein Names   
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1
 Protein Family    Complement C3
 UniProt Gene Name    C3 [Similar Products]
 UniProt Synonym Gene Names    CPAMD1; C3bc; ASP [Similar Products]
 UniProt Entry Name    CO3_HUMAN
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 NCBI Summary for C3    Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. A peptide (C3a) derived from the encoded protein has antimicrobial activity, so people with C3 deficiency are susceptible to bacterial infection. [provided by RefSeq, Nov 2014]
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 UniProt Comments for C3    C3: C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. Defects in C3 are the cause of complement component 3 deficiency (C3D). A rare defect of the complement classical pathway. Patients develop recurrent, severe, pyogenic infections because of ineffective opsonization of pathogens. Some patients may also develop autoimmune disorders, such as arthralgia and vasculitic rashes, lupus-like syndrome and membranoproliferative glomerulonephritis. Genetic variation in C3 is associated with susceptibility to age-related macular degeneration type 9 (ARMD9). ARMD is a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin- containing structure known as Bruch membrane. Defects in C3 are a cause of susceptibility to hemolytic uremic syndrome atypical type 5 (AHUS5). An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. Susceptibility to the development of atypical hemolytic uremic syndrome can be conferred by mutations in various components of or regulatory factors in the complement cascade system. Other genes may play a role in modifying the phenotype. Increased levels of C3 and its cleavage product ASP, are associated with obesity, diabetes and coronary heart disease. Short-term endurance training reduces baseline ASP levels and subsequently fat storage.

Protein type: Inhibitor; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 19p13.3-p13.2

Cellular Component: extracellular space; extracellular region; plasma membrane

Molecular Function: protein binding; endopeptidase inhibitor activity; C5L2 anaphylatoxin chemotactic receptor binding; receptor binding

Biological Process: G-protein coupled receptor protein signaling pathway; regulation of immune response; positive regulation of angiogenesis; positive regulation of activation of membrane attack complex; positive regulation of G-protein coupled receptor protein signaling pathway; positive regulation of type IIa hypersensitivity; complement activation, alternative pathway; regulation of complement activation; innate immune response; immune response; positive regulation of protein amino acid phosphorylation; inflammatory response; signal transduction; fatty acid metabolic process; complement activation, classical pathway; complement activation

Disease: Complement Component 3 Deficiency, Autosomal Recessive; Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 5; Macular Degeneration, Age-related, 9
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 Research Articles on C3    1. The mutations in the regulators CFH, CFI and MCP involve loss-of-function, whereas those for C3 involve gain-of-function.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with C3 native proteinPathways associated with C3 native protein
 Reference Product  PubMed Publications
 CR1 native protein  >432 publications with C3 and CR1
 CR2 native protein  >297 publications with C3 and CR2
 CFH native protein  >221 publications with C3 and CFH
 CD46 native protein  >204 publications with C3 and CD46
 CFI native protein  >79 publications with C3 and CFI
 ITGAM native protein  >73 publications with C3 and ITGAM
 CFHR1 native protein  >50 publications with C3 and CFHR1
 CFP native protein  >10 publications with C3 and CFP
 CFD native protein  >4 publications with C3 and CFD
 VSIG4 native protein  >1 publications with C3 and VSIG4
 Products by Pathway  Pathway Diagram
 Activation Of C3 And C5 Pathway antibodies  Activation Of C3 And C5 Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Alternative Complement Activation Pathway antibodies  Alternative Complement Activation Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Complement Activation, Classical Pathway antibodies  Complement Activation, Classical Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
Diseases associated with C3 native proteinOrgans/Tissues associated with C3 native protein
 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >3750 publications with C3 and Kidney Diseases
 Cardiovascular Diseases Antibodies  >2467 publications with C3 and Cardiovascular Diseases
 Inflammation Antibodies  >2031 publications with C3 and Inflammation
 Proteinuria Antibodies  >1318 publications with C3 and Proteinuria
 Lung Diseases Antibodies  >1025 publications with C3 and Lung Diseases
 Brain Diseases Antibodies  >978 publications with C3 and Brain Diseases
 Necrosis Antibodies  >953 publications with C3 and Necrosis
 Liver Diseases Antibodies  >949 publications with C3 and Liver Diseases
 Hemorrhage Antibodies  >791 publications with C3 and Hemorrhage
 Anemia Antibodies  >766 publications with C3 and Anemia
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >12102 publications with C3 and Blood
 Kidney Antibodies  >3601 publications with C3 and Kidney
 Bone Antibodies  >3075 publications with C3 and Bone
 Skin Antibodies  >2303 publications with C3 and Skin
 Brain Antibodies  >2172 publications with C3 and Brain
 Liver Antibodies  >1848 publications with C3 and Liver
 Muscle Antibodies  >1738 publications with C3 and Muscle
 Spinal Cord Antibodies  >1635 publications with C3 and Spinal Cord
 Nerve Antibodies  >1384 publications with C3 and Nerve
 Lung Antibodies  >1113 publications with C3 and Lung
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